PDB: 13488 件ウェブページステータス検索Chemie searchBIRD

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7ZZO	HDAC2 in complex with an inhibitor 分子名称: 2-(cyclohexylazaniumyl)ethanesulfonate, CALCIUM ION, DI(HYDROXYETHYL)ETHER, ... 著者 Cleasby, A, Tisi, D. 登録日 2022-05-25 公開日 2022-09-21 最終更新日 2024-06-19 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Fragment-Based Discovery of a Novel, Brain Penetrant, Orally Active HDAC2 Inhibitor. Acs Med.Chem.Lett., 13, 2022
7ZZT	Ligand binding to HDAC2 分子名称: 1,2-ETHANEDIOL, 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, CALCIUM ION, ... 著者 Cleasby, A, Tisi, D. 登録日 2022-05-26 公開日 2022-09-21 最終更新日 2024-06-19 実験手法 X-RAY DIFFRACTION (1.56 Å) 主引用文献 Fragment-Based Discovery of a Novel, Brain Penetrant, Orally Active HDAC2 Inhibitor. Acs Med.Chem.Lett., 13, 2022
7ZZP	Structure of HDAC2 complexed with an inhibitory ligand 分子名称: (2S)-2-HYDROXYPROPANOIC ACID, 1,2-ETHANEDIOL, 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, ... 著者 Cleasby, A, Tisi, D. 登録日 2022-05-25 公開日 2022-09-21 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.52 Å) 主引用文献 Fragment-Based Discovery of a Novel, Brain Penetrant, Orally Active HDAC2 Inhibitor. Acs Med.Chem.Lett., 13, 2022
7ZZR	HDAC2 in complex with inhibitory ligand 分子名称: 1,2-ETHANEDIOL, 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, CALCIUM ION, ... 著者 Cleasby, A, Tisi, D. 登録日 2022-05-26 公開日 2022-09-21 最終更新日 2024-06-19 実験手法 X-RAY DIFFRACTION (2.168 Å) 主引用文献 Fragment-Based Discovery of a Novel, Brain Penetrant, Orally Active HDAC2 Inhibitor. Acs Med.Chem.Lett., 13, 2022
7ZZW	Ligand binding to HDAC2 分子名称: 1,2-ETHANEDIOL, 2-(cyclohexylazaniumyl)ethanesulfonate, CALCIUM ION, ... 著者 Cleasby, A, Tisi, D. 登録日 2022-05-26 公開日 2022-09-21 最終更新日 2024-06-19 実験手法 X-RAY DIFFRACTION (1.73 Å) 主引用文献 Fragment-Based Discovery of a Novel, Brain Penetrant, Orally Active HDAC2 Inhibitor. Acs Med.Chem.Lett., 13, 2022
7ZZS	HDAC2 complexed with an inhibitory ligand 分子名称: (5~{S})-5-(4-chlorophenyl)pyrrolidin-2-one, 1,2-ETHANEDIOL, 2-(cyclohexylazaniumyl)ethanesulfonate, ... 著者 Cleasby, A, Tisi, D. 登録日 2022-05-26 公開日 2022-09-21 最終更新日 2024-06-19 実験手法 X-RAY DIFFRACTION (1.88 Å) 主引用文献 Fragment-Based Discovery of a Novel, Brain Penetrant, Orally Active HDAC2 Inhibitor. Acs Med.Chem.Lett., 13, 2022
8A0B	Inhibitor binding to HDAC2 分子名称: 1,2-ETHANEDIOL, 1,3-dihydroisoindol-2-yl-[(2R,4S)-4-phenylpyrrolidin-1-ium-2-yl]methanone, 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, ... 著者 Cleasby, A, Tisi, D. 登録日 2022-05-27 公開日 2022-09-21 最終更新日 2024-06-19 実験手法 X-RAY DIFFRACTION (1.746 Å) 主引用文献 Fragment-Based Discovery of a Novel, Brain Penetrant, Orally Active HDAC2 Inhibitor. Acs Med.Chem.Lett., 13, 2022
7ZZU	Inhibitory Ligand binding to HDAC2 分子名称: 1,2-ETHANEDIOL, 2-[4-[(2~{R},4~{S})-4-phenylpyrrolidin-2-yl]carbonylpiperazin-1-yl]pyridine-3-carbonitrile, 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, ... 著者 Cleasby, A, Tisi, D. 登録日 2022-05-26 公開日 2022-09-21 最終更新日 2024-06-19 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Fragment-Based Discovery of a Novel, Brain Penetrant, Orally Active HDAC2 Inhibitor. Acs Med.Chem.Lett., 13, 2022
5M2N	Crystal Structure of Elongator subunit Elp2 分子名称: Elongator complex protein 2 著者 Glatt, S, Mueller, C.W. 登録日 2016-10-13 公開日 2016-12-28 最終更新日 2017-09-06 実験手法 X-RAY DIFFRACTION (2.812 Å) 主引用文献 Architecture of the yeast Elongator complex. EMBO Rep., 18, 2017
