2KRD

Solution Structure of the Regulatory Domain of Human Cardiac Troponin C in Complex with the Switch Region of cardiac Troponin I and W7

Summary for 2KRD

• Entry DOI: 10.2210/pdb2krd/pdb
• Descriptor: Troponin C, slow skeletal and cardiac muscles, Troponin I, cardiac muscle, CALCIUM ION, ... (4 entities in total)
• Functional Keywords: cardiac troponin c, regulatory domain, troponin i, switch region, w7, acetylation, calcium, cardiomyopathy, disease mutation, muscle protein, polymorphism, actin-binding, phosphoprotein, structural protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 12257.43

Authors

Oleszczuk, M.,Robertson, I.M.,Li, M.X.,Sykes, B.D. (deposition date: 2009-12-16, release date: 2010-02-16, Last modification date: 2022-03-16)

• Primary citation: Oleszczuk, M.,Robertson, I.M.,Li, M.X.,Sykes, B.D.; Solution structure of the regulatory domain of human cardiac troponin C in complex with the switch region of cardiac troponin I and W7: the basis of W7 as an inhibitor of cardiac muscle contraction.; J.MOL.CELL.CARDIOL., 48:925-933, 2010; PubMed: 20116385; DOI: 10.1016/j.yjmcc.2010.01.016

Experimental method

SOLUTION NMR