Summary for 3KW9
| Related | 3KWB |
|---|---|
| Descriptor | Cathepsin K, 4-(cyclohexylamino)-6-piperazin-1-yl-1,3,5-triazine-2-carbonitrile, trifluoroacetic acid, ... (4 entities in total) |
| Functional Keywords | cysteine, thioimidate, disulfide bond, cys protease, inhibitor, non-peptide, hydrolase, protease, thiol protease, zymogen |
| Biological source | Homo sapiens (human) |
| Cellular location | Lysosome P43235 |
| Total number of polymer chains | 1 |
| Total molecular weight | 23924.87 |
| Authors | Uitdehaag, J.C.M.,van Zeeland, M. (deposition date: 2009-12-01, release date: 2010-03-02, Last modification date: 2017-11-01) |
| Primary citation | Rankovic, Z.,Cai, J.,Kerr, J.,Fradera, X.,Robinson, J.,Mistry, A.,Hamilton, E.,McGarry, G.,Andrews, F.,Caulfield, W.,Cumming, I.,Dempster, M.,Waller, J.,Scullion, P.,Martin, I.,Mitchell, A.,Long, C.,Baugh, M.,Westwood, P.,Kinghorn, E.,Bruin, J.,Hamilton, W.,Uitdehaag, J.,van Zeeland, M.,Potin, D.,Saniere, L.,Fouquet, A.,Chevallier, F.,Deronzier, H.,Dorleans, C.,Nicolai, E. Design and optimization of a series of novel 2-cyano-pyrimidines as cathepsin K inhibitors. Bioorg.Med.Chem.Lett., 20:1524-1527, 2010 PubMed: 20149657 (PDB entries with the same primary citation) DOI: 10.1016/j.bmcl.2010.01.100  Import into Mendeley |
| Experimental method | X-RAY DIFFRACTION (1.8 Å) |
