PDB: 22634 件ウェブページステータス検索Chemie searchBIRD

---

4WYC	Crystal structure of 7,8-diaminopelargonic acid synthase (BioA) from Mycobacterium tuberculosis, complexed with a thiazole benzamide inhibitor 分子名称: 1,2-ETHANEDIOL, 4-(1H-imidazol-1-yl)benzamide, Adenosylmethionine-8-amino-7-oxononanoate aminotransferase, ... 著者 Finzel, B.C, Dai, R, Geders, T.W. 登録日 2014-11-17 公開日 2015-07-08 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Fragment-Based Exploration of Binding Site Flexibility in Mycobacterium tuberculosis BioA. J.Med.Chem., 58, 2015
4WZF	Crystal structural basis for Rv0315, an immunostimulatory antigen and pseudo beta-1, 3-glucanase of Mycobacterium tuberculosis 分子名称: 1,2-ETHANEDIOL, 1,3-beta-glucanase, CALCIUM ION 著者 Dong, W.Y, Fu, Z.F, Peng, G.Q. 登録日 2014-11-19 公開日 2015-12-09 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (1.699 Å) 主引用文献 Crystal structural basis for Rv0315, an immunostimulatory antigen and inactive beta-1,3-glucanase of Mycobacterium tuberculosis. Sci Rep, 5, 2015
1OB2	E. coli elongation factor EF-Tu complexed with the antibiotic kirromycin, a GTP analog, and Phe-tRNA 分子名称: ELONGATION FACTOR TU, KIRROMYCIN, MAGNESIUM ION, ... 著者 Kristensen, O, Nissen, P, Nyborg, J. 登録日 2003-01-24 公開日 2004-05-27 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (3.35 Å) 主引用文献 Kirromycin Defines a Specific Domain Arrangement of Elongation Factor EF-TU To be Published
4WYD	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase from Mycobacterium tuberculosis complexed with a fragment from DSF screening 分子名称: 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Adenosylmethionine-8-amino-7-oxononanoate aminotransferase, ... 著者 Dai, R, Finzel, B.C, Geders, T.W. 登録日 2014-11-17 公開日 2015-07-15 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.35 Å) 主引用文献 Fragment-Based Exploration of Binding Site Flexibility in Mycobacterium tuberculosis BioA. J.Med.Chem., 58, 2015
4X0E	Structure of M. tuberculosis nicotinate mono nucleotide adenylyltransferase 分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Probable nicotinate-nucleotide adenylyltransferase, SULFATE ION 著者 Zuccola, H.J, Ostermna, A.L. 登録日 2014-11-21 公開日 2015-01-28 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.41 Å) 主引用文献 Mycobacterial nicotinate mononucleotide adenylyltransferase: structure, mechanism, and implications for drug discovery. J. Biol. Chem., 290, 2015
8EM5	Mycobacterium thermoresistible MmpS5 分子名称: DODECAETHYLENE GLYCOL, GLYCEROL, IODIDE ION, ... 著者 Cuthbert, B.J, Goulding, C.W. 登録日 2022-09-26 公開日 2023-09-27 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 The structure of Mycobacterium thermoresistibile MmpS5 reveals a conserved disulfide bond across mycobacteria. Metallomics, 16, 2024
