PDB: 7770 件ウェブページステータス検索Chemie searchBIRD

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3KW9	X-ray structure of Cathepsin K covalently bound to a triazine ligand 分子名称: 4-(cyclohexylamino)-6-piperazin-1-yl-1,3,5-triazine-2-carbonitrile, Cathepsin K, trifluoroacetic acid 著者 Uitdehaag, J.C.M, van Zeeland, M. 登録日 2009-12-01 公開日 2010-03-02 最終更新日 2017-11-01 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Design and optimization of a series of novel 2-cyano-pyrimidines as cathepsin K inhibitors. Bioorg.Med.Chem.Lett., 20, 2010
3B3V	Crystal structure of the S228A mutant of the aminopeptidase from Vibrio proteolyticus 分子名称: Bacterial leucyl aminopeptidase, SODIUM ION, THIOCYANATE ION, ... 著者 Ataie, N.J, Hoang, Q.Q, Zahniser, M.P.D, Milne, A, Petsko, G.A, Ringe, D. 登録日 2007-10-22 公開日 2007-11-27 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.22 Å) 主引用文献 Zinc coordination geometry and ligand binding affinity: the structural and kinetic analysis of the second-shell serine 228 residue and the methionine 180 residue of the aminopeptidase from Vibrio proteolyticus. Biochemistry, 47, 2008
2KRD	Solution Structure of the Regulatory Domain of Human Cardiac Troponin C in Complex with the Switch Region of cardiac Troponin I and W7 分子名称: CALCIUM ION, N-(6-AMINOHEXYL)-5-CHLORO-1-NAPHTHALENESULFONAMIDE, Troponin C, ... 著者 Oleszczuk, M, Robertson, I.M, Li, M.X, Sykes, B.D. 登録日 2009-12-16 公開日 2010-02-16 最終更新日 2024-05-22 実験手法 SOLUTION NMR 主引用文献 Solution structure of the regulatory domain of human cardiac troponin C in complex with the switch region of cardiac troponin I and W7: the basis of W7 as an inhibitor of cardiac muscle contraction. J.MOL.CELL.CARDIOL., 48, 2010
3B6R	Crystal structure of Human Brain-type Creatine Kinase 分子名称: ACETATE ION, ADENOSINE-5'-DIPHOSPHATE, Creatine kinase B-type, ... 著者 Bong, S.M, Moon, J.H, Hwang, K.Y. 登録日 2007-10-29 公開日 2008-11-04 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural studies of human brain-type creatine kinase complexed with the ADP-Mg2+-NO3- -creatine transition-state analogue complex Febs Lett., 582, 2008
3B4M	Crystal Structure of Human PABPN1 RRM 分子名称: Polyadenylate-binding protein 2 著者 Ge, H, Zhou, D, Teng, M, Niu, L. 登録日 2007-10-24 公開日 2008-01-15 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.82 Å) 主引用文献 Crystal structure and possible dimerization of the single RRM of human PABPN1 Proteins, 71, 2008
3BC3	Exploring inhibitor binding at the S subsites of cathepsin L 分子名称: Cathepsin L heavy and light chains, S-benzyl-N-(biphenyl-4-ylacetyl)-L-cysteinyl-N~5~-(diaminomethyl)-D-ornithyl-N-(2-phenylethyl)-L-tyrosinamide 著者 Chowdhury, S.F, Joseph, L, Kumar, S, Tulsidas, S.R, Bhat, S, Ziomek, E, Nard, R.M, Sivaraman, J, Purisima, E.O. 登録日 2007-11-12 公開日 2008-03-18 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Exploring inhibitor binding at the S' subsites of cathepsin L J.Med.Chem., 51, 2008
3BCH	Crystal Structure of the Human Laminin Receptor Precursor 分子名称: 40S ribosomal protein SA 著者 Jamieson, K.V, Wu, J, Hubbard, S.R, Meruelo, D. 登録日 2007-11-12 公開日 2007-12-04 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Crystal structure of the human laminin receptor precursor. J.Biol.Chem., 283, 2008
3B68	Crystal structure of the androgen receptor ligand binding domain in complex with SARM S-4 分子名称: (2S)-3-[4-(acetylamino)phenoxy]-2-hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide, Androgen receptor 著者 Bohl, C.E, Miller, D.D, Dalton, J.T. 登録日 2007-10-27 公開日 2008-09-09 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Effect of B-ring substitution pattern on binding mode of propionamide selective androgen receptor modulators Bioorg.Med.Chem.Lett., 18, 2008
