PDB: 5554 件ウェブページステータス検索Chemie searchBIRD

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1SEU	Human DNA Topoisomerase I (70 Kda) In Complex With The Indolocarbazole SA315F and Covalent Complex With A 22 Base Pair DNA Duplex 分子名称: 2,10-DIHYDROXY-12-(BETA-D-GLUCOPYRANOSYL)-6,7,12,13-TETRAHYDROINDOLO[2,3-A]PYRROLO[3,4-C]CARBAZOLE-5,7-DIONE, 5'-D(*(TGP)P*GP*AP*AP*AP*AP*AP*TP*TP*TP*TP*T)-3', 5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*TP*T)-3', ... 著者 Staker, B.L, Feese, M.D, Cushman, M, Pommier, Y, Zembower, D, Stewart, L, Burgin, A.B. 登録日 2004-02-18 公開日 2005-04-19 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Structures of three classes of anticancer agents bound to the human topoisomerase I-DNA covalent complex J.Med.Chem., 48, 2005
1R49	Human topoisomerase I (Topo70) double mutant K532R/Y723F 分子名称: 5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*TP*TP*AP*GP*AP*AP*AP*AP*AP*TP*TP*TP*TP*T)-3', 5'-D(P*AP*AP*AP*AP*AP*TP*TP*TP*TP*TP*CP*TP*AP*AP*GP*TP*CP*TP*TP*TP*TP*T)-3', DNA topoisomerase I 著者 Interthal, H, Quigley, P.M, Hol, W.G, Champoux, J.J. 登録日 2003-10-03 公開日 2003-12-16 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (3.13 Å) 主引用文献 The role of lysine 532 in the catalytic mechanism of human topoisomerase I. J.Biol.Chem., 279, 2004
1UFG	Solution structure of immunoglobulin like domain of mouse nuclear lamin 分子名称: Lamin A 著者 Kobayashi, N, Kigawa, T, Koshiba, S, Inoue, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2003-05-29 公開日 2004-06-22 最終更新日 2023-12-27 実験手法 SOLUTION NMR 主引用文献 Solution structure of immunoglobulin like domain of mouse nuclear lamin To be Published
1T5A	Human Pyruvate Kinase M2 分子名称: 1,6-di-O-phosphono-beta-D-fructofuranose, GLYCEROL, MAGNESIUM ION, ... 著者 Dombrauckas, J.D, Santarsiero, B.D, Mesecar, A.D. 登録日 2004-05-03 公開日 2005-07-12 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Structural basis for tumor pyruvate kinase M2 allosteric regulation and catalysis. Biochemistry, 44, 2005
1SC7	Human DNA Topoisomerase I (70 Kda) In Complex With The Indenoisoquinoline MJ-II-38 and Covalent Complex With A 22 Base Pair DNA Duplex 分子名称: 4-(5,11-DIOXO-5H-INDENO[1,2-C]ISOQUINOLIN-6(11H)-YL)BUTANOATE, 5'-D(*(TGP)P*GP*AP*AP*AP*AP*AP*TP*TP*TP*TP*T)-3', 5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*TP*T)-3', ... 著者 Staker, B.L, Feese, M.D, Cushman, M, Pommier, Y, Zembower, D, Stewart, L, Burgin, A.B. 登録日 2004-02-11 公開日 2005-04-19 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Structures of three classes of anticancer agents bound to the human topoisomerase I-DNA covalent complex J.Med.Chem., 48, 2005
1RRJ	Structural Mechanisms of Camptothecin Resistance by Mutations in Human Topoisomerase I 分子名称: (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE, 2-(1-DIMETHYLAMINOMETHYL-2-HYDROXY-8-HYDROXYMETHYL-9-OXO-9,11-DIHYDRO-INDOLIZINO[1,2-B]QUINOLIN-7-YL)-2-HYDROXY-BUTYRIC ACID, 5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*TP*T*GP*GP*AP*AP*AP*AP*AP*TP*TP*TP*TP*T)-3', ... 著者 Chrencik, J.E, Staker, B.L, Burgin, A.B, Stewart, L, Redinbo, M.R. 登録日 2003-12-08 公開日 2004-07-06 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Mechanisms of camptothecin resistance by human topoisomerase I mutations J.Mol.Biol., 339, 2004
1RKJ	Solution structure of the complex formed by the two N-terminal RNA-binding domains of nucleolin and a pre-rRNA target 分子名称: 5'-R(*GP*GP*AP*UP*GP*CP*CP*UP*CP*CP*CP*GP*AP*GP*UP*GP*CP*AP*UP*CP*C)-3', Nucleolin 著者 Johansson, C, Finger, L.D, Trantirek, L, Mueller, T.D, Kim, S, Laird-Offringa, I.A, Feigon, J. 登録日 2003-11-21 公開日 2004-04-27 最終更新日 2024-05-22 実験手法 SOLUTION NMR 主引用文献 Solution structure of the complex formed by the two N-terminal RNA-binding domains of nucleolin and a pre-rRNA target. J.Mol.Biol., 337, 2004
1U9B	MURINE/HUMAN UBIQUITIN-CONJUGATING ENZYME UBC9 分子名称: UBIQUITIN-CONJUGATING ENZYME E9 著者 Tong, H, Hateboer, G, Perrakis, A, Bernards, R, Sixma, T.K. 登録日 1997-05-20 公開日 1997-07-07 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Crystal structure of murine/human Ubc9 provides insight into the variability of the ubiquitin-conjugating system. J.Biol.Chem., 272, 1997
1U9A	HUMAN UBIQUITIN-CONJUGATING ENZYME UBC9 分子名称: UBIQUITIN-CONJUGATING ENZYME 著者 Tong, H, Hateboer, G, Perrakis, A, Bernards, R, Sixma, T.K. 登録日 1997-02-11 公開日 1997-05-15 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Crystal structure of murine/human Ubc9 provides insight into the variability of the ubiquitin-conjugating system. J.Biol.Chem., 272, 1997
1RR8	Structural Mechanisms of Camptothecin Resistance by Mutations in Human Topoisomerase I 分子名称: (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE, 2-(1-DIMETHYLAMINOMETHYL-2-HYDROXY-8-HYDROXYMETHYL-9-OXO-9,11-DIHYDRO-INDOLIZINO[1,2-B]QUINOLIN-7-YL)-2-HYDROXY-BUTYRIC ACID, 5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*TP*T*GP*GP*AP*AP*AP*AP*AP*TP*TP*TP*TP*T)-3', ... 著者 Chrencik, J.E, Staker, B.L, Burgin, A.B, Stewart, L, Redinbo, M.R. 登録日 2003-12-08 公開日 2004-07-06 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Mechanisms of camptothecin resistance by human topoisomerase I mutations J.Mol.Biol., 339, 2004
1T8I	Human DNA Topoisomerase I (70 Kda) In Complex With The Poison Camptothecin and Covalent Complex With A 22 Base Pair DNA Duplex 分子名称: 4-ETHYL-4-HYDROXY-1,12-DIHYDRO-4H-2-OXA-6,12A-DIAZA-DIBENZO[B,H]FLUORENE-3,13-DIONE, 5'-D(*(TGP)P*GP*AP*AP*AP*AP*AP*TP*TP*TP*TP*T)-3', 5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*TP*T)-3', ... 著者 Staker, B.L, Feese, M.D, Cushman, M, Pommier, Y, Zembower, D, Stewart, L, Burgin, A.B. 登録日 2004-05-12 公開日 2005-05-31 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Structures of three classes of anticancer agents bound to the human topoisomerase I-DNA covalent complex J.Med.Chem., 48, 2005
1RW2	Three-dimensional structure of Ku80 CTD 分子名称: ATP-dependent DNA helicase II, 80 kDa subunit 著者 Zhang, Z, Hu, W, Cano, L, Lee, T.D, Chen, D.J, Chen, Y. 登録日 2003-12-15 公開日 2003-12-30 最終更新日 2024-05-22 実験手法 SOLUTION NMR 主引用文献 Solution structure of the C-terminal domain of Ku80 suggests important sites for protein-protein interactions. STRUCTURE, 12, 2004