8G08	Cryo-EM structure of SQ31f-bound Mycobacterium smegmatis ATP synthase rotational state 1 (backbone model) 分子名称: 3-[4-(morpholin-4-yl)phenyl]-4-{[(pyridin-2-yl)methyl]amino}cyclobut-3-ene-1,2-dione, ADENOSINE-5'-TRIPHOSPHATE, ATP synthase epsilon chain, ... 著者 Courbon, G.M, Rubinstein, J.L. 登録日 2023-01-31 公開日 2023-02-15 最終更新日 2024-06-19 実験手法 ELECTRON MICROSCOPY (2.8 Å) 主引用文献 Mechanism of mycobacterial ATP synthase inhibition by squaramides and second generation diarylquinolines. Embo J., 42, 2023
8G09	Cryo-EM structure of SQ31f-bound Mycobacterium smegmatis ATP synthase rotational state 2 (backbone model) 分子名称: 3-[4-(morpholin-4-yl)phenyl]-4-{[(pyridin-2-yl)methyl]amino}cyclobut-3-ene-1,2-dione, ADENOSINE-5'-TRIPHOSPHATE, ATP synthase epsilon chain, ... 著者 Courbon, G.M, Rubinstein, J.L. 登録日 2023-01-31 公開日 2023-02-15 最終更新日 2024-06-19 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Mechanism of mycobacterial ATP synthase inhibition by squaramides and second generation diarylquinolines. Embo J., 42, 2023
8G0C	Cryo-EM structure of TBAJ-876-bound Mycobacterium smegmatis ATP synthase rotational state 1 (backbone model) 分子名称: (1R,2S)-1-(6-bromo-2-methoxyquinolin-3-yl)-2-(2,6-dimethoxypyridin-4-yl)-4-(dimethylamino)-1-(2,3,6-trimethoxypyridin-4-yl)butan-2-ol, ADENOSINE-5'-TRIPHOSPHATE, ATP synthase epsilon chain, ... 著者 Courbon, G.M, Rubinstein, J.L. 登録日 2023-01-31 公開日 2023-02-15 最終更新日 2024-06-19 実験手法 ELECTRON MICROSCOPY (2.8 Å) 主引用文献 Mechanism of mycobacterial ATP synthase inhibition by squaramides and second generation diarylquinolines. Embo J., 42, 2023
8G0E	Cryo-EM structure of TBAJ-876-bound Mycobacterium smegmatis ATP synthase rotational state 3 分子名称: (1R,2S)-1-(6-bromo-2-methoxyquinolin-3-yl)-2-(2,6-dimethoxypyridin-4-yl)-4-(dimethylamino)-1-(2,3,6-trimethoxypyridin-4-yl)butan-2-ol, ADENOSINE-5'-TRIPHOSPHATE, ATP synthase epsilon chain, ... 著者 Courbon, G.M, Rubinstein, J.L. 登録日 2023-01-31 公開日 2023-02-15 最終更新日 2024-06-19 実験手法 ELECTRON MICROSCOPY (2.6 Å) 主引用文献 Mechanism of mycobacterial ATP synthase inhibition by squaramides and second generation diarylquinolines. Embo J., 42, 2023
8G0A	Cryo-EM structure of SQ31f-bound Mycobacterium smegmatis ATP synthase rotational state 3 分子名称: 3-[4-(morpholin-4-yl)phenyl]-4-{[(pyridin-2-yl)methyl]amino}cyclobut-3-ene-1,2-dione, ADENOSINE-5'-TRIPHOSPHATE, ATP synthase epsilon chain, ... 著者 Courbon, G.M, Rubinstein, J.L. 登録日 2023-01-31 公開日 2023-02-15 最終更新日 2024-06-19 実験手法 ELECTRON MICROSCOPY (2.9 Å) 主引用文献 Mechanism of mycobacterial ATP synthase inhibition by squaramides and second generation diarylquinolines. Embo J., 42, 2023
8G0D	Cryo-EM structure of TBAJ-876-bound Mycobacterium smegmatis ATP synthase rotational state 2 (backbone model) 分子名称: (1R,2S)-1-(6-bromo-2-methoxyquinolin-3-yl)-2-(2,6-dimethoxypyridin-4-yl)-4-(dimethylamino)-1-(2,3,6-trimethoxypyridin-4-yl)butan-2-ol, ADENOSINE-5'-TRIPHOSPHATE, ATP synthase epsilon chain, ... 著者 Courbon, G.M, Rubinstein, J.L. 登録日 2023-01-31 公開日 2023-02-15 最終更新日 2024-06-19 実験手法 ELECTRON MICROSCOPY (2.9 Å) 主引用文献 Mechanism of mycobacterial ATP synthase inhibition by squaramides and second generation diarylquinolines. Embo J., 42, 2023
