PDB: 7770 件ウェブページステータス検索Chemie searchBIRD

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3E5V	Crystal Structure Analysis of eqFP611 Double Mutant T122R, N143S 分子名称: Red fluorescent protein eqFP611 著者 Nar, H, Nienhaus, K, Nienhaus, U, Wiedenmann, J. 登録日 2008-08-14 公開日 2008-09-23 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Trans-cis isomerization is responsible for the red-shifted fluorescence in variants of the red fluorescent protein eqFP611. J.Am.Chem.Soc., 130, 2008
3IW5	Human p38 MAP Kinase in Complex with an Indole Derivative 分子名称: Mitogen-activated protein kinase 14, N-[2-(3-{[2-(2,3-dihydro-1,4-benzodioxin-6-ylamino)-2-oxoethyl]sulfanyl}-1H-indol-1-yl)ethyl]-3-(trifluoromethyl)benzamide, octyl beta-D-glucopyranoside 著者 Gruetter, C, Simard, J.R, Rauh, D. 登録日 2009-09-02 公開日 2009-11-17 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 High-Throughput Screening To Identify Inhibitors Which Stabilize Inactive Kinase Conformations in p38alpha J.Am.Chem.Soc., 131, 2009
3EHV	X-ray structure of human ubiquitin Zn(II) adduct 分子名称: Ubiquitin, ZINC ION 著者 Falini, G, Fermani, S, Tosi, G. 登録日 2008-09-15 公開日 2009-03-17 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.81 Å) 主引用文献 Structural probing of Zn(II), Cd(II) and Hg(II) binding to human ubiquitin. Chem.Commun.(Camb.), 45, 2008
2RQ1	Solution structure of the 4.1R FERM alpha lobe domain 分子名称: Protein 4.1 著者 Kusunoki, H, Kohno, T. 登録日 2009-01-09 公開日 2009-04-14 最終更新日 2024-05-29 実験手法 SOLUTION NMR 主引用文献 Solution structure and glycophorin C binding studies of the protein 4.1R FERM alpha-lobe domain Proteins, 76, 2009
2R93	Elongation complex of RNA polymerase II with a hepatitis delta virus-derived RNA stem loop 分子名称: DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB11, DNA-directed RNA polymerase II subunit RPB2, ... 著者 Lehmann, E, Brueckner, F, Cramer, P. 登録日 2007-09-12 公開日 2007-11-27 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (4 Å) 主引用文献 Molecular basis of RNA-dependent RNA polymerase II activity. Nature, 450, 2007
3ENS	Crystal structure of human FXA in complex with methyl (2Z)-3-[(3-chloro-1H-indol-7-yl)amino]-2-cyano-3-{[(3S)-2-oxo-1-(2-oxo-2-pyrrolidin-1-ylethyl)azepan-3-yl]amino}acrylate 分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ACETATE ION, Activated factor Xa heavy chain, ... 著者 Klei, H.E. 登録日 2008-09-25 公開日 2008-12-30 最終更新日 2017-10-25 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Design, Structure-Activity Relationships, X-ray Crystal Structure, and Energetic Contributions of a Critical P1 Pharmacophore: 3-Chloroindole-7-yl-Based Factor Xa Inhibitors. J.Med.Chem., 51, 2008
3IK9	Human GST A1-1-GIMF with GSDHN 分子名称: (S)-2-amino-5-((R)-1-(carboxymethylamino)-3-((3S,4R)-1,4-dihydroxynonan-3-ylthio)-1-oxopropan-2-ylamino)-5-oxopentanoic acid, Glutathione S-transferase A1 著者 Balogh, L.M, Le Trong, I, Atkins, W.M, Stenkamp, R.E. 登録日 2009-08-05 公開日 2010-06-23 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Substrate specificity combined with stereopromiscuity in glutathione transferase A4-4-dependent metabolism of 4-hydroxynonenal. Biochemistry, 49, 2010
2RD6	PARP complexed with A861695 分子名称: (2R)-2-(7-carbamoyl-1H-benzimidazol-2-yl)-2-methylpyrrolidinium, Poly [ADP-ribose] polymerase 1 著者 Park, C.H. 登録日 2007-09-21 公開日 2008-09-23 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 PARP complexed with A861695 To be Published
3IM4	Crystal structure of cAMP-dependent Protein Kinase A Regulatory Subunit I alpha in complex with dual-specific A-Kinase Anchoring Protein 2 分子名称: Dual specificity A kinase-anchoring protein 2, ZINC ION, cAMP-dependent protein kinase type I-alpha regulatory subunit 著者 Sarma, G.N, Kinderman, F.S, Kim, C, von Daake, S, Taylor, S.S. 登録日 2009-08-09 公開日 2010-02-02 最終更新日 2022-12-21 実験手法 X-RAY DIFFRACTION (2.285 Å) 主引用文献 Structure of D-AKAP2:PKA RI Complex: Insights into AKAP Specificity and Selectivity Structure, 18, 2010
