7LSK

Structure of HIV-1 Reverse Transcriptase in complex with DNA, L-dTTP, and CA(2+) ion

Summary for 7LSK

• Entry DOI: 10.2210/pdb7lsk/pdb
• Descriptor: Reverse transcriptase p66, Reverse transcriptase p51, DNA/RNA (38-MER), ... (10 entities in total)
• Functional Keywords: human immunodeficiency virus 1, protein/dsdna, aptamer, dntp, transferase, transferase-dna complex, transferase/dna
• Biological source: Human immunodeficiency virus type 1 (HIV-1); More
• Total number of polymer chains: 6
• Total formula weight: 253671.97

Authors

Hoang, A.,Ruiz, F.X.,Arnold, E. (deposition date: 2021-02-18, release date: 2022-02-23, Last modification date: 2023-10-18)

• Primary citation: Ruiz, F.X.,Hoang, A.,Dilmore, C.R.,DeStefano, J.J.,Arnold, E.; Structural basis of HIV inhibition by L-nucleosides: Opportunities for drug development and repurposing.; Drug Discov Today, 27:1832-1846, 2022; PubMed: 35218925; DOI: 10.1016/j.drudis.2022.02.016

Experimental method

X-RAY DIFFRACTION (2.7 Å)