PDB: 2461 件ウェブページステータス検索Chemie searchBIRD

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6W1S	Atomic model of the mammalian Mediator complex 分子名称: Mediator of RNA polymerase II transcription subunit 1, Mediator of RNA polymerase II transcription subunit 10, Mediator of RNA polymerase II transcription subunit 11, ... 著者 Zhao, H, Young, N, Asturias, F. 登録日 2020-03-04 公開日 2021-03-10 実験手法 ELECTRON MICROSCOPY (4.02 Å) 主引用文献 A Pliable Mediator Acts as a Functional Rather Than an Architectural Bridge between Promoters and Enhancers. Cell, 178, 2019
6TLJ	Cryo-EM structure of the Anaphase-promoting complex/Cyclosome, in complex with the Mitotic checkpoint complex (APC/C-MCC) at 3.8 angstrom resolution 分子名称: Anaphase-promoting complex subunit 1, Anaphase-promoting complex subunit 10, Anaphase-promoting complex subunit 11, ... 著者 Alfieri, C, Barford, D. 登録日 2019-12-02 公開日 2020-02-19 最終更新日 2020-06-17 実験手法 ELECTRON MICROSCOPY (3.8 Å) 主引用文献 A unique binding mode of Nek2A to the APC/C allows its ubiquitination during prometaphase. Embo Rep., 21, 2020
6X08	Nup85-Seh1 from S. cerevisiae bound by VHH-SAN2 分子名称: Nucleoporin NUP85, Nucleoporin SEH1, VHH-SAN2 著者 Nordeen, S.A, Schwartz, T.U. 登録日 2020-05-15 公開日 2020-12-09 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (4.19 Å) 主引用文献 A nanobody suite for yeast scaffold nucleoporins provides details of the nuclear pore complex structure. Nat Commun, 11, 2020
7AY0	Crystal structure of truncated USP1-UAF1 分子名称: Ubiquitin carboxyl-terminal hydrolase 1, WD repeat-containing protein 48, ZINC ION 著者 Arkinson, C, Rennie, M.L, Walden, H. 登録日 2020-11-10 公開日 2021-03-24 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (3.6 Å) 主引用文献 Structural basis of FANCD2 deubiquitination by USP1-UAF1. Nat.Struct.Mol.Biol., 28, 2021
6ZYX	Outer Dynein Arm-Shulin complex - Shulin region from Tetrahymena thermophila 分子名称: Dynein heavy chain, outer arm protein, Dynein intermediate chain 2, ... 著者 Mali, G.R, Abid Ali, F, Lau, C.K, Carter, A.P. 登録日 2020-08-03 公開日 2021-01-20 最終更新日 2024-05-01 実験手法 ELECTRON MICROSCOPY (4.3 Å) 主引用文献 Shulin packages axonemal outer dynein arms for ciliary targeting. Science, 371, 2021
7AD3	Class D GPCR Ste2 dimer coupled to two G proteins 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-factor mating pheromone, CHOLESTEROL HEMISUCCINATE, ... 著者 Velazhahan, V, Tate, C. 登録日 2020-09-14 公開日 2020-12-09 最終更新日 2021-01-13 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 Structure of the class D GPCR Ste2 dimer coupled to two G proteins. Nature, 589, 2021
6ZRC	Structure of the human RBAP48 in complex with a macrocyclic peptide cyclized via a xylene linker attached to two cysteines 分子名称: Histone-binding protein RBBP4, PARA-XYLENE, macrocyclic peptide based on residues 659-672 of the metastasis-associated protein MTA1 著者 Vetter, I.R, Porfetye, A.T. 登録日 2020-07-13 公開日 2020-10-28 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structure Based Design of Bicyclic Peptide Inhibitors of RbAp48. Angew.Chem.Int.Ed.Engl., 60, 2021
6ZWO	cryo-EM structure of human mTOR complex 2, focused on one half 分子名称: ACETYL GROUP, INOSITOL HEXAKISPHOSPHATE, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ... 著者 Scaiola, A, Mangia, F, Imseng, S, Boehringer, D, Ban, N, Maier, T. 登録日 2020-07-28 公開日 2020-11-18 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 The 3.2- angstrom resolution structure of human mTORC2. Sci Adv, 6, 2020
