PDB: 222415 件ウェブページステータス検索Chemie searchBIRD

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4NQ4	Bacillus cereus Zn-dependent metallo-beta-lactamase at pH 7 分子名称: Beta-lactamase 2, POTASSIUM ION, ZINC ION 著者 Gonzalez, J.M, Gonzalez, M.M, Vila, A.J. 登録日 2013-11-23 公開日 2014-11-26 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.67 Å) 主引用文献 Inhibition of metallo-lactamases with bicyclic compounds TO BE PUBLISHED
4NUY	Crystal structure of EndoS, an endo-beta-N-acetyl-glucosaminidase from Streptococcus pyogenes 分子名称: CALCIUM ION, Endo-beta-N-acetylglucosaminidase F2 著者 Trastoy, B, Guenther, S, Snyder, G.A, Sundberg, E.J. 登録日 2013-12-04 公開日 2014-04-09 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.609 Å) 主引用文献 Crystal structure of Streptococcus pyogenes EndoS, an immunomodulatory endoglycosidase specific for human IgG antibodies. Proc.Natl.Acad.Sci.USA, 111, 2014
4NVE	Predicting protein conformational response in prospective ligand discovery 分子名称: BENZIMIDAZOLE, Cytochrome c peroxidase, PROTOPORPHYRIN IX CONTAINING FE 著者 Fischer, M, Fraser, J.S. 登録日 2013-12-05 公開日 2013-12-18 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.54 Å) 主引用文献 Incorporation of protein flexibility and conformational energy penalties in docking screens to improve ligand discovery. Nat Chem, 6, 2014
4NQM	Crystal Structure of the first bromodomain of human BRD4 in complex with a triazolo-phthalazine ligand 分子名称: 2-chloro-N-[5-(3-methyl[1,2,4]triazolo[3,4-a]phthalazin-6-yl)-2-(morpholin-4-yl)phenyl]benzenesulfonamide, Bromodomain-containing protein 4, SUCCINIC ACID 著者 Filippakopoulos, P, Picaud, S, Felletar, I, Martin, S, Fedorov, O, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Knapp, S, Structural Genomics Consortium (SGC) 登録日 2013-11-25 公開日 2013-12-18 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.58 Å) 主引用文献 Crystal Structure of the first bromodomain of human BRD4 in complex with a triazolo-phthalazine ligand To be Published
4NVO	Predicting protein conformational response in prospective ligand discovery 分子名称: 3-(thiophen-2-yl)-6,7-dihydro-5H-pyrrolo[1,2-a]imidazole, Cytochrome c peroxidase, PROTOPORPHYRIN IX CONTAINING FE 著者 Fischer, M, Fraser, J.S. 登録日 2013-12-05 公開日 2013-12-25 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.71 Å) 主引用文献 Incorporation of protein flexibility and conformational energy penalties in docking screens to improve ligand discovery. Nat Chem, 6, 2014
4NR8	Crystal structure of the first bromodomain of human BRD4 in complex with an isoxazolyl-benzimidazole ligand 分子名称: 1,2-ETHANEDIOL, 5-(3,5-dimethyl-1,2-oxazol-4-yl)-1-[2-(morpholin-4-yl)ethyl]-2-(2-phenylethyl)-1H-benzimidazole, Bromodomain-containing protein 4, ... 著者 Filippakopoulos, P, Picaud, S, Felletar, I, Hay, D, Fedorov, O, Martin, S, von Delft, F, Brennan, P, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Knapp, S, Structural Genomics Consortium (SGC) 登録日 2013-11-26 公開日 2013-12-25 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.635 Å) 主引用文献 Crystal structure of the first bromodomain of human BRD4 in complex with an isoxazolyl-benzimidazole ligand To be Published
4NWJ	Crystal structure of phosphopglycerate mutase from Staphylococcus aureus in 3-phosphoglyceric acid bound form. 分子名称: 2,3-bisphosphoglycerate-independent phosphoglycerate mutase, 3-PHOSPHOGLYCERIC ACID, MANGANESE (II) ION 著者 Roychowdhury, A, Bose, M, Kundu, A, Gujar, A, Das, A.K. 登録日 2013-12-06 公開日 2015-01-14 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.01 Å) 主引用文献 Complete catalytic cycle of cofactor-independent phosphoglycerate mutase involves a spring-loaded mechanism Febs J., 282, 2015
4NSN	Crystal structure of purine nucleoside phosphorylase from Porphyromonas gingivalis ATCC 33277, NYSGRC Target 030972, orthorhombic symmetry 分子名称: ADENINE, Purine nucleoside phosphorylase, SULFATE ION 著者 Malashkevich, V.N, Bhosle, R, Toro, R, Hillerich, B, Gizzi, A, Garforth, S, Kar, A, Chan, M.K, Lafluer, J, Patel, H, Matikainen, B, Chamala, S, Lim, S, Celikgil, A, Villegas, G, Evans, B, Love, J, Fiser, A, Seidel, R, Bonanno, J.B, Almo, S.C, New York Structural Genomics Research Consortium (NYSGRC) 登録日 2013-11-28 公開日 2013-12-25 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Crystal structure of purine nucleoside phosphorylase from Porphyromonas gingivalis ATCC 33277, NYSGRC Target 030972, orthorhombic symmetry. To be Published
