3BC3
Exploring inhibitor binding at the S subsites of cathepsin L
Summary for 3BC3
Entry DOI | 10.2210/pdb3bc3/pdb |
Related | 1MHW |
Descriptor | Cathepsin L heavy and light chains, S-benzyl-N-(biphenyl-4-ylacetyl)-L-cysteinyl-N~5~-(diaminomethyl)-D-ornithyl-N-(2-phenylethyl)-L-tyrosinamide (3 entities in total) |
Functional Keywords | cathepsin l inhibitor binding at the s subsites, glycoprotein, hydrolase, lysosome, protease, thiol protease, zymogen |
Biological source | Homo sapiens (human) |
Cellular location | Lysosome: P07711 |
Total number of polymer chains | 2 |
Total formula weight | 50107.50 |
Authors | Chowdhury, S.F.,Joseph, L.,Kumar, S.,Tulsidas, S.R.,Bhat, S.,Ziomek, E.,Nard, R.M.,Sivaraman, J.,Purisima, E.O. (deposition date: 2007-11-12, release date: 2008-03-18, Last modification date: 2023-08-30) |
Primary citation | Chowdhury, S.F.,Joseph, L.,Kumar, S.,Tulsidas, S.R.,Bhat, S.,Ziomek, E.,Menard, R.,Sivaraman, J.,Purisima, E.O. Exploring inhibitor binding at the S' subsites of cathepsin L J.Med.Chem., 51:1361-1368, 2008 Cited by PubMed: 18278855DOI: 10.1021/jm701190v PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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