PDB: 12060 件ウェブページステータス検索Chemie searchBIRD

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3N49	Human FPPS COMPLEX WITH NOV_292 分子名称: FARNESYL PYROPHOSPHATE SYNTHASE, PHOSPHATE ION, naphtho[2,1-b]thiophen-1-ylacetic acid 著者 Rondeau, J.-M. 登録日 2010-05-21 公開日 2010-08-18 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Allosteric non-bisphosphonate FPPS inhibitors identified by fragment-based discovery. Nat.Chem.Biol., 6, 2010
3AU9	Crystal structure of the quaternary complex-1 of an isomerase 分子名称: 1-deoxy-D-xylulose 5-phosphate reductoisomerase, 3-[FORMYL(HYDROXY)AMINO]PROPYLPHOSPHONIC ACID, CALCIUM ION, ... 著者 Umeda, T, Tanaka, N, Kusakabe, Y, Nakanishi, M, Kitade, Y, Nakamura, K.T. 登録日 2011-02-01 公開日 2011-08-10 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Molecular basis of fosmidomycin's action on the human malaria parasite Plasmodium falciparum Sci Rep, 1, 2011
4TKW	Crystal Structure of Human Transthyretin Leu55Pro Mutant 分子名称: Transthyretin 著者 Saelices, L, Cascio, D, Sawaya, M, Eisenberg, D.S. 登録日 2014-05-27 公開日 2015-10-21 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Uncovering the Mechanism of Aggregation of Human Transthyretin. J.Biol.Chem., 290, 2015
4TL4	Crystal Structure of Human Transthyretin Val30Met Mutant 分子名称: Transthyretin 著者 Saelices, L, Cascio, D, Sawaya, M, Eisenberg, D.S. 登録日 2014-05-28 公開日 2015-10-21 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Uncovering the Mechanism of Aggregation of Human Transthyretin. J.Biol.Chem., 290, 2015
6CRR	CryoEM structure of human enterovirus D68 full native virion (pH 7.2 and 4 degrees Celsius) 分子名称: viral protein 1, viral protein 2, viral protein 3, ... 著者 Liu, Y, Rossmann, M.G. 登録日 2018-03-19 公開日 2018-12-19 最終更新日 2024-03-13 実験手法 ELECTRON MICROSCOPY (3.24 Å) 主引用文献 Molecular basis for the acid-initiated uncoating of human enterovirus D68. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
2I22	Crystal structure of Escherichia coli phosphoheptose isomerase in complex with reaction substrate sedoheptulose 7-phosphate 分子名称: D-ALTRO-HEPT-2-ULOSE 7-PHOSPHATE, Phosphoheptose isomerase 著者 Blakely, K, Zhang, K, DeLeon, G, Wright, G, Junop, M. 登録日 2006-08-15 公開日 2007-08-21 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Structure and Function of Sedoheptulose-7-phosphate Isomerase, a Critical Enzyme for Lipopolysaccharide Biosynthesis and a Target for Antibiotic Adjuvants J.Biol.Chem., 283, 2008
6OKK	Cryo-EM structure of the Plasmodium falciparum 80S ribosome bound to the anti-protozoan drug emetine, small subunit 分子名称: 18S ribosomal RNA, 40S ribosomal protein S10, 40S ribosomal protein S11, ... 著者 Wong, W, Scheres, S.H.W. 登録日 2019-04-13 公開日 2019-05-22 最終更新日 2020-01-08 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Cryo-EM structure of the Plasmodium falciparum 80S ribosome bound to the anti-protozoan drug emetine. Elife, 3, 2014
6CSA	CryoEM structure of human enterovirus D68 emptied particle (pH 5.5 and room temperature) 分子名称: viral protein 1, viral protein 2, viral protein 3 著者 Liu, Y, Rossmann, M.G. 登録日 2018-03-20 公開日 2018-12-19 最終更新日 2024-03-13 実験手法 ELECTRON MICROSCOPY (3.75 Å) 主引用文献 Molecular basis for the acid-initiated uncoating of human enterovirus D68. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6CSG	CryoEM structure of human enterovirus D68 full native virion 分子名称: viral protein 1, viral protein 2, viral protein 3, ... 著者 Liu, Y, Rossmann, M.G. 登録日 2018-03-20 公開日 2018-12-19 最終更新日 2024-03-13 実験手法 ELECTRON MICROSCOPY (2.17 Å) 主引用文献 Molecular basis for the acid-initiated uncoating of human enterovirus D68. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