1TL8	Human DNA topoisomerase I (70 kDa) in complex with the indenoisoquinoline AI-III-52 and covalent complex with a 22 base pair DNA duplex 分子名称: 2,3-DIMETHOXY-12H-[1,3]DIOXOLO[5,6]INDENO[1,2-C]ISOQUINOLIN-6-IUM, 5'-D(*(TPC)P*GP*AP*AP*AP*AP*AP*TP*TP*TP*TP*T)-3', 5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*TP*T)-3', ... 著者 Ioanoviciu, A, Antony, S, Pommier, Y, Staker, B.L, Stewart, L, Cushman, M. 登録日 2004-06-09 公開日 2005-06-21 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Synthesis and Mechanism of Action Studies of a Series of Norindenoisoquinoline Topoisomerase I Poisons Reveal an Inhibitor with a Flipped Orientation in the Ternary DNA-Enzyme-Inhibitor Complex As Determined by X-ray Crystallographic Analysis J.Med.Chem., 48, 2005
1V66	Solution structure of human p53 binding domain of PIAS-1 分子名称: Protein inhibitor of activated STAT protein 1 著者 Okubo, S, Hara, F, Tsuchida, Y, Shimotakahara, S, Suzuki, S, Hatanaka, H, Yokoyama, S, Tanaka, H, Yasuda, H, Shindo, H, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2003-11-27 公開日 2004-12-07 最終更新日 2023-12-27 実験手法 SOLUTION NMR 主引用文献 NMR structure of the N-terminal domain of SUMO ligase PIAS1 and its interaction with tumor suppressor p53 and A/T-rich DNA oligomers J.Biol.Chem., 279, 2004
3NQU	Crystal structure of partially trypsinized (CENP-A/H4)2 heterotetramer 分子名称: Histone H3-like centromeric protein A, Histone H4, SULFATE ION 著者 Sekulic, N, Black, B.E. 登録日 2010-06-29 公開日 2010-08-25 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 The structure of (CENP-A-H4)(2) reveals physical features that mark centromeres. Nature, 467, 2010
3N25	The structure of muscle pyruvate kinase in complex with proline, pyruvate, and Mn2+ 分子名称: 1,2-ETHANEDIOL, GLYCEROL, MANGANESE (II) ION, ... 著者 Fenton, A.W, Johnson, T.A, Holyoak, T. 登録日 2010-05-17 公開日 2010-07-28 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.41 Å) 主引用文献 The pyruvate kinase model system, a cautionary tale for the use of osmolyte perturbations to support conformational equilibria in allostery. Protein Sci., 19, 2010
3ODE	Human PARP-1 zinc finger 2 (Zn2) bound to DNA 分子名称: 5'-D(*CP*CP*CP*AP*AP*GP*CP*G)-3', 5'-D(*CP*GP*CP*TP*TP*GP*GP*G)-3', Poly [ADP-ribose] polymerase 1, ... 著者 Pascal, J.M, Langelier, M.-F. 登録日 2010-08-11 公開日 2011-01-12 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.95 Å) 主引用文献 Crystal Structures of Poly(ADP-ribose) Polymerase-1 (PARP-1) Zinc Fingers Bound to DNA: STRUCTURAL AND FUNCTIONAL INSIGHTS INTO DNA-DEPENDENT PARP-1 ACTIVITY. J.Biol.Chem., 286, 2011
3ODC	Human PARP-1 zinc finger 2 (Zn2) bound to DNA 分子名称: 5'-D(*CP*CP*CP*AP*GP*AP*CP*G)-3', 5'-D(*CP*GP*TP*CP*TP*GP*GP*G)-3', Poly [ADP-ribose] polymerase 1, ... 著者 Pascal, J.M, Langelier, M.-F. 登録日 2010-08-11 公開日 2011-01-12 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Crystal Structures of Poly(ADP-ribose) Polymerase-1 (PARP-1) Zinc Fingers Bound to DNA: STRUCTURAL AND FUNCTIONAL INSIGHTS INTO DNA-DEPENDENT PARP-1 ACTIVITY. J.Biol.Chem., 286, 2011