6ZRD	STRUCTURE OF THE HUMAN RBAP48 in complex with a macrocyclic peptide cyclized via a xylene linker attached to two cysteines 分子名称: 1,3,5-trimethylbenzene, Histone-binding protein RBBP4, macrocyclic peptide based on residues 659-672 of the metastasis-associated protein MTA1 著者 Vetter, I.R, Porfetye, A.T. 登録日 2020-07-13 公開日 2020-12-02 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structure Based Design of Bicyclic Peptide Inhibitors of RbAp48. Angew.Chem.Int.Ed.Engl., 60, 2021
6ZWM	cryo-EM structure of human mTOR complex 2, overall refinement 分子名称: ACETYL GROUP, INOSITOL HEXAKISPHOSPHATE, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ... 著者 Scaiola, A, Mangia, F, Imseng, S, Boehringer, D, Ban, N, Maier, T. 登録日 2020-07-28 公開日 2020-11-18 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 The 3.2- angstrom resolution structure of human mTORC2. Sci Adv, 6, 2020
7BYF	The crystal structure of mouse ORF10-Rae1-Nup98 complex 分子名称: 10 protein, MERCURY (II) ION, Peptidase S59 domain-containing protein, ... 著者 Gao, P, Feng, H. 登録日 2020-04-22 公開日 2021-03-24 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Molecular mechanism underlying selective inhibition of mRNA nuclear export by herpesvirus protein ORF10. Proc.Natl.Acad.Sci.USA, 117, 2020
7BGB	The H/ACA RNP lobe of human telomerase 分子名称: H/ACA ribonucleoprotein complex subunit 1, H/ACA ribonucleoprotein complex subunit 2, H/ACA ribonucleoprotein complex subunit 3, ... 著者 Nguyen, T.H.D, Ghanim, G.E, Fountain, A.J, van Roon, A.M.M, Rangan, R, Das, R, Collins, K. 登録日 2021-01-06 公開日 2021-04-28 最終更新日 2024-05-01 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 Structure of human telomerase holoenzyme with bound telomeric DNA. Nature, 593, 2021
7Y5K	Crystal structure of human CAF-1 core complex in spacegroup C2221 分子名称: Chromatin assembly factor 1 subunit A, Chromatin assembly factor 1 subunit B, GLYCEROL, ... 著者 Liu, C.P, Wang, M.Z, Xu, R.M. 登録日 2022-06-17 公開日 2023-08-16 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (3.48 Å) 主引用文献 Structural insights into histone binding and nucleosome assembly by chromatin assembly factor-1. Science, 381, 2023
7Y5O	Crystal structure of human CAF-1 core complex in spacegroup P21 分子名称: Chromatin assembly factor 1 subunit A, Chromatin assembly factor 1 subunit B, GLYCEROL, ... 著者 Liu, C.P, Wang, M.Z, Xu, R.M. 登録日 2022-06-17 公開日 2023-08-16 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (3.57 Å) 主引用文献 Structural insights into histone binding and nucleosome assembly by chromatin assembly factor-1. Science, 381, 2023
7Y5L	Crystal structure of human CAF-1 core complex in spacegroup C2 分子名称: Chromatin assembly factor 1 subunit A, Chromatin assembly factor 1 subunit B, GLYCEROL, ... 著者 Liu, C.P, Wang, M.Z, Xu, R.M. 登録日 2022-06-17 公開日 2023-08-16 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (3.42 Å) 主引用文献 Structural insights into histone binding and nucleosome assembly by chromatin assembly factor-1. Science, 381, 2023
7Z8J	Cytoplasmic dynein (A2) bound to BICDR1 分子名称: BICD family-like cargo adapter 1, Cytoplasmic dynein 1 heavy chain 1, Cytoplasmic dynein 1 intermediate chain 2, ... 著者 Chaaban, S, Carter, A.P. 登録日 2022-03-17 公開日 2022-07-27 最終更新日 2022-10-19 実験手法 ELECTRON MICROSCOPY (3.93 Å) 主引用文献 Structure of dynein-dynactin on microtubules shows tandem adaptor binding. Nature, 610, 2022
7ZGP	Polymerase module of CPF in complex with Mpe1 and a pre-cleaved CYC1 RNA 分子名称: MPE1 isoform 1, Polyadenylation factor subunit 2, Protein CFT1, ... 著者 Rodriguez-Molina, J.B, Passmore, L.A. 登録日 2022-04-04 公開日 2022-05-25 最終更新日 2022-07-20 実験手法 ELECTRON MICROSCOPY (2.7 Å) 主引用文献 Mpe1 senses the binding of pre-mRNA and controls 3' end processing by CPF. Mol.Cell, 82, 2022