8J1T	Local refined cryo-EM structure of Omicron BA.5 RBD in complex with 8-9D Fab 分子名称: 8-9D heavy chain, 8-9D light chain, Spike protein 著者 Xiang, Y, Li, R. 登録日 2023-04-13 公開日 2023-11-29 最終更新日 2023-12-20 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 A lung-selective delivery of mRNA encoding broadly neutralizing antibody against SARS-CoV-2 infection. Nat Commun, 14, 2023
3HLO	Crystal structure of chemically synthesized 'covalent dimer' [Gly51/D-Ala51']HIV-1 protease 分子名称: 'covalent dimer' [Gly51/D-Ala51'] HIV-1 protease, N-{(2S)-2-[(N-acetyl-L-threonyl-L-isoleucyl)amino]hexyl}-L-norleucyl-L-glutaminyl-N~5~-[amino(iminio)methyl]-L-ornithinamide 著者 Torbeev, V.Y, Kent, S.B.H. 登録日 2009-05-27 公開日 2011-07-27 最終更新日 2012-12-12 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Protein conformational dynamics in the mechanism of HIV-1 protease catalysis. Proc.Natl.Acad.Sci.USA, 108, 2011
1ZF4	ATC Four-stranded DNA Holliday Junction 分子名称: 5'-D(*CP*CP*GP*AP*TP*AP*TP*CP*GP*G)-3', SODIUM ION 著者 Hays, F.A, Teegarden, A.T, Jones, Z.J.R, Harms, M, Raup, D, Watson, J, Cavaliere, E, Ho, P.S. 登録日 2005-04-19 公開日 2005-05-10 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 How sequence defines structure: a crystallographic map of DNA structure and conformation. Proc.Natl.Acad.Sci.Usa, 102, 2005
1ZFF	TTC Duplex B-DNA 分子名称: 5'-D(*CP*CP*GP*AP*AP*TP*TP*CP*GP*G)-3' 著者 Hays, F.A, Teegarden, A.T, Jones, Z.J.R, Harms, M, Raup, D, Watson, J, Cavaliere, E, Ho, P.S. 登録日 2005-04-20 公開日 2005-05-10 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (0.94 Å) 主引用文献 How sequence defines structure: a crystallographic map of DNA structure and conformation. Proc.Natl.Acad.Sci.Usa, 102, 2005
3NN1	Structure of chlorite dismutase from Candidatus Nitrospira defluvii in complex with imidazole 分子名称: 1,2-ETHANEDIOL, Chlorite dismutase, IMIDAZOLE, ... 著者 Kostan, J, Sjoeblom, B, Maixner, F, Mlynek, G, Furtmueller, P.G, Obinger, C, Wagner, M, Daims, H, Djinovic-Carugo, K. 登録日 2010-06-23 公開日 2010-07-28 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Structural and functional characterisation of the chlorite dismutase from the nitrite-oxidizing bacterium "Candidatus Nitrospira defluvii": Identification of a catalytically important amino acid residue J.Struct.Biol., 172, 2010
3N3L	Human FPPS complex with FBS_03 分子名称: (6-methoxy-1-benzofuran-3-yl)acetic acid, FARNESYL PYROPHOSPHATE SYNTHASE, PHOSPHATE ION 著者 Rondeau, J.-M. 登録日 2010-05-20 公開日 2010-08-18 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.74 Å) 主引用文献 Allosteric non-bisphosphonate FPPS inhibitors identified by fragment-based discovery. Nat.Chem.Biol., 6, 2010
6CS3	CryoEM structure of human enterovirus D68 expanded 1 particle (pH 7.2 and 4 degrees Celsius) 分子名称: viral protein 1, viral protein 2, viral protein 3, ... 著者 Liu, Y, Rossmann, M.G. 登録日 2018-03-19 公開日 2018-12-19 最終更新日 2024-03-13 実験手法 ELECTRON MICROSCOPY (3.31 Å) 主引用文献 Molecular basis for the acid-initiated uncoating of human enterovirus D68. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
8JED	Crystal structure of mRNA cap (guanine-N7) methyltransferase E12 subunit from monkeypox virus and discovery of its inhibitors 分子名称: mRNA-capping enzyme regulatory subunit OPG124 著者 Wang, D, Zhao, R, Shu, W, Hu, W, Wang, M, Cao, J, Zhou, X. 登録日 2023-05-15 公開日 2023-12-06 実験手法 X-RAY DIFFRACTION (2.16 Å) 主引用文献 Crystal structure of mRNA cap (guanine-N7) methyltransferase E12 subunit from monkeypox virus and discovery of its inhibitors. Int.J.Biol.Macromol., 253, 2023