2REA	Crystal structures of C2ALPHA-PI3 kinase PX-domain domain indicate conformational change associated with ligand binding. 分子名称: Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide 著者 Parkinson, G.N, Vines, D, Driscoll, P.C, Djordjevic, S. 登録日 2007-09-26 公開日 2007-11-27 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Crystal structures of PI3K-C2alpha PX domain indicate conformational change associated with ligand binding Bmc Struct.Biol., 8, 2008
3IMT	Transthyretin in complex with (E)-4-(4-aminostyryl)-2,6-dibromophenol 分子名称: 4-[(E)-2-(4-aminophenyl)ethenyl]-2,6-dibromophenol, Transthyretin 著者 Connelly, S, Wilson, I. 登録日 2009-08-11 公開日 2010-01-12 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 A substructure combination strategy to create potent and selective transthyretin kinetic stabilizers that prevent amyloidogenesis and cytotoxicity. J.Am.Chem.Soc., 132, 2010
3EKZ	Structural Characterization of tetrameric Mycobacterium tuberculosis fructose 1,6-bisphosphate aldolase - substrate binding and catalysis mechanism of a class IIa bacterial aldolase 分子名称: 1,3-DIHYDROXYACETONEPHOSPHATE, Fructose-bisphosphate aldolase, SN-GLYCEROL-3-PHOSPHATE, ... 著者 Pegan, S, Rukseree, K, Franzblau, S.G, Mesecar, A.D. 登録日 2008-09-19 公開日 2009-02-10 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.07 Å) 主引用文献 Structural basis for catalysis of a tetrameric class IIa fructose 1,6-bisphosphate aldolase from Mycobacterium tuberculosis J.Mol.Biol., 386, 2009
2RG8	Crystal Structure of Programmed for Cell Death 4 Middle MA3 domain 分子名称: CHLORIDE ION, Programmed cell death protein 4, SODIUM ION 著者 Garces, R, Suzuki, C, Wagner, G. 登録日 2007-10-03 公開日 2008-03-04 最終更新日 2017-10-25 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 PDCD4 inhibits translation initiation by binding to eIF4A using both its MA3 domains. Proc.Natl.Acad.Sci.Usa, 105, 2008
3EP4	Human AdoMetDC E256Q mutant with no putrescine bound 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, PYRUVIC ACID, S-adenosylmethionine decarboxylase alpha chain, ... 著者 Bale, S, Lopez, M.M, Makhatadze, G.I, Fang, Q, Pegg, A.E, Ealick, S.E. 登録日 2008-09-29 公開日 2008-12-23 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.89 Å) 主引用文献 Structural Basis for Putrescine Activation of Human S-Adenosylmethionine Decarboxylase. Biochemistry, 47, 2008
3IC0	Crystal Structure of liganded hemoglobin in complex with a potent antisickling agent, INN-298 分子名称: 2-[(2-methoxy-5-methylphenoxy)methyl]pyridine, Hemoglobin subunit alpha, Hemoglobin subunit beta, ... 著者 Safo, M.K, Musayev, F.N, Gandhi, A.K, Jorge, P. 登録日 2009-07-17 公開日 2009-07-28 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structural and in Vitro Chracterization of Pridyl Derivatives of Benzaldehydes: Highly Potent Antisickling Agents To be Published
3ITZ	Crystal Structure of p38a Mitogen-Activated Protein Kinase in Complex with a Pyrazolopyridazine Inhibitor 分子名称: 4-chloro-N-cyclopropyl-3-{[1-(2,6-difluorophenyl)-1H-pyrazolo[3,4-d]pyridazin-4-yl]amino}benzamide, Mitogen-activated protein kinase 14 著者 Mohr, C, Jordan, S. 登録日 2009-08-28 公開日 2010-03-02 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Part 2: Structure-activity relationship (SAR) investigations of fused pyrazoles as potent, selective and orally available inhibitors of p38alpha mitogen-activated protein kinase. Bioorg.Med.Chem.Lett., 20, 2010
2R64	Crystal structure of a 3-aminoindazole compound with CDK2 分子名称: Cell division protein kinase 2, N-[5-(1,1-DIOXIDOISOTHIAZOLIDIN-2-YL)-1H-INDAZOL-3-YL]-2-(4-PIPERIDIN-1-YLPHENYL)ACETAMIDE 著者 Lee, J, Choi, H, Kim, K.H, Jeong, S, Park, J.W, Baek, C.S, Lee, S.H. 登録日 2007-09-05 公開日 2008-09-09 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Synthesis and biological evaluation of 3,5-diaminoindazoles as cyclin-dependent kinase inhibitors. Bioorg.Med.Chem.Lett., 18, 2008