8G0B	Cryo-EM structure of TBAJ-876-bound Mycobacterium smegmatis ATP synthase FO region 分子名称: (1R,2S)-1-(6-bromo-2-methoxyquinolin-3-yl)-2-(2,6-dimethoxypyridin-4-yl)-4-(dimethylamino)-1-(2,3,6-trimethoxypyridin-4-yl)butan-2-ol, ATP synthase subunit a, ATP synthase subunit b, ... 著者 Courbon, G.M, Rubinstein, J.L. 登録日 2023-01-31 公開日 2023-02-15 最終更新日 2024-06-19 実験手法 ELECTRON MICROSCOPY (2.8 Å) 主引用文献 Mechanism of mycobacterial ATP synthase inhibition by squaramides and second generation diarylquinolines. Embo J., 42, 2023
8G07	Cryo-EM structure of SQ31f-bound Mycobacterium smegmatis ATP synthase FO region 分子名称: 3-[4-(morpholin-4-yl)phenyl]-4-{[(pyridin-2-yl)methyl]amino}cyclobut-3-ene-1,2-dione, ATP synthase subunit a, ATP synthase subunit b, ... 著者 Courbon, G.M, Rubinstein, J.L. 登録日 2023-01-31 公開日 2023-02-15 最終更新日 2024-06-19 実験手法 ELECTRON MICROSCOPY (2.8 Å) 主引用文献 Mechanism of mycobacterial ATP synthase inhibition by squaramides and second generation diarylquinolines. Embo J., 42, 2023
8D6Y	Structure of the Mycobacterium tuberculosis 20S proteasome bound to the ADP-bound Mpa ATPase 分子名称: AAA ATPase forming ring-shaped complexes, Proteasome subunit alpha, Proteasome subunit beta, ... 著者 Xiao, X, Li, H. 登録日 2022-06-06 公開日 2022-08-03 最終更新日 2023-08-16 実験手法 ELECTRON MICROSCOPY (10 Å) 主引用文献 The beta-Grasp Domain of Proteasomal ATPase Mpa Makes Critical Contacts with the Mycobacterium tuberculosis 20S Core Particle to Facilitate Degradation. Msphere, 7, 2022
8D6X	Structure of the Mycobacterium tuberculosis 20S proteasome bound to the ATP-bound Mpa ATPase 分子名称: AAA ATPase forming ring-shaped complexes, Proteasome subunit alpha, Proteasome subunit beta, ... 著者 Xiao, X, Li, H. 登録日 2022-06-06 公開日 2022-08-03 最終更新日 2024-06-12 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 The beta-Grasp Domain of Proteasomal ATPase Mpa Makes Critical Contacts with the Mycobacterium tuberculosis 20S Core Particle to Facilitate Degradation. Msphere, 7, 2022
8E74	Mycobacterium tuberculosis RNAP paused elongation complex with NusG transcription factor 分子名称: DNA (54-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... 著者 Delbeau, M, Darst, S.A, Campbell, E.A. 登録日 2022-08-23 公開日 2023-03-22 最終更新日 2023-10-11 実験手法 ELECTRON MICROSCOPY (2.94 Å) 主引用文献 Structural and functional basis of the universal transcription factor NusG pro-pausing activity in Mycobacterium tuberculosis. Mol.Cell, 83, 2023
8E82	Mycobacterium tuberculosis RNAP elongation complex with NusG transcription factor 分子名称: DNA (54-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... 著者 Delbeau, M, Darst, S.A, Campbell, E.A. 登録日 2022-08-25 公開日 2023-03-22 最終更新日 2023-10-11 実験手法 ELECTRON MICROSCOPY (3.03 Å) 主引用文献 Structural and functional basis of the universal transcription factor NusG pro-pausing activity in Mycobacterium tuberculosis. Mol.Cell, 83, 2023