6CS5	CryoEM structure of human enterovirus D68 abortive product 2 (pH 7.2 and 4 degrees Celsius) 分子名称: viral protein 1, viral protein 2, viral protein 3 著者 Liu, Y, Rossmann, M.G. 登録日 2018-03-19 公開日 2018-12-19 最終更新日 2024-03-13 実験手法 ELECTRON MICROSCOPY (3.24 Å) 主引用文献 Molecular basis for the acid-initiated uncoating of human enterovirus D68. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6OKS	CDTb Double Heptamer Long Form Mask 1 Modeled from Cryo-EM Map Reconstructed using C7 Symmetry 分子名称: ADP-ribosyltransferase binding component 著者 Lacy, D.B, Sheedlo, M.J, Anderson, D.M. 登録日 2019-04-15 公開日 2019-10-30 最終更新日 2024-03-20 実験手法 ELECTRON MICROSCOPY (4.2 Å) 主引用文献 Structural insights into the transition of Clostridioides difficile binary toxin from prepore to pore. Nat Microbiol, 5, 2020
3BYM	X-ray co-crystal structure aminobenzimidazole triazine 1 bound to Lck 分子名称: N-phenyl-1-{4-[(3,4,5-trimethoxyphenyl)amino]-1,3,5-triazin-2-yl}-1H-benzimidazol-2-amine, Proto-oncogene tyrosine-protein kinase LCK, SULFATE ION 著者 Huang, X. 登録日 2008-01-16 公開日 2008-09-16 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structure-based design of novel 2-amino-6-phenyl-pyrimido[5',4':5,6]pyrimido[1,2-a]benzimidazol-5(6H)-ones as potent and orally active inhibitors of lymphocyte specific kinase (Lck): synthesis, SAR, and in vivo anti-inflammatory activity. J.Med.Chem., 51, 2008
4RLK	Crystal structure of Z. mays CK2alpha in complex with the ATP-competitive inhibitor 4-[(E)-(fluoren-9-ylidenehydrazinylidene)-methyl] benzoate 分子名称: 4-[(E)-(9H-fluoren-9-ylidenehydrazinylidene)methyl]benzoic acid, ACETATE ION, Casein kinase II subunit alpha, ... 著者 Guerra, B, Rasmussen, T.D.L, Schnitzler, A, Jensen, H.H, Boldyreff, B.S, Miyata, Y, Marcussen, N, Niefind, K, Issinger, O.G. 登録日 2014-10-17 公開日 2014-12-17 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.24 Å) 主引用文献 Protein kinase CK2 inhibition is associated with the destabilization of HIF-1 alpha in human cancer cells. Cancer Lett, 356, 2015
3BYZ	2-Amino-1,3-thiazol-4(5H)-ones as Potent and Selective 11-Hydroxysteroid Dehydrogenase Type 1 Inhibitors 分子名称: (5S)-2-(cyclooctylamino)-5-methyl-5-propyl-1,3-thiazol-4(5H)-one, Corticosteroid 11-beta-dehydrogenase isozyme 1, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE 著者 Zhang, J, Jordan, S.R, Li, V. 登録日 2008-01-16 公開日 2008-02-12 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.69 Å) 主引用文献 2-amino-1,3-thiazol-4(5H)-ones as potent and selective 11beta-hydroxysteroid dehydrogenase type 1 inhibitors: enzyme-ligand co-crystal structure and demonstration of pharmacodynamic effects in C57Bl/6 mice. J.Med.Chem., 51, 2008
2I5S	Crystal structure of onconase with bound nucleic acid 分子名称: 5'-D(*A*(DU)P*GP*A)-3', P-30 protein 著者 Bae, E, Lee, J.E, Raines, R.T, Wesenberg, G.E, Phillips Jr, G.N, Bitto, E, Bingman, C.A, Center for Eukaryotic Structural Genomics (CESG) 登録日 2006-08-25 公開日 2006-09-05 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structural basis for catalysis by onconase. J.Mol.Biol., 375, 2008
8I7V	Cryo-EM structure of Acipimox bound human hydroxy-carboxylic acid receptor 2 in complex with Gi heterotrimer 分子名称: 5-methyl-4-oxidanyl-pyrazin-4-ium-2-carboxylic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Park, J.H, Ishimoto, N, Park, S.Y. 登録日 2023-02-02 公開日 2024-02-07 実験手法 ELECTRON MICROSCOPY (2.77 Å) 主引用文献 Structural basis for ligand recognition and signaling of hydroxy-carboxylic acid receptor 2. Nat Commun, 14, 2023
4RSE	Crystal structure of RPE65 in complex with MB-001 and palmitate 分子名称: (1R)-3-amino-1-{3-[(2,6,6-trimethylcyclohex-1-en-1-yl)methoxy]phenyl}propan-1-ol, FE (II) ION, PALMITIC ACID, ... 著者 Kiser, P.D, Shi, W, Palczewski, K. 登録日 2014-11-07 公開日 2015-04-15 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.39 Å) 主引用文献 Catalytic mechanism of a retinoid isomerase essential for vertebrate vision. Nat.Chem.Biol., 11, 2015

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