3E5W	Crystal Structure Analysis of FP611 分子名称: Red fluorescent protein eqFP611 著者 Nienhaus, K, Nar, H, Heilker, R, Wiedenmann, J, Nienhaus, G.U. 登録日 2008-08-14 公開日 2008-09-23 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.71 Å) 主引用文献 Trans-cis isomerization is responsible for the red-shifted fluorescence in variants of the red fluorescent protein eqFP611. J.Am.Chem.Soc., 130, 2008
3I7L	Crystal Structure of DDB1 in Complex with the H-Box Motif of DDB2 分子名称: DNA damage-binding protein 1, DNA damage-binding protein 2 著者 Li, T, Robert, E.I, Breugel, P.C.V, Strubin, M, Zheng, N. 登録日 2009-07-08 公開日 2009-12-08 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 A promiscuous alpha-helical motif anchors viral hijackers and substrate receptors to the CUL4-DDB1 ubiquitin ligase machinery. Nat.Struct.Mol.Biol., 17, 2010
3E5S	Crystal structure of Staphylococcal nuclease variant Delta+PHS L103K at cryogenic temperature 分子名称: CALCIUM ION, THYMIDINE-3',5'-DIPHOSPHATE, Thermonuclease 著者 Khangulov, V.S, Schlessman, J.L, Garcia-Moreno, E.B. 登録日 2008-08-14 公開日 2008-11-04 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Crystal structure of Staphylococcal nuclease variant Delta+PHS L103K at cryogenic temperature To be Published
3IFW	Crystal structure of the S18Y variant of ubiquitin carboxy terminal hydrolase L1 bound to ubiquitin vinylmethylester. 分子名称: METHYL 4-AMINOBUTANOATE, Ubiquitin, Ubiquitin carboxyl-terminal hydrolase isozyme L1 著者 Das, C, Boudreaux, D, Maiti, T. 登録日 2009-07-26 公開日 2010-06-16 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Ubiquitin vinyl methyl ester binding orients the misaligned active site of the ubiquitin hydrolase UCHL1 into productive conformation. Proc.Natl.Acad.Sci.USA, 107, 2010
3IA3	A cis-proline in alpha-hemoglobin stabilizing Protein directs the structural reorganization of alpha-hemoglobin 分子名称: Alpha-hemoglobin-stabilizing protein, Hemoglobin subunit alpha, PROTOPORPHYRIN IX CONTAINING FE 著者 Feng, L, Jeffrey, P.D, Shi, Y. 登録日 2009-07-13 公開日 2009-07-28 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 A cis-proline in alpha-hemoglobin stabilizing protein directs the structural reorganization of alpha-hemoglobin. J.Biol.Chem., 284, 2009
3EDZ	Crystal structure of catalytic domain of TACE with hydroxamate inhibitor 分子名称: ADAM 17, CITRIC ACID, N-{(2R)-2-[2-(hydroxyamino)-2-oxoethyl]-4-methylpentanoyl}-3-methyl-L-valyl-N-(2-aminoethyl)-L-alaninamide, ... 著者 Mazzola, R.D, Zhu, Z, Sinning, L, McKittrick, B, Lavey, B, Spitler, J, Kozlowski, J, Neng-Yang, S, Zhou, G, Guo, Z, Orth, P, Madison, V, Sun, J, Lundell, D, Niu, X. 登録日 2008-09-03 公開日 2008-09-23 最終更新日 2021-10-20 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Discovery of novel hydroxamates as highly potent tumor necrosis factor-alpha converting enzyme inhibitors. Part II: optimization of the S3' pocket. Bioorg.Med.Chem.Lett., 18, 2008
3EFG	Structure of SlyX protein from Xanthomonas campestris pv. campestris str. ATCC 33913 分子名称: 1,2-ETHANEDIOL, Protein slyX homolog 著者 Cuff, M.E, Xu, X, Cui, H, Savchenko, A, Edwards, A, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) 登録日 2008-09-08 公開日 2008-12-09 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structure of SlyX protein from Xanthomonas campestris pv. campestris str. ATCC 33913 TO BE PUBLISHED
3II6	Structure of human Xrcc4 in complex with the tandem BRCT domains of DNA LigaseIV. 分子名称: CHLORIDE ION, DNA ligase 4, DNA repair protein XRCC4 著者 Meesala, S, Junop, M. 登録日 2009-07-31 公開日 2009-08-11 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structural and functional interaction between the human DNA repair proteins DNA ligase IV and XRCC4 MOL.CELL.BIOL., 11, 2009

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