PDB: 66878 件ウェブページステータス検索Chemie searchBIRD

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4U6Z	HsMetAP(F309M) in complex with 1-amino-2-propylpentyl)phosphonic acid 分子名称: COBALT (II) ION, GLYCEROL, Methionine aminopeptidase 1, ... 著者 Arya, T, Addlagatta, A. 登録日 2014-07-30 公開日 2015-04-15 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Identification of the Molecular Basis of Inhibitor Selectivity between the Human and Streptococcal Type I Methionine Aminopeptidases J.Med.Chem., 58, 2015
4TXS	An Ligand-observed Mass Spectrometry-based Approach Integrated into the Fragment Based Lead Discovery Pipeline 分子名称: (4-hydroxyphenyl)acetonitrile, Polyprotein 著者 Shui, W, Yang, C, Lin, J, Chen, X, Qin, S, Chen, S. 登録日 2014-07-07 公開日 2015-05-06 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.78 Å) 主引用文献 A ligand-observed mass spectrometry approach integrated into the fragment based lead discovery pipeline Sci Rep, 5, 2015
7D6T	X-ray structure of Clostridium perfringens sortase C with the C-terminal cell wall sorting motif. 分子名称: Sortase family protein 著者 Kamitori, S, Tamai, E. 登録日 2020-10-01 公開日 2021-06-02 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.68 Å) 主引用文献 X-ray structures of Clostridium perfringens sortase C with C-terminal cell wall sorting motif of LPST demonstrate role of subsite for substrate-binding and structural variations of catalytic site. Biochem.Biophys.Res.Commun., 554, 2021
2BZS	Binding of anti-cancer prodrug CB1954 to the activating enzyme NQO2 revealed by the crystal structure of their complex. 分子名称: 5-(AZIRIDIN-1-YL)-2,4-DINITROBENZAMIDE, FLAVIN-ADENINE DINUCLEOTIDE, NRH DEHYDROGENASE [QUINONE] 2, ... 著者 Abu Khader, M.M, Heap, J.T, De Matteis, C, Kellam, B, Doughty, S.W, Minton, N, Paoli, M. 登録日 2005-08-22 公開日 2005-09-23 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Binding of the Anticancer Prodrug Cb1954 to the Activating Enzyme Nqo2 Revealed by the Crystal Structure of Their Complex. J.Med.Chem., 48, 2005
4TY8	An Ligand-observed Mass Spectrometry-based Approach Integrated into the Fragment Based Lead Discovery Pipeline 分子名称: 6-methyl-2H-chromen-2-one, Polyprotein 著者 Shui, W, Yang, C, Lin, J, Chen, X, Qin, S, Chen, S. 登録日 2014-07-08 公開日 2015-05-06 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.78 Å) 主引用文献 A ligand-observed mass spectrometry approach integrated into the fragment based lead discovery pipeline Sci Rep, 5, 2015
7D36	Crystal Structure of BACE1 in complex with N-{3-[(3S)-1-amino-5-fluoro-3-methyl-3,4-dihydro-2,6-naphthyridin-3-yl]-4-fluorophenyl}-5-cyano-3-methylpyridine-2-carboxamide 分子名称: Beta-secretase 1, GLYCEROL, IODIDE ION, ... 著者 Nakahara, K, Mitsuoka, Y, Kasuya, S, Yamamoto, T, Yamamoto, S, Ito, H, Kido, Y, Kusakabe, K.I. 登録日 2020-09-18 公開日 2021-07-28 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Balancing potency and basicity by incorporating fluoropyridine moieties: Discovery of a 1-amino-3,4-dihydro-2,6-naphthyridine BACE1 inhibitor that affords robust and sustained central A beta reduction. Eur.J.Med.Chem., 216, 2021
7M2N	Crystal structure of Human Lactate Dehydrogenase A with Inhibitor Compound 15 分子名称: 1,2-ETHANEDIOL, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, 5-[(5'-{1-(4-carboxy-1,3-thiazol-2-yl)-5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]-1H-pyrazol-3-yl}-2'-fluoro[1,1'-biphenyl]-4-yl)oxy]-1H-1,2,3-triazole-4-carboxylic acid, ... 著者 Gumpena, R, Ding, J, Powell, D.A, Lowther, W.T. 登録日 2021-03-17 公開日 2021-07-14 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Dual Glycolate Oxidase/Lactate Dehydrogenase A Inhibitors for Primary Hyperoxaluria ACS Medicinal Chemistry Letters, 12, 2021
