4RLK

Crystal structure of Z. mays CK2alpha in complex with the ATP-competitive inhibitor 4-[(E)-(fluoren-9-ylidenehydrazinylidene)-methyl] benzoate

Summary for 4RLK

• Entry DOI: 10.2210/pdb4rlk/pdb
• Related: 4RLL
• Descriptor: Casein kinase II subunit alpha, GLYCEROL, ACETATE ION, ... (5 entities in total)
• Functional Keywords: transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Zea mays (maize)
• Total number of polymer chains: 1
• Total formula weight: 40011.88

Authors

Guerra, B.,Rasmussen, T.D.L.,Schnitzler, A.,Jensen, H.H.,Boldyreff, B.S.,Miyata, Y.,Marcussen, N.,Niefind, K.,Issinger, O.G. (deposition date: 2014-10-17, release date: 2014-12-17, Last modification date: 2023-09-20)

• Primary citation: Guerra, B.,Rasmussen, T.D.,Schnitzler, A.,Jensen, H.H.,Boldyreff, B.S.,Miyata, Y.,Marcussen, N.,Niefind, K.,Issinger, O.G.; Protein kinase CK2 inhibition is associated with the destabilization of HIF-1 alpha in human cancer cells.; Cancer Lett, 356:751-761, 2015; PubMed: 25449433; DOI: 10.1016/j.canlet.2014.10.026

Experimental method

X-RAY DIFFRACTION (1.24 Å)