4WYD

Adenosylmethionine-8-amino-7-oxononanoate aminotransferase from Mycobacterium tuberculosis complexed with a fragment from DSF screening

Summary for 4WYD

Entry DOI	10.2210/pdb4wyd/pdb
Related	4WYA 4WYC 4WYE 4WYF 4WYG
Descriptor	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase, PYRIDOXAL-5'-PHOSPHATE, N-methyl-1-[4-(1H-pyrazol-1-ylmethyl)phenyl]methanamine, ... (6 entities in total)
Functional Keywords	transaminase plp complex fragment, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Cellular location	Cytoplasm : P9WQ81
Total number of polymer chains	2
Total formula weight	99129.22
Authors	Dai, R.,Finzel, B.C.,Geders, T.W. (deposition date: 2014-11-17, release date: 2015-07-15, Last modification date: 2023-09-27)
Primary citation	Dai, R.,Geders, T.W.,Liu, F.,Park, S.W.,Schnappinger, D.,Aldrich, C.C.,Finzel, B.C. Fragment-Based Exploration of Binding Site Flexibility in Mycobacterium tuberculosis BioA. J.Med.Chem., 58:5208-5217, 2015 Cited by PubMed: 26068403 DOI: 10.1021/acs.jmedchem.5b00092 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.35 Å)

Structure validation