3KWV	Structural basis for the unfolding of anthrax lethal factor by protective antigen oligomers 分子名称: CALCIUM ION, Lethal factor, Protective antigen PA-63 著者 Feld, G.K, Kintzer, A.F, Krantz, B.A. 登録日 2009-12-01 公開日 2010-11-10 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (3.101 Å) 主引用文献 Structural basis for the unfolding of anthrax lethal factor by protective antigen oligomers. Nat.Struct.Mol.Biol., 17, 2010
2KSR	NMR structures of TM domain of the n-Acetylcholine receptor b2 subunit 分子名称: Neuronal acetylcholine receptor subunit beta-2 著者 Bondarenko, V, Tillman, T, Xu, Y, Tang, P. 登録日 2010-01-12 公開日 2010-06-16 最終更新日 2024-05-22 実験手法 SOLUTION NMR 主引用文献 NMR structure of the transmembrane domain of the n-acetylcholine receptor beta2 subunit. Biochim.Biophys.Acta, 1798, 2010
2KUM	Solution structure of the human chemokine CCL27 分子名称: C-C motif chemokine 27 著者 Kirkpatrick, J.P, Jansma, A, Hsu, A, Handel, T.M, Nietlispach, D. 登録日 2010-02-22 公開日 2010-03-02 最終更新日 2022-03-16 実験手法 SOLUTION NMR 主引用文献 NMR analysis of the structure, dynamics, and unique oligomerization properties of the chemokine CCL27. J.Biol.Chem., 285, 2010
3D4D	Crystal structure of Staphylococcal nuclease variant Delta+PHS Y91E at cryogenic temperature 分子名称: CALCIUM ION, THYMIDINE-3',5'-DIPHOSPHATE, Thermonuclease 著者 Khangulov, V.S, Schlessman, J.L, Garcia-Moreno, E.B. 登録日 2008-05-14 公開日 2008-11-04 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Crystal structure of Staphylococcal nuclease variant Delta+PHS Y91E at cryogenic temperature. To be Published
3D4N	Crystal Structure of Human 11-beta-Hydroxysteroid Dehydrogenase (HSD1) in Complex with Sulfonamide Inhibitor 分子名称: 1-{[(3R)-3-methyl-4-({4-[(1S)-2,2,2-trifluoro-1-hydroxy-1-methylethyl]phenyl}sulfonyl)piperazin-1-yl]methyl}cyclopropanecarboxamide, Corticosteroid 11-beta-dehydrogenase isozyme 1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE 著者 Wang, Z, Liu, J, Sudom, A, Walker, N.P. 登録日 2008-05-14 公開日 2008-07-22 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Discovery of Novel, Potent Benzamide Inhibitors of 11beta-Hydroxysteroid Dehydrogenase Type 1 (11beta-HSD1) Exhibiting Oral Activity in an Enzyme Inhibition ex Vivo Model J.Med.Chem., 51, 2008
2KR6	Solution structure of presenilin-1 CTF subunit 分子名称: Presenilin-1 著者 Doetsch, V. 登録日 2009-12-04 公開日 2010-04-28 最終更新日 2024-05-08 実験手法 SOLUTION NMR 主引用文献 Solution structure of presenilin-1 CTF subunit To be Published
3CM7	Crystal Structure of XIAP-BIR3 domain in complex with Smac-mimetic compuond, Smac005 分子名称: (3S,6S,7S,9aS)-6-{[(2S)-2-aminobutanoyl]amino}-N-(diphenylmethyl)-7-(hydroxymethyl)-5-oxooctahydro-1H-pyrrolo[1,2-a]azepine-3-carboxamide, Baculoviral IAP repeat-containing protein 4, ZINC ION 著者 Mastrangelo, E, Cossu, F, Milani, M. 登録日 2008-03-21 公開日 2008-10-28 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Targeting the X-linked inhibitor of apoptosis protein through 4-substituted azabicyclo[5.3.0]alkane smac mimetics. Structure, activity, and recognition principles. J.Mol.Biol., 384, 2008
3L1F	Bovine AlphaA crystallin 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, Alpha-crystallin A chain 著者 Laganowsky, A, Sawaya, M.R, Cascio, D, Eisenberg, D. 登録日 2009-12-11 公開日 2010-05-12 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.53 Å) 主引用文献 Crystal structures of truncated alphaA and alphaB crystallins reveal structural mechanisms of polydispersity important for eye lens function. Protein Sci., 19, 2010