3QHT	Crystal Structure of the Monobody ySMB-1 bound to yeast SUMO 分子名称: GLYCEROL, Monobody ySMB-1, Ubiquitin-like protein SMT3 著者 Koide, S, Gilbreth, R.N. 登録日 2011-01-26 公開日 2011-05-11 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Isoform-specific monobody inhibitors of small ubiquitin-related modifiers engineered using structure-guided library design. Proc.Natl.Acad.Sci.USA, 108, 2011
3O36	Crystal structure of TRIM24 PHD-Bromo complexed with H4(14-19)K16ac peptide 分子名称: Histone H4, Transcription intermediary factor 1-alpha, ZINC ION 著者 Wang, Z, Patel, D.J. 登録日 2010-07-23 公開日 2010-12-15 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 TRIM24 links a non-canonical histone signature to breast cancer. Nature, 468, 2010
3O33	Crystal structure of TRIM24 PHD-Bromo in the free state 分子名称: Transcription intermediary factor 1-alpha, ZINC ION 著者 Wang, Z, Patel, D.J. 登録日 2010-07-23 公開日 2010-12-15 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 TRIM24 links a non-canonical histone signature to breast cancer. Nature, 468, 2010
3QZT	Crystal Structure of BPTF bromo in complex with histone H4K16ac - Form II 分子名称: GLYCEROL, Histone H4, Nucleosome-remodeling factor subunit BPTF 著者 Li, H, Ruthenburg, A.J, Patel, D.J. 登録日 2011-03-07 公開日 2011-06-01 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Recognition of a Mononucleosomal Histone Modification Pattern by BPTF via Multivalent Interactions. Cell(Cambridge,Mass.), 145, 2011
3QX3	Human topoisomerase IIbeta in complex with DNA and etoposide 分子名称: (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol -5-yl 4,6-O-[(1R)-ethylidene]-beta-D-glucopyranoside, DNA (5'-D(P*AP*GP*CP*CP*GP*AP*GP*C)-3'), DNA (5'-D(P*TP*GP*CP*AP*GP*CP*TP*CP*GP*GP*CP*T)-3'), ... 著者 Wu, C.C, Li, T.K, Farh, L, Lin, L.Y, Lin, T.S, Yu, Y.J, Yen, T.J, Chiang, C.W, Chan, N.L. 登録日 2011-03-01 公開日 2011-07-06 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.162 Å) 主引用文献 Structural basis of type II topoisomerase inhibition by the anticancer drug etoposide Science, 333, 2011
3QZS	Crystal Structure of BPTF bromo in complex with histone H4K16ac - Form I 分子名称: Histone H4, Nucleosome-remodeling factor subunit BPTF 著者 Li, H, Ruthenburg, A.J, Patel, D.J. 登録日 2011-03-07 公開日 2011-06-01 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Recognition of a Mononucleosomal Histone Modification Pattern by BPTF via Multivalent Interactions. Cell(Cambridge,Mass.), 145, 2011
3R45	Structure of a CENP-A-Histone H4 Heterodimer in complex with chaperone HJURP 分子名称: GLYCEROL, Histone H3-like centromeric protein A, Histone H4, ... 著者 Hu, H, Liu, Y, Wang, M, Fang, J, Huang, H, Yang, N, Li, Y, Wang, J, Yao, X, Shi, Y, Li, G, Xu, R.M. 登録日 2011-03-17 公開日 2011-04-06 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structure of a CENP-A-histone H4 heterodimer in complex with chaperone HJURP Genes Dev., 25, 2011

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