5BO4	Structure of SOCS2:Elongin C:Elongin B from DMSO-treated crystals 分子名称: Suppressor of cytokine signaling 2, Transcription elongation factor B polypeptide 1, Transcription elongation factor B polypeptide 2 著者 Gadd, M.S, Bulatov, E, Ciulli, A. 登録日 2015-05-27 公開日 2015-07-08 最終更新日 2024-10-09 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Serendipitous SAD Solution for DMSO-Soaked SOCS2-ElonginC-ElonginB Crystals Using Covalently Incorporated Dimethylarsenic: Insights into Substrate Receptor Conformational Flexibility in Cullin RING Ligases. Plos One, 10, 2015
5FVD	Human metapneumovirus N0-P complex 分子名称: CHLORIDE ION, NUCLEOCAPSID, PHOSPHOPROTEIN 著者 Renner, M, Bertinelli, M, Leyrat, C, Paesen, G.C, Saraiva de Oliveira, L.F, Huiskonen, J.T, Grimes, J.M. 登録日 2016-02-05 公開日 2016-02-24 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.86 Å) 主引用文献 Nucleocapsid assembly in pneumoviruses is regulated by conformational switching of the N protein. Elife, 5, 2016
8BOT	Cryo-EM structure of NHEJ supercomplex(trimer) 分子名称: DNA (24-MER), DNA (27-MER), DNA (28-MER), ... 著者 Hardwick, S.W, Chaplin, A.K. 登録日 2022-11-15 公開日 2023-06-28 最終更新日 2023-08-16 実験手法 ELECTRON MICROSCOPY (7.76 Å) 主引用文献 Cryo-EM structure of a DNA-PK trimer: higher order oligomerisation in NHEJ. Structure, 31, 2023
7YI3	Cryo-EM structure of Rpd3S in close-state Rpd3S-NCP complex 分子名称: Chromatin modification-related protein EAF3, Histone deacetylase RPD3, Transcriptional regulatory protein RCO1, ... 著者 Li, H.T, Yan, C.Y, Guan, H.P, Wang, P. 登録日 2022-07-14 公開日 2023-06-14 最終更新日 2023-08-30 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Diverse modes of H3K36me3-guided nucleosomal deacetylation by Rpd3S. Nature, 620, 2023
7YI2	Cryo-EM structure of Rpd3S in loose-state Rpd3S-NCP complex 分子名称: Chromatin modification-related protein EAF3, Histone deacetylase RPD3, Transcriptional regulatory protein RCO1, ... 著者 Li, H.T, Yan, C.Y, Guan, H.P, Wang, P. 登録日 2022-07-14 公開日 2023-06-14 最終更新日 2023-08-30 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 Diverse modes of H3K36me3-guided nucleosomal deacetylation by Rpd3S. Nature, 620, 2023
7YI0	Cryo-EM structure of Rpd3S complex 分子名称: Chromatin modification-related protein EAF3, Histone deacetylase RPD3, Transcriptional regulatory protein RCO1, ... 著者 Li, H.T, Yan, C.Y, Guan, H.P, Wang, P. 登録日 2022-07-14 公開日 2023-06-14 最終更新日 2023-08-30 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Diverse modes of H3K36me3-guided nucleosomal deacetylation by Rpd3S. Nature, 620, 2023
8FVI	Human APOBEC3H bound to HIV-1 Vif in complex with CBF-beta, ELOB, ELOC, and CUL5 分子名称: Core-binding factor subunit beta, Cullin 5, DNA dC->dU-editing enzyme APOBEC-3H, ... 著者 Ito, F, Alvarez-Cabrera, A.L, Zhou, Z.H, Chen, X.S. 登録日 2023-01-19 公開日 2023-09-06 最終更新日 2024-05-01 実験手法 ELECTRON MICROSCOPY (3.24 Å) 主引用文献 Structural basis of HIV-1 Vif-mediated E3 ligase targeting of host APOBEC3H. Nat Commun, 14, 2023
2C9W	CRYSTAL STRUCTURE OF SOCS-2 IN COMPLEX WITH ELONGIN-B AND ELONGIN-C AT 1.9A RESOLUTION 分子名称: NICKEL (II) ION, SULFATE ION, SUPPRESSOR OF CYTOKINE SIGNALING 2, ... 著者 Debreczeni, J.E, Bullock, A, Amos, A, Savitsky, P, Barr, A, Burgess, N, Sundstrom, M, Weigelt, J, Arrowsmith, C, Edwards, A, Knapp, S. 登録日 2005-12-14 公開日 2006-02-22 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Crystal structure of the SOCS2-elongin C-elongin B complex defines a prototypical SOCS box ubiquitin ligase. Proc. Natl. Acad. Sci. U.S.A., 103, 2006