4EYT	Crystal structure of the C-terminal domain of Tetrahymena telomerase protein p65 分子名称: SULFATE ION, Telomerase associated protein p65 著者 Singh, M, Wang, Z, Koo, B.-K, Patel, A, Cascio, D, Collins, K, Feigon, J. 登録日 2012-05-01 公開日 2012-06-20 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structural Basis for Telomerase RNA Recognition and RNP Assembly by the Holoenzyme La Family Protein p65. Mol.Cell, 47, 2012
4NVG	Predicting protein conformational response in prospective ligand discovery 分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Cytochrome c peroxidase, PHOSPHATE ION, ... 著者 Fischer, M, Fraser, J.S. 登録日 2013-12-05 公開日 2013-12-18 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.742 Å) 主引用文献 Incorporation of protein flexibility and conformational energy penalties in docking screens to improve ligand discovery. Nat Chem, 6, 2014
4F15	Molecular basis of infectivity of 2009 pandemic H1N1 influenza A viruses 分子名称: Fab fragment, heavy chain, light chain, ... 著者 Kim, K.H, Cho, K.J, Lee, J.H, Park, Y.H, Khan, T.G, Lee, J.Y, Kang, S.H, Alam, I. 登録日 2012-05-06 公開日 2013-05-15 最終更新日 2017-11-15 実験手法 X-RAY DIFFRACTION (2.81 Å) 主引用文献 Molecular basis of infectivity of 2009 pandemic H1N1 influenza A viruses To be Published
4NWW	Crystal structure of an N-terminally truncated capsid protein mutant of Orsay virus 分子名称: CALCIUM ION, Capsid protein 著者 Tao, Y.J, Guo, Y.R. 登録日 2013-12-06 公開日 2014-08-20 最終更新日 2017-11-22 実験手法 X-RAY DIFFRACTION (3.75 Å) 主引用文献 Crystal structure of a nematode-infecting virus. Proc.Natl.Acad.Sci.USA, 111, 2014
4O2Z	Crystal Structure of MPK3 from Leishmania donovani, LdBPK_100540 in the presence of NVP-BBT594 分子名称: 5-{[6-(acetylamino)pyrimidin-4-yl]oxy}-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}-2,3-dihydro-1H-indole-1-carboxamide, Mitogen-activated protein kinase 3, putative 著者 Wernimont, A.K, Walker, J.R, Hutchinson, A, Loppnau, P, Edwards, A.M, Arrowsmith, C.H, Bountra, C, Hui, R, Mangos, M, Structural Genomics Consortium (SGC) 登録日 2013-12-17 公開日 2014-01-22 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.71 Å) 主引用文献 Crystal Structure of MPK3 from Leishmania donovani, LdBPK_100540 in the presence of NVP-BBT594 To be Published
4NCH	Crystal Structure of Pyrococcus furiosis Rad50 L802W mutation 分子名称: DNA double-strand break repair Rad50 ATPase, SULFATE ION 著者 Classen, S, Williams, G.J, Arvai, A.S, Williams, R.S. 登録日 2013-10-24 公開日 2014-03-05 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 ATP-driven Rad50 conformations regulate DNA tethering, end resection, and ATM checkpoint signaling. Embo J., 33, 2014
4F3J	Crystal Structure of Trimeric gC1q Domain of Human C1QTNF5 associated with Late-onset Retinal Macular Degeneration 分子名称: Complement C1q tumor necrosis factor-related protein 5 著者 Tu, X, Palczewski, K. 登録日 2012-05-09 公開日 2012-11-07 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.337 Å) 主引用文献 Crystal structure of the globular domain of C1QTNF5: Implications for late-onset retinal macular degeneration. J.Struct.Biol., 180, 2012
4O0J	HIV-1 Integrase Catalytic Core Domain Complexed with Allosteric Inhibitor (2S)-tert-butoxy[4-(4-chlorophenyl)-6-(3,4-dimethylphenyl)-2,5-dimethylpyridin-3-yl]ethanoic acid 分子名称: (2S)-tert-butoxy[4-(4-chlorophenyl)-6-(3,4-dimethylphenyl)-2,5-dimethylpyridin-3-yl]ethanoic acid, Integrase, SULFATE ION 著者 Feng, L, Kvaratskhelia, M. 登録日 2013-12-13 公開日 2014-07-02 最終更新日 2017-11-22 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 A New Class of Multimerization Selective Inhibitors of HIV-1 Integrase. Plos Pathog., 10, 2014
4EZA	Crystal structure of the atypical phosphoinositide (aPI) binding domain of IQGAP2 分子名称: Ras GTPase-activating-like protein IQGAP2 著者 Van Aalten, D.M.F, Dixon, M.J, Gray, A, Schenning, M, Agacan, M, Leslie, N.R, Downes, C.P, Batty, I.H, Nedyalkova, L, Tempel, W, Tong, Y, Zhong, N, Crombet, L, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC) 登録日 2012-05-02 公開日 2012-05-16 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 IQGAP Proteins Reveal an Atypical Phosphoinositide (aPI) Binding Domain with a Pseudo C2 Domain Fold. J.Biol.Chem., 287, 2012