7ZGR	Polymerase module of yeast CPF in complex with Mpe1, the yPIM of Cft2 and the pre-cleaved CYC1 RNA 分子名称: Cleavage factor two protein 2, MPE1 isoform 1, Polyadenylation factor subunit 2, ... 著者 Rodriguez-Molina, J.B, Passmore, L.A. 登録日 2022-04-04 公開日 2022-05-25 最終更新日 2022-07-20 実験手法 ELECTRON MICROSCOPY (2.6 Å) 主引用文献 Mpe1 senses the binding of pre-mRNA and controls 3' end processing by CPF. Mol.Cell, 82, 2022
7ZGQ	Polymerase module of yeast CPF in complex with the yPIM of Cft2 分子名称: Cleavage factor two protein 2, Polyadenylation factor subunit 2, Protein CFT1, ... 著者 Rodriguez-Molina, J.B, Passmore, L.A. 登録日 2022-04-04 公開日 2022-05-25 最終更新日 2022-07-20 実験手法 ELECTRON MICROSCOPY (2.8 Å) 主引用文献 Mpe1 senses the binding of pre-mRNA and controls 3' end processing by CPF. Mol.Cell, 82, 2022
7ZU0	HOPS tethering complex from yeast 分子名称: E3 ubiquitin-protein ligase PEP5, Vacuolar membrane protein PEP3, Vacuolar morphogenesis protein 6, ... 著者 Shvarev, D, Schoppe, J, Koenig, C, Perz, A, Fuellbrunn, N, Kiontke, S, Langemeyer, L, Januliene, D, Schnelle, K, Kuemmel, D, Froehlich, F, Moeller, A, Ungermann, C. 登録日 2022-05-11 公開日 2022-09-28 最終更新日 2022-10-12 実験手法 ELECTRON MICROSCOPY (4.4 Å) 主引用文献 Structure of the HOPS tethering complex, a lysosomal membrane fusion machinery. Elife, 11, 2022
7ZV2	HUMAN PRMT5:MEP50 Crystal Structure With MTA and Fragment Bound 分子名称: 5'-DEOXY-5'-METHYLTHIOADENOSINE, GLYCEROL, Methylosome protein 50, ... 著者 Ahmad, M.U, Koelmel, W, Arkhipova, V, Lawson, J.D, Smith, C.R, Gunn, R.J. 登録日 2022-05-13 公開日 2022-10-19 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.01 Å) 主引用文献 Fragment optimization and elaboration strategies - the discovery of two lead series of PRMT5/MTA inhibitors from five fragment hits. Rsc Med Chem, 13, 2022
7ZVL	HUMAN PRMT5:MEP50 Crystal Structure With MTA and Fragment Bound 分子名称: 5'-DEOXY-5'-METHYLTHIOADENOSINE, CHLORIDE ION, GLYCEROL, ... 著者 Ahmad, M.U, Koelmel, W, Arkhipova, V, Lawson, J.D, Smith, C.R, Gunn, R.J. 登録日 2022-05-16 公開日 2022-10-19 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.39 Å) 主引用文献 Fragment optimization and elaboration strategies - the discovery of two lead series of PRMT5/MTA inhibitors from five fragment hits. Rsc Med Chem, 13, 2022
7ZUU	HUMAN PRMT5:MEP50 Crystal Structure With MTA and Fragment Bound 分子名称: 5'-DEOXY-5'-METHYLTHIOADENOSINE, GLYCEROL, Methylosome protein 50, ... 著者 Ahmad, M.U, Koelmel, W, Arkhipova, V, Lawson, J.D, Smith, C.R, Gunn, R.J. 登録日 2022-05-13 公開日 2022-10-19 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.09 Å) 主引用文献 Fragment optimization and elaboration strategies - the discovery of two lead series of PRMT5/MTA inhibitors from five fragment hits. Rsc Med Chem, 13, 2022
7ZUQ	HUMAN PRMT5:MEP50 Crystal Structure With MTA and Fragment Bound 分子名称: 5'-DEOXY-5'-METHYLTHIOADENOSINE, GLYCEROL, Methylosome protein 50, ... 著者 Ahmad, M.U, Koelmel, W, Arkhipova, V, Lawson, J.D, Smith, C.R, Gunn, R.J. 登録日 2022-05-13 公開日 2022-10-19 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.48 Å) 主引用文献 Fragment optimization and elaboration strategies - the discovery of two lead series of PRMT5/MTA inhibitors from five fragment hits. Rsc Med Chem, 13, 2022
7ZUY	HUMAN PRMT5:MEP50 Crystal Structure With MTA and Fragment Bound 分子名称: 5'-DEOXY-5'-METHYLTHIOADENOSINE, GLYCEROL, Methylosome protein 50, ... 著者 Ahmad, M.U, Koelmel, W, Arkhipova, V, Lawson, J.D, Smith, C.R, Gunn, R.J. 登録日 2022-05-13 公開日 2022-10-19 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Fragment optimization and elaboration strategies - the discovery of two lead series of PRMT5/MTA inhibitors from five fragment hits. Rsc Med Chem, 13, 2022

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