8YF5	Cryo EM structure of Komagataella phaffii Rat1-Rai1-Rtt103 complex 分子名称: 5'-3' exoribonuclease, Decapping nuclease, Exonuclease Rat1p and Rai1p interacting protein 著者 Yanagisawa, T, Murayama, Y, Ehara, H, Sekine, S.I. 登録日 2024-02-24 公開日 2024-09-25 実験手法 ELECTRON MICROSCOPY (3.78 Å) 主引用文献 Structural basis of eukaryotic transcription termination by the Rat1 exonuclease complex. Nat Commun, 15, 2024
8YFE	Cryo EM structure of Komagataella phaffii Rat1-Rai1 complex 分子名称: 5'-3' exoribonuclease, Decapping nuclease 著者 Yanagisawa, T, Murayama, Y, Ehara, H, Sekine, S.I. 登録日 2024-02-24 公開日 2024-09-25 実験手法 ELECTRON MICROSCOPY (3.47 Å) 主引用文献 Structural basis of eukaryotic transcription termination by the Rat1 exonuclease complex. Nat Commun, 15, 2024
5E24	Structure of the Su(H)-Hairless-DNA Repressor Complex 分子名称: 1,2-ETHANEDIOL, DNA (5'-D(*AP*AP*TP*CP*TP*TP*TP*CP*CP*CP*AP*CP*AP*GP*T)-3'), DNA (5'-D(*TP*TP*AP*CP*TP*GP*TP*GP*GP*GP*AP*AP*AP*GP*A)-3'), ... 著者 Kovall, R.A, Yuan, Z. 登録日 2015-09-30 公開日 2016-06-15 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.14 Å) 主引用文献 Structure and Function of the Su(H)-Hairless Repressor Complex, the Major Antagonist of Notch Signaling in Drosophila melanogaster. Plos Biol., 14, 2016
7LRM	Structure of HIV-1 Reverse Transcriptase in complex with DNA, dCTP, and CA(2+) ion 分子名称: 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, CALCIUM ION, DNA/RNA (38-MER), ... 著者 Hoang, A, Ruiz, F.X, Arnold, E. 登録日 2021-02-16 公開日 2022-02-23 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (3.14 Å) 主引用文献 Structural basis of HIV inhibition by L-nucleosides: Opportunities for drug development and repurposing. Drug Discov Today, 27, 2022
7LRY	Structure of HIV-1 Reverse Transcriptase in complex with DNA, (-)FTC-TP, and CA(2+) ion 分子名称: AMMONIUM ION, CALCIUM ION, DNA/RNA (38-MER), ... 著者 Hoang, A, Ruiz, F.X, Arnold, E. 登録日 2021-02-17 公開日 2022-02-23 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.45 Å) 主引用文献 Structural basis of HIV inhibition by L-nucleosides: Opportunities for drug development and repurposing. Drug Discov Today, 27, 2022
7LSK	Structure of HIV-1 Reverse Transcriptase in complex with DNA, L-dTTP, and CA(2+) ion 分子名称: 1-{2-deoxy-5-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]oxy}phosphoryl]-beta-L-erythro-pentofuranosyl}-5-methylpyrimidine-2,4(1H,3H)-dione, AMMONIUM ION, CALCIUM ION, ... 著者 Hoang, A, Ruiz, F.X, Arnold, E. 登録日 2021-02-18 公開日 2022-02-23 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Structural basis of HIV inhibition by L-nucleosides: Opportunities for drug development and repurposing. Drug Discov Today, 27, 2022
7LRI	Structure of HIV-1 Reverse Transcriptase in complex with DNA, dTTP, and CA(2+) ion 分子名称: CALCIUM ION, DNA/RNA (38-MER), GLYCEROL, ... 著者 Hoang, A, Ruiz, F.X, Arnold, E. 登録日 2021-02-16 公開日 2022-02-23 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (3.05 Å) 主引用文献 Structural basis of HIV inhibition by L-nucleosides: Opportunities for drug development and repurposing. Drug Discov Today, 27, 2022
7LRX	Structure of HIV-1 Reverse Transcriptase in complex with DNA, L-dCTP, and CA(2+) ion 分子名称: 4-amino-1-{2-deoxy-5-O-[(R)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]oxy}phosphoryl]-beta-L-erythro-pentofuranosyl}pyrimidin-2(1H)-one, AMMONIUM ION, CALCIUM ION, ... 著者 Hoang, A, Ruiz, F.X, Arnold, E. 登録日 2021-02-17 公開日 2022-02-23 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Structural basis of HIV inhibition by L-nucleosides: Opportunities for drug development and repurposing. Drug Discov Today, 27, 2022

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