4F08	Discovery and Optimization of C-2 Methyl Imidazo-pyrrolopyridines as Potent and Orally Bioavailable JAK1 Inhibitors with Selectivity over JAK2 分子名称: 1-(piperidin-4-yl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine, Tyrosine-protein kinase JAK2 著者 Murray, J.M. 登録日 2012-05-03 公開日 2012-07-04 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (2.82 Å) 主引用文献 Discovery and Optimization of C-2 Methyl Imidazopyrrolopyridines as Potent and Orally Bioavailable JAK1 Inhibitors with Selectivity over JAK2. J.Med.Chem., 55, 2012
4F46	Crystal structure of wild type human CD38 in complex with NAADP and ADPRP 分子名称: ADP-ribosyl cyclase 1, [[(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-3-oxidanyl-4-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2R,3S,4R,5R)-5-(3-carboxypyridin-1-ium-1-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl phosphate, [[(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-3-oxidanyl-4-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2R,3S,4R,5S)-3,4,5-tris(oxidanyl)oxolan-2-yl]methyl hydrogen phosphate 著者 Zhang, H, Lee, H.C, Hao, Q. 登録日 2012-05-10 公開日 2013-04-03 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.69 Å) 主引用文献 Crystal Structures of Human CD38 in Complex with NAADP and ADPRP MESSENGER, 2, 2013
4NH3	Structure of human Dicer Platform-PAZ-Connector Helix cassette in complex with 13-mer siRNA having 5'-pU and UU-3' ends (2.6 Angstrom resolution) 分子名称: 5'-R(P*UP*GP*CP*GP*AP*AP*UP*UP*CP*GP*CP*UP*U)-3', Endoribonuclease Dicer 著者 Simanshu, D.K, Tian, Y, Patel, D.J. 登録日 2013-11-04 公開日 2014-03-05 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.616 Å) 主引用文献 A Phosphate-Binding Pocket within the Platform-PAZ-Connector Helix Cassette of Human Dicer. Mol.Cell, 53, 2014
4NIQ	Crystal Structure of Vps4 MIT-Vfa1 MIM2 分子名称: VPS4-associated protein 1, Vacuolar protein sorting-associated protein 4 著者 Vild, C.J, Xu, Z. 登録日 2013-11-06 公開日 2014-03-05 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.301 Å) 主引用文献 Vfa1 Binds to the N-terminal Microtubule-interacting and Trafficking (MIT) Domain of Vps4 and Stimulates Its ATPase Activity. J.Biol.Chem., 289, 2014
4NIX	Crystal structure of trypsiligase (K60E/N143H/Y151H/D189K trypsin) orthorhombic form, zinc-bound 分子名称: CALCIUM ION, Cationic trypsin, GLYCEROL, ... 著者 Schoepfel, M, Parthier, C, Stubbs, M.T. 登録日 2013-11-08 公開日 2014-02-19 最終更新日 2014-03-19 実験手法 X-RAY DIFFRACTION (1.3 Å) 主引用文献 N-terminal protein modification by substrate-activated reverse proteolysis. Angew.Chem.Int.Ed.Engl., 53, 2014
4F32	Crystal structure of 3-oxoacyl-[acyl-carrier-protein] synthase II from Burkholderia vietnamiensis in complex with platencin 分子名称: 1,2-ETHANEDIOL, 2,4-dihydroxy-3-({3-[(2S,4aS,8S,8aR)-8-methyl-3-methylidene-7-oxo-1,3,4,7,8,8a-hexahydro-2H-2,4a-ethanonaphthalen-8-yl]propanoyl}amino)benzoic acid, 3-oxoacyl-[acyl-carrier-protein] synthase 2, ... 著者 Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2012-05-08 公開日 2012-05-23 最終更新日 2014-02-12 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Combining functional and structural genomics to sample the essential Burkholderia structome. Plos One, 8, 2013
4NJ8	Crystal structure of the human ANKS3 SAM Domain L52A mutant 分子名称: Ankyrin repeat and SAM domain-containing protein 3 著者 Leettola, C.N, Cascio, D, Bowie, J.U. 登録日 2013-11-08 公開日 2014-07-16 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Characterization of the SAM domain of the PKD-related protein ANKS6 and its interaction with ANKS3. Bmc Struct.Biol., 14, 2014
4NK6	Crystal Structure of the periplasmic alginate epimerase AlgG 分子名称: Poly(beta-D-mannuronate) C5 epimerase 著者 Howell, P.L, Wolfram, F, Robinson, H. 登録日 2013-11-12 公開日 2014-01-15 最終更新日 2014-03-19 実験手法 X-RAY DIFFRACTION (2.0974 Å) 主引用文献 Catalytic Mechanism and Mode of Action of the Periplasmic Alginate Epimerase AlgG. J.Biol.Chem., 289, 2014

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