7M2O

Crystal structure of Human Glycolate Oxidase with Inhibitor Compound 15

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Hydroxyacid oxidase 1	polymer	387	42640.1	1	UniProt (Q9UJM8) Pfam (PF01070)	Homo sapiens (Human)	HAOX1,Glycolate oxidase,GOX
2	B (A)	FLAVIN MONONUCLEOTIDE	non-polymer		456.3	1	Chemie (FMN)
3	C (A)	5-[(5'-{1-(4-carboxy-1,3-thiazol-2-yl)-5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]-1H-pyrazol-3-yl}-2'-fluoro[1,1'-biphenyl]-4-yl)oxy]-1H-1,2,3-triazole-4-carboxylic acid	non-polymer		733.7	1	Chemie (YOJ)
4	D, F, G, J (A)	1,2-ETHANEDIOL	non-polymer		62.1	4	Chemie (EDO)
5	E, H, I (A)	DI(HYDROXYETHYL)ETHER	non-polymer		106.1	3	Chemie (PEG)
6	K (A)	water	water		18.0	200	Chemie (HOH)

Sequence modifications

A: 1 - 370 (UniProt: Q9UJM8)

PDB	External Database	Details
Gly -16	-	expression tag
Ser -15	-	expression tag
His -14	-	expression tag
Met -13	-	expression tag
Ala -12	-	expression tag
Ser -11	-	expression tag
Met -10	-	expression tag
Thr -9	-	expression tag
Gly -8	-	expression tag
Gly -7	-	expression tag
Gln -6	-	expression tag
Gln -5	-	expression tag
Met -4	-	expression tag
Gly -3	-	expression tag
Arg -2	-	expression tag
Gly -1	-	expression tag
Ser 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	42640.1
Non-Polymers*	Number of molecules	9
	Total formula weight	1756.7
All*	Total formula weight	44396.8

*Water molecules are not included.