8D6W	Structure of the Mycobacterium tuberculosis 20S proteasome bound to the C-terminal GQYL motif of the ADP-bound Mpa ATPase 分子名称: Proteasome subunit alpha, Proteasome subunit beta, Proteasome-associated ATPase 著者 Xiao, X, Li, H. 登録日 2022-06-06 公開日 2022-08-03 最終更新日 2024-06-12 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 The beta-Grasp Domain of Proteasomal ATPase Mpa Makes Critical Contacts with the Mycobacterium tuberculosis 20S Core Particle to Facilitate Degradation. Msphere, 7, 2022
8D6V	Structure of the Mycobacterium tuberculosis 20S proteasome bound to the C-terminal GQYL motif of the ATP-bound Mpa ATPase 分子名称: Proteasome subunit alpha, Proteasome subunit beta, Proteasome-associated ATPase 著者 Xiao, X, Li, H. 登録日 2022-06-06 公開日 2022-08-03 最終更新日 2024-06-12 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 The beta-Grasp Domain of Proteasomal ATPase Mpa Makes Critical Contacts with the Mycobacterium tuberculosis 20S Core Particle to Facilitate Degradation. Msphere, 7, 2022
8E8M	Mycobacterium tuberculosis RNAP paused elongation complex 分子名称: DNA (54-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... 著者 Delbeau, M, Darst, S.A, Campbell, E.A. 登録日 2022-08-25 公開日 2023-03-22 最終更新日 2024-10-09 実験手法 ELECTRON MICROSCOPY (3.13 Å) 主引用文献 Structural and functional basis of the universal transcription factor NusG pro-pausing activity in Mycobacterium tuberculosis. Mol.Cell, 83, 2023
8E95	Mycobacterium tuberculosis RNAP elongation complex 分子名称: DNA (25-MER), DNA (33-MER), DNA-directed RNA polymerase subunit alpha, ... 著者 Delbeau, M, Darst, S.A, Campbell, E.A. 登録日 2022-08-26 公開日 2023-03-22 最終更新日 2023-10-11 実験手法 ELECTRON MICROSCOPY (2.9 Å) 主引用文献 Structural and functional basis of the universal transcription factor NusG pro-pausing activity in Mycobacterium tuberculosis. Mol.Cell, 83, 2023
4RRU	Myc3 N-terminal JAZ-binding domain[5-242] from arabidopsis 分子名称: CALCIUM ION, Transcription factor MYC3 著者 Ke, J, Zhang, F, Zhou, X.E, Brunzelle, J.S, Zhou, M, Xu, H.E, Melcher, K, He, S.Y. 登録日 2014-11-06 公開日 2015-08-12 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structural basis of JAZ repression of MYC transcription factors in jasmonate signalling. Nature, 525, 2015
8B9U	Structure of ClpC1 NTD from Mycobacterium tuberculosis 分子名称: (MLE)V(MAA)(E9M)G, ATP-dependent Clp protease ATP-binding subunit ClpC1, FORMIC ACID 著者 Meinhart, A, Hoi, D.M, Clausen, T. 登録日 2022-10-10 公開日 2023-07-05 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Clp-targeting BacPROTACs impair mycobacterial proteostasis and survival. Cell, 186, 2023
8BTW	Structure of D179N BlaC from Mycobacterium tuberculosis in complex with vaborbactam 分子名称: Beta-lactamase, GLYCEROL, PHOSPHATE ION, ... 著者 Chikunova, A, Bruenle, S, Ubbink, M. 登録日 2022-12-02 公開日 2023-07-05 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Asp179 in the class A beta-lactamase from Mycobacterium tuberculosis is a conserved yet not essential residue due to epistasis. Febs J., 290, 2023

<19202122232425262728293031323334>