7M2O	Crystal structure of Human Glycolate Oxidase with Inhibitor Compound 15 分子名称: 1,2-ETHANEDIOL, 5-[(5'-{1-(4-carboxy-1,3-thiazol-2-yl)-5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]-1H-pyrazol-3-yl}-2'-fluoro[1,1'-biphenyl]-4-yl)oxy]-1H-1,2,3-triazole-4-carboxylic acid, DI(HYDROXYETHYL)ETHER, ... 著者 Gumpena, R, Ding, J, Powell, D.A, Lowther, W.T. 登録日 2021-03-17 公開日 2021-07-14 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.07 Å) 主引用文献 Dual Glycolate Oxidase/Lactate Dehydrogenase A Inhibitors for Primary Hyperoxaluria ACS Medicinal Chemistry Letters, 12, 2021
4U6J	HsMetAP in complex with methionine 分子名称: COBALT (II) ION, GLYCEROL, METHIONINE, ... 著者 Arya, T, Addlagatta, A. 登録日 2014-07-29 公開日 2015-03-25 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (1.56 Å) 主引用文献 Identification of the Molecular Basis of Inhibitor Selectivity between the Human and Streptococcal Type I Methionine Aminopeptidases J.Med.Chem., 58, 2015
4U69	HsMetAP complex with (1-amino-2-methylpentyl)phosphonic acid 分子名称: COBALT (II) ION, Methionine aminopeptidase 1, POTASSIUM ION, ... 著者 Arya, T, Addlagatta, A. 登録日 2014-07-28 公開日 2015-03-25 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Identification of the Molecular Basis of Inhibitor Selectivity between the Human and Streptococcal Type I Methionine Aminopeptidases J.Med.Chem., 58, 2015
4U6T	Crystal structure of the Clostridium histolyticum colH collagenase polycystic kidney disease-like domain 2a at 1.76 Angstrom resolution 分子名称: 3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL, ColH protein 著者 Bauer, R, Janowska, K, Sakon, J, Matsushita, O, Latimer, E. 登録日 2014-07-29 公開日 2015-03-11 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (1.76 Å) 主引用文献 Structures of three polycystic kidney disease-like domains from Clostridium histolyticum collagenases ColG and ColH. Acta Crystallogr.,Sect.D, 71, 2015
4U70	HsMetAP (F309M) in complex with (1-amino-2-cyclohexylethyl)phosphonic acid 分子名称: COBALT (II) ION, Methionine aminopeptidase 1, POTASSIUM ION, ... 著者 Arya, T, Addlagatta, A. 登録日 2014-07-30 公開日 2015-03-25 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Identification of the Molecular Basis of Inhibitor Selectivity between the Human and Streptococcal Type I Methionine Aminopeptidases J.Med.Chem., 58, 2015
4U76	HsMetAP (F309M) holo form 分子名称: COBALT (II) ION, GLYCEROL, Methionine aminopeptidase 1, ... 著者 Arya, T, Addlagatta, A. 登録日 2014-07-30 公開日 2015-03-25 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (1.87 Å) 主引用文献 Identification of the Molecular Basis of Inhibitor Selectivity between the Human and Streptococcal Type I Methionine Aminopeptidases J.Med.Chem., 58, 2015
4UAI	Crystal structure of CXCL12 in complex with inhibitor 分子名称: 1-phenyl-3-[4-(1H-tetrazol-5-yl)phenyl]urea, SULFATE ION, Stromal cell-derived factor 1 著者 Smith, E.W, Chen, Y. 登録日 2014-08-09 公開日 2014-11-12 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structural Analysis of a Novel Small Molecule Ligand Bound to the CXCL12 Chemokine. J.Med.Chem., 57, 2014
4U73	HsMetAP(F309M) IN COMPLEX WITH (amino(phenyl)methyl)phosphonic acid 分子名称: COBALT (II) ION, Methionine aminopeptidase 1, POTASSIUM ION, ... 著者 Arya, T, Addlagatta, A. 登録日 2014-07-30 公開日 2015-03-25 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Identification of the Molecular Basis of Inhibitor Selectivity between the Human and Streptococcal Type I Methionine Aminopeptidases J.Med.Chem., 58, 2015
4U7K	Crystal structure of the Clostridium histolyticum colH collagenase polycystic kidney disease-like domain 2a in the presence of calcium at 1.9 Angstrom resolution 分子名称: CALCIUM ION, ColH protein 著者 Bauer, R, Janowska, K, Sakon, J, Matsushita, O, Latimer, E. 登録日 2014-07-31 公開日 2015-03-11 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (1.91 Å) 主引用文献 Structures of three polycystic kidney disease-like domains from Clostridium histolyticum collagenases ColG and ColH. Acta Crystallogr.,Sect.D, 71, 2015
4UBQ	Crystal Structure of IMP-2 Metallo-beta-Lactamase from Acinetobacter spp. 分子名称: ACETATE ION, Beta-lactamase, ZINC ION 著者 Yamaguchi, Y, Matsueda, S, Matsunaga, K, Takashio, N, Toma-Fukai, S, Yamagata, Y, Shibata, N, Wachino, J, Shibayama, K, Arakawa, Y, Kurosaki, H. 登録日 2014-08-13 公開日 2014-12-24 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Crystal structure of IMP-2 metallo-beta-lactamase from Acinetobacter spp.: comparison of active-site loop structures between IMP-1 and IMP-2. Biol.Pharm.Bull., 38, 2015
7BFL	X-ray structure of SS-RNase-2 des116-120 分子名称: Angiogenin-1 著者 Sica, F, Russo Krauss, I, Troisi, R. 登録日 2021-01-04 公開日 2021-04-28 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.88 Å) 主引用文献 The structural features of an ancient ribonuclease from Salmo salar reveal an intriguing case of auto-inhibition. Int.J.Biol.Macromol., 182, 2021
7BFK	X-ray structure of SS-RNase-2 分子名称: Angiogenin-1 著者 Sica, F, Russo Krauss, I, Troisi, R. 登録日 2021-01-04 公開日 2021-04-28 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.89 Å) 主引用文献 The structural features of an ancient ribonuclease from Salmo salar reveal an intriguing case of auto-inhibition. Int.J.Biol.Macromol., 182, 2021
4LHI	Crystal structure of human carbonic anhydrase isozyme II with 5-(phenylsulfonyl)thiophene-2-sulfonamide 分子名称: 5-(phenylsulfonyl)thiophene-2-sulfonamide, Carbonic anhydrase 2, DIMETHYL SULFOXIDE, ... 著者 Smirnov, A, Manakova, E, Grazulis, S. 登録日 2013-07-01 公開日 2014-07-02 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Crystal structure of human carbonic anhydrase isozyme II with 5-(phenylsulfonyl)thiophene-2-sulfonamide To be Published
4U6C	HsMetAP in complex with [(1R)-1-amino-3-cyclopentylpropyl]phosphonic acid 分子名称: COBALT (II) ION, GLYCEROL, Methionine aminopeptidase 1, ... 著者 Arya, T, Addlagatta, A. 登録日 2014-07-28 公開日 2015-03-25 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (1.91 Å) 主引用文献 Identification of the Molecular Basis of Inhibitor Selectivity between the Human and Streptococcal Type I Methionine Aminopeptidases J.Med.Chem., 58, 2015
4V5X	The cryo-EM structure of a 3D DNA-origami object 分子名称: SCAFFOLD STRAND,SCAFFOLD STRAND, STAPLE STRAND 著者 Bai, X.C, Martin, T.G, Scheres, S.H.W, Dietz, H. 登録日 2012-10-09 公開日 2014-07-09 最終更新日 2024-05-08 実験手法 ELECTRON MICROSCOPY (11.5 Å) 主引用文献 Cryo-Em Structure of a 3D DNA-Origami Object. Proc.Natl.Acad.Sci.USA, 109, 2012
7NC7	Crystal structure of fructose-bisphosphate aldolases FBAC from Bacillus methanolicus 分子名称: 1,3-DIHYDROXYACETONEPHOSPHATE, Fructose-bisphosphate aldolase 著者 Einsle, O, Zhang, L, Guetle, D, Jacquot, J.P. 登録日 2021-01-28 公開日 2021-02-17 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Interrogating the Role of the Two Distinct Fructose-Bisphosphate Aldolases of Bacillus methanolicus by Site-Directed Mutagenesis of Key Amino Acids and Gene Repression by CRISPR Interference Front Microbiol, 12, 2021
7ECC	M4 family peptidase PlM4P-mature form 分子名称: CALCIUM ION, M4 family peptidase, PHOSPHATE ION, ... 著者 Yang, J. 登録日 2021-03-12 公開日 2021-04-28 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 M4 family peptidase PlM4P-mature form To Be Published
2W3L	Crystal Structure of Chimaeric Bcl2-xL and Phenyl Tetrahydroisoquinoline Amide Complex 分子名称: 1-(2-{[(3S)-3-(aminomethyl)-3,4-dihydroisoquinolin-2(1H)-yl]carbonyl}phenyl)-4-chloro-5-methyl-N,N-diphenyl-1H-pyrazole-3-carboxamide, APOPTOSIS REGULATOR BCL-2 著者 Porter, J, Payne, A, de Candole, B, Ford, D, Hutchinson, B, Trevitt, G, Turner, J, Edwards, C, Watkins, C, Whitcombe, I, Davis, J, Stubberfield, C, Fisher, M, Lamers, M. 登録日 2008-11-13 公開日 2008-12-09 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Tetrahydroisoquinoline Amide Substituted Phenyl Pyrazoles as Selective Bcl-2 Inhibitors. Bioorg.Med.Chem.Lett., 19, 2009

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