4NQM
Crystal Structure of the first bromodomain of human BRD4 in complex with a triazolo-phthalazine ligand
Summary for 4NQM
Entry DOI | 10.2210/pdb4nqm/pdb |
Related | 4NQN |
Descriptor | Bromodomain-containing protein 4, 2-chloro-N-[5-(3-methyl[1,2,4]triazolo[3,4-a]phthalazin-6-yl)-2-(morpholin-4-yl)phenyl]benzenesulfonamide, SUCCINIC ACID, ... (4 entities in total) |
Functional Keywords | structural genomics consortium, sgc, bromodomain, inhibition, transcription, small molecule inhibitor, transcription-inhibitor complex, transcription/inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus: O60885 |
Total number of polymer chains | 1 |
Total formula weight | 15752.48 |
Authors | Filippakopoulos, P.,Picaud, S.,Felletar, I.,Martin, S.,Fedorov, O.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2013-11-25, release date: 2013-12-18, Last modification date: 2024-02-28) |
Primary citation | Filippakopoulos, P.,Picaud, S.,Felletar, I.,Martin, S.,Fedorov, O.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Knapp, S. Crystal Structure of the first bromodomain of human BRD4 in complex with a triazolo-phthalazine ligand To be Published, |
Experimental method | X-RAY DIFFRACTION (1.58 Å) |
Structure validation
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