2KVU	Solution NMR Structure of SAP domain of MKL/myocardin-like protein 1 from H.sapiens, Northeast Structural Genomics Consortium Target Target HR4547E 分子名称: MKL/myocardin-like protein 1 著者 Liu, G, Xiao, R, Janjua, J, Acton, T.B, Mao, B, Everett, J, Montelione, G.T, Northeast Structural Genomics Consortium (NESG) 登録日 2010-03-28 公開日 2010-04-21 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 Northeast Structural Genomics Consortium Target HR4547E To be Published
2XM9	Structure of a small molecule inhibitor with the kinase domain of Chk2 分子名称: 4-(1H-pyrazol-5-yl)-2-{4-[(3S)-pyrrolidin-3-ylamino]quinazolin-2-yl}phenol, NITRATE ION, SERINE/THREONINE-PROTEIN KINASE CHK2 著者 Caldwell, J.J, Welsh, E.J, Matijssen, C, Anderson, V.E, Antoni, L, Boxall, K, Urban, F, Hayes, A, Raynaud, F.I, Rigoreau, L.J, Raynham, T, Aherne, G.W, Pearl, L.H, Oliver, A.W, Garrett, M.D, Collins, I. 登録日 2010-07-26 公開日 2011-01-12 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structure-Based Design of Potent and Selective 2-(Quinazolin-2-Yl)Phenol Inhibitors of Checkpoint Kinase 2. J.Med.Chem., 54, 2011
3KSE	Unreduced cathepsin L in complex with stefin A 分子名称: Cathepsin L1, Cystatin-A 著者 Renko, M, Turk, D. 登録日 2009-11-22 公開日 2010-12-01 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.71 Å) 主引用文献 Unreduced cathepsin L in complex with stefin A To be Published
3L1E	Bovine AlphaA crystallin Zinc Bound 分子名称: Alpha-crystallin A chain, GLYCEROL, ZINC ION 著者 Laganowsky, A, Sawaya, M.R, Cascio, D, Eisenberg, D. 登録日 2009-12-11 公開日 2010-05-12 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.15 Å) 主引用文献 Crystal structures of truncated alphaA and alphaB crystallins reveal structural mechanisms of polydispersity important for eye lens function. Protein Sci., 19, 2010
2XVG	crystal structure of alpha-xylosidase (GH31) from Cellvibrio japonicus 分子名称: 1,2-ETHANEDIOL, ALPHA XYLOSIDASE, CHLORIDE ION, ... 著者 Larsbrink, J, Izumi, A, Ibatullin, F, Nakhai, A, Gilbert, H.J, Davies, G.J, Brumer, H. 登録日 2010-10-26 公開日 2011-04-13 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structural and Enzymatic Characterisation of a Glycoside Hydrolase Family 31 Alpha-Xylosidase from Cellvibrio Japonicus Involved in Xyloglucan Saccharification. Biochem.J., 436, 2011
3L1K	SAD structure solution of proteinase K grown in potassium tellurate solution 分子名称: 1,2-ETHANEDIOL, CALCIUM ION, Orthotelluric acid, ... 著者 Jakoncic, J. 登録日 2009-12-11 公開日 2010-12-22 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 SAD structure solution of proteinase K grown in potassium tellurate solution To be Published
3LE9	Crystal structure of the catalytic domain of TACE with Indazolinone-phenyl-hydantoin inhibitor 分子名称: (5R)-5-[(5-methoxy-3-oxo-1,3-dihydro-2H-indazol-2-yl)methyl]-5-phenylimidazolidine-2,4-dione, Disintegrin and metalloproteinase domain-containing protein 17, ISOPROPYL ALCOHOL, ... 著者 Orth, P. 登録日 2010-01-14 公開日 2010-12-08 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Biaryl substituted hydantoin compounds as TACE inhibitors. Bioorg.Med.Chem.Lett., 20, 2010
3LFL	Crystal Structure of human Glutathione Transferase Omega 1, delta 155 分子名称: 2,3-DIHYDROXY-1,4-DITHIOBUTANE, GLUTATHIONE, Glutathione S-transferase omega-1 著者 Brock, J. 登録日 2010-01-18 公開日 2010-11-24 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Novel folding and stability defects cause a deficiency of human glutathione transferase omega 1. J.Biol.Chem., 286, 2011
3D07	Human p53 core domain with hot spot mutation R249S (III) 分子名称: Cellular tumor antigen p53, ZINC ION 著者 Suad, O, Rozenberg, H, Shakked, Z. 登録日 2008-05-01 公開日 2009-01-20 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structural basis of restoring sequence-specific DNA binding and transactivation to mutant p53 by suppressor mutations J.Mol.Biol., 385, 2009

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