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3BC3

Exploring inhibitor binding at the S subsites of cathepsin L

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, B
(A, B)
Cathepsin L heavy and light chainspolymer22024223.72UniProt (P07711)
Pfam (PF00112)
Homo sapiens (human)(EC 3.4.22.15) (Major excreted protein) (MEP)
2C, D
(A, B)
S-benzyl-N-(biphenyl-4-ylacetyl)-L-cysteinyl-N~5~-(diaminomethyl)-D-ornithyl-N-(2-phenylethyl)-L-tyrosinamidenon-polymer830.02Chemie (OPT)
3E, F
(A, B)
waterwater18.0423Chemie (HOH)
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight48447.4
Non-Polymers*Number of molecules2
Total formula weight1660.1
All*Total formula weight50107.5
*Water molecules are not included.

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PDB entries from 2025-07-30

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