7M2O

Crystal structure of Human Glycolate Oxidase with Inhibitor Compound 15

Summary for 7M2O

• Entry DOI: 10.2210/pdb7m2o/pdb
• Descriptor: Hydroxyacid oxidase 1, FLAVIN MONONUCLEOTIDE, 5-[(5'-{1-(4-carboxy-1,3-thiazol-2-yl)-5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]-1H-pyrazol-3-yl}-2'-fluoro[1,1'-biphenyl]-4-yl)oxy]-1H-1,2,3-triazole-4-carboxylic acid, ... (6 entities in total)
• Functional Keywords: oxidoreductase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 44396.81

Authors

Gumpena, R.,Ding, J.,Powell, D.A.,Lowther, W.T. (deposition date: 2021-03-17, release date: 2021-07-14, Last modification date: 2023-10-18)

• Primary citation: Ding, J.,Gumpena, R.,Boily, M.O.,Caron, A.,Chong, O.,Cox, J.H.,Dumais, V.,Gaudreault, S.,Graff, A.H.,King, A.,Knight, J.,Oballa, R.,Surendradoss, J.,Tang, T.,Wu, J.,Lowther, W.T.,Powell, D.A.; Dual Glycolate Oxidase/Lactate Dehydrogenase A Inhibitors for Primary Hyperoxaluria; ACS Medicinal Chemistry Letters, 12:1116-1123, 2021; DOI: 10.1021/acsmedchemlett.1c00196

Experimental method

X-RAY DIFFRACTION (2.07 Å)