PDB: 1328 件ウェブページステータス検索Chemie searchBIRD

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4RSG	Neutron crystal structure of Ras bound to the GTP analogue GppNHp 分子名称: GTPase HRas, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER 著者 Knihtila, R.R, Holzapfel, G, Weiss, K.L, Meilleur, F, Mattos, C. 登録日 2014-11-07 公開日 2015-11-04 最終更新日 2024-02-28 実験手法 NEUTRON DIFFRACTION (1.907 Å) 主引用文献 Neutron Crystal Structure of RAS GTPase Puts in Question the Protonation State of the GTP gamma-Phosphate. J.Biol.Chem., 290, 2015
5FR1	Double acetylated RhoGDI-alpha in complex with RhoA-GDP 分子名称: GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, RHO GDP-DISSOCIATION INHIBITOR 1, ... 著者 Kuhlmann, N, Wroblowski, S, Lammers, M. 登録日 2015-12-15 公開日 2016-01-13 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.75 Å) 主引用文献 Rhogdi Alpha Acetylation at K127 and K141 Affects Binding Towards Non-Prenylated Rhoa. Biochemistry, 55, 2016
5FR2	Farnesylated RhoA-GDP in complex with RhoGDI-alpha, lysine acetylated at K178 分子名称: FARNESYL, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... 著者 Kuhlmann, N, Wroblowski, S, Knyphausen, P, de Boor, S, Brenig, J, Zienert, A.Y, Meyer-Teschendorf, K, Praefcke, G.J.K, Nolte, H, Krueger, M, Schacherl, M, Baumann, U, James, L.C, Chin, J.W, Lammers, M. 登録日 2015-12-15 公開日 2016-01-13 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (3.35 Å) 主引用文献 Structural and Mechanistic Insights Into the Regulation of the Fundamental Rho-Regulator Rhogdi Alpha by Lysine Acetylation. J.Biol.Chem., 291, 2016
5CM8	Structural Basis for the Selectivity of Guanine Nucleotide Exchange Factors for the small G-protein Ral 分子名称: Ral guanine nucleotide dissociation stimulator-like 2, Ras-related protein Ral-a 著者 Popovic, M, Schouten, A, Rehmann, H. 登録日 2015-07-16 公開日 2016-01-13 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 The structure of the Guanine Nucleotide Exchange Factor Rlf in complex with the small G-protein Ral identifies conformational intermediates of the exchange reaction and the basis for the selectivity. J.Struct.Biol., 193, 2016
5CM9	Structural Basis for the Selectivity of Guanine Nucleotide Exchange Factors for the small G-protein Ral 分子名称: Ral guanine nucleotide dissociation stimulator-like 2, Ras-related protein Ral-a 著者 Popovic, M, Schouten, A, Rehmann, H. 登録日 2015-07-16 公開日 2016-01-13 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 The structure of the Guanine Nucleotide Exchange Factor Rlf in complex with the small G-protein Ral identifies conformational intermediates of the exchange reaction and the basis for the selectivity. J.Struct.Biol., 193, 2016
5F2E	Crystal Structure of small molecule ARS-853 covalently bound to K-Ras G12C 分子名称: 1-[3-[4-[2-[[4-chloranyl-5-(1-methylcyclopropyl)-2-oxidanyl-phenyl]amino]ethanoyl]piperazin-1-yl]azetidin-1-yl]prop-2-en-1-one, GLYCEROL, GLYCINE, ... 著者 Patricelli, M.P, Janes, M.R, Li, L.-S, Hansen, R, Peters, U, Kessler, L.V, Chen, Y, Kucharski, J.M, Feng, J, Ely, T, Chen, J.H, Firdaus, S.J, Babbar, A, Ren, P, Liu, Y. 登録日 2015-12-01 公開日 2016-01-13 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Selective Inhibition of Oncogenic KRAS Output with Small Molecules Targeting the Inactive State. Cancer Discov, 6, 2016
5C46	Crystal structure of an engineered construct of phosphatidylinositol 4 kinase III beta in complex with GTP gamma S loaded Rab11 分子名称: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, MAGNESIUM ION, Phosphatidylinositol 4-kinase beta, ... 著者 Burke, J.E, Fowler, M.L. 登録日 2015-06-17 公開日 2016-01-20 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.65 Å) 主引用文献 Using hydrogen deuterium exchange mass spectrometry to engineer optimized constructs for crystallization of protein complexes: Case study of PI4KIII beta with Rab11. Protein Sci., 25, 2016
5C4G	Crystal structure of an engineered construct of phosphatidylinositol 4 kinase III beta with the inhibitor BQR695 in complex with GDP loaded Rab11 分子名称: GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, N~2~-[7-(3,4-dimethoxyphenyl)quinoxalin-2-yl]-N-methylglycinamide, ... 著者 Burke, J.E, Fowler, M.L. 登録日 2015-06-18 公開日 2016-01-20 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Using hydrogen deuterium exchange mass spectrometry to engineer optimized constructs for crystallization of protein complexes: Case study of PI4KIII beta with Rab11. Protein Sci., 25, 2016
5EUQ	Crystal structure of an engineered construct of phosphatidylinositol 4 kinase III beta with a potent and selective inhibitor in complex with GDP loaded Rab11 分子名称: GUANOSINE-5'-DIPHOSPHATE, Phosphatidylinositol 4-kinase beta, Ras-related protein Rab-11A, ... 著者 Burke, J.E, Fowler, M.L. 登録日 2015-11-19 公開日 2016-02-24 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Design and Structural Characterization of Potent and Selective Inhibitors of Phosphatidylinositol 4 Kinase III beta. J.Med.Chem., 59, 2016
5FI1	Crystal Structure of the P-Rex1 DH/PH tandem in complex with Cdc42 分子名称: Cell division control protein 42 homolog, Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein,Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein 著者 Cash, J.N, Tesmer, J.J.G. 登録日 2015-12-22 公開日 2016-04-20 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (3.203 Å) 主引用文献 Structural and Biochemical Characterization of the Catalytic Core of the Metastatic Factor P-Rex1 and Its Regulation by PtdIns(3,4,5)P3. Structure, 24, 2016
2N1B	NMR solution structure of nucleotide-free Ran GTPase 分子名称: GTP-binding nuclear protein Ran 著者 Bacot-Davis, V.R, Palmenberg, A.C. 登録日 2015-03-26 公開日 2016-04-20 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 NMR Structure of Ran GTPase Determines C-terminal Tail Conformational Dynamics. To be Published
5FI0	Crystal Structure of the P-Rex1 DH/PH tandem in complex with Rac1 分子名称: PHOSPHATE ION, Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein,Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein, Ras-related C3 botulinum toxin substrate 1 著者 Cash, J.N, Tesmer, J.J.G. 登録日 2015-12-22 公開日 2016-04-20 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (3.282 Å) 主引用文献 Structural and Biochemical Characterization of the Catalytic Core of the Metastatic Factor P-Rex1 and Its Regulation by PtdIns(3,4,5)P3. Structure, 24, 2016
5C1S	Crystal structure of the GDP-bound fast hydrolyzing mutant (V71A/K73Q) of EhRabX3 from Entamoeba histolytica 分子名称: GUANOSINE-5'-DIPHOSPHATE, Small GTPase EhRabX3 著者 Srivastava, V.K, Chandra, M, Datta, S. 登録日 2015-06-15 公開日 2016-04-27 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Crystal Structure Analysis of Wild Type and Fast Hydrolyzing Mutant of EhRabX3, a Tandem Ras Superfamily GTPase from Entamoeba histolytica. J.Mol.Biol., 428, 2016
5C1T	Crystal structure of the GTP-bound wild type EhRabX3 from Entamoeba histolytica 分子名称: GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Small GTPase EhRabX3 著者 Srivastava, V.K, Chandra, M, Datta, S. 登録日 2015-06-15 公開日 2016-04-27 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.801 Å) 主引用文献 Crystal Structure Analysis of Wild Type and Fast Hydrolyzing Mutant of EhRabX3, a Tandem Ras Superfamily GTPase from Entamoeba histolytica. J.Mol.Biol., 428, 2016
5B30	H-Ras WT in complex with GppNHp (state 1) after structural transition by humidity control 分子名称: CALCIUM ION, GTPase HRas, MAGNESIUM ION, ... 著者 Kumasaka, T, Miyano, N, Baba, S, Matsumoto, S, Kataoka, T, Shima, F. 登録日 2016-02-08 公開日 2016-06-01 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Molecular Mechanism for Conformational Dynamics of Ras-GTP Elucidated from In-Situ Structural Transition in Crystal Sci Rep, 6, 2016
5B2Z	H-Ras WT in complex with GppNHp (state 2*) before structural transition by humidity control 分子名称: CALCIUM ION, GTPase HRas, MAGNESIUM ION, ... 著者 Kumasaka, T, Miyano, N, Baba, S, Matsumoto, S, Kataoka, T, Shima, F. 登録日 2016-02-07 公開日 2016-06-01 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.56 Å) 主引用文献 Molecular Mechanism for Conformational Dynamics of Ras-GTP Elucidated from In-Situ Structural Transition in Crystal Sci Rep, 6, 2016
5C2J	Complex structure of the GAP domain of MgcRacGAP and Cdc42 分子名称: ALUMINUM FLUORIDE, Cell division control protein 42 homolog, GUANOSINE-5'-DIPHOSPHATE, ... 著者 Murayama, K, Kato-Murayama, M, Hosaka, T, Kitamura, T, Yokoyama, S, Shirouzu, M. 登録日 2015-06-16 公開日 2016-06-22 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structural basis of G-protein target alternation of MgcRacGAP by phospholylation To Be Published
5C2K	Crystal structure of the fusion protein linked by RhoA and the GAP domain of MgcRacGAP 分子名称: ALUMINUM FLUORIDE, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... 著者 Murayama, K, Kato-Murayama, M, Hosaka, T, Kitamura, T, Yokoyama, S, Shirouzu, M. 登録日 2015-06-16 公開日 2016-06-22 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.42 Å) 主引用文献 Structural basis of G-protein target alternation of MgcRacGAP by phospholylation To Be Published
5DLQ	Crystal structure of RanGTP-Exportin 4-eIF5A complex 分子名称: Eukaryotic translation initiation factor 5A-1, Exportin-4, GTP-binding nuclear protein Ran, ... 著者 Aksu, M, Trakhanov, S, Gorlich, D. 登録日 2015-09-07 公開日 2016-06-22 最終更新日 2016-06-29 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Structure of the exportin Xpo4 in complex with RanGTP and the hypusine-containing translation factor eIF5A. Nat Commun, 7, 2016
5JCP	RhoGAP domain of ARAP3 in complex with RhoA in the transition state 分子名称: Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3,Linker,Transforming protein RhoA, GUANOSINE-5'-DIPHOSPHATE, ... 著者 Bao, H, Li, F, Wang, C, Wang, N, Jiang, Y, Tang, Y, Wu, J, Shi, Y. 登録日 2016-04-15 公開日 2016-06-22 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structural Basis for the Specific Recognition of RhoA by the Dual GTPase-activating Protein ARAP3 J.Biol.Chem., 291, 2016
5JLJ	Crystal Structure of KPT8602 in complex with CRM1-Ran-RanBP1 分子名称: (2R)-3-{3-[3,5-bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl}-2-(pyrimidin-5-yl)propanamide, CHLORIDE ION, Exportin-1, ... 著者 Fung, H.Y, Chook, Y.M. 登録日 2016-04-27 公開日 2016-06-29 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Next-generation XPO1 inhibitor shows improved efