3D4N

Crystal Structure of Human 11-beta-Hydroxysteroid Dehydrogenase (HSD1) in Complex with Sulfonamide Inhibitor

Summary for 3D4N

Entry DOI	10.2210/pdb3d4n/pdb
Related	3CZR 3D3E
Descriptor	Corticosteroid 11-beta-dehydrogenase isozyme 1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 1-{[(3R)-3-methyl-4-({4-[(1S)-2,2,2-trifluoro-1-hydroxy-1-methylethyl]phenyl}sulfonyl)piperazin-1-yl]methyl}cyclopropanecarboxamide, ... (4 entities in total)
Functional Keywords	oxidoreductase, 11beta, hydroxysteroid, dehydrogenase, endoplasmic reticulum, glycoprotein, lipid metabolism, membrane, microsome, nadp, polymorphism, signal-anchor, steroid metabolism, transmembrane
Biological source	Homo sapiens (Human)
Cellular location	Endoplasmic reticulum membrane; Single-pass type II membrane protein: P28845
Total number of polymer chains	4
Total formula weight	132119.07
Authors	Wang, Z.,Liu, J.,Sudom, A.,Walker, N.P. (deposition date: 2008-05-14, release date: 2008-07-22, Last modification date: 2024-02-21)
Primary citation	Julian, L.D.,Wang, Z.,Bostick, T.,Caille, S.,Choi, R.,Degraffenreid, M.,Di, Y.,He, X.,Hungate, R.W.,Jaen, J.C.,Liu, J.,Monshouwer, M.,McMinn, D.,Rew, Y.,Sudom, A.,Sun, D.,Tu, H.,Ursu, S.,Walker, N.,Yan, X.,Ye, Q.,Powers, J.P. Discovery of Novel, Potent Benzamide Inhibitors of 11beta-Hydroxysteroid Dehydrogenase Type 1 (11beta-HSD1) Exhibiting Oral Activity in an Enzyme Inhibition ex Vivo Model J.Med.Chem., 51:3953-3960, 2008 Cited by PubMed: 18553955 DOI: 10.1021/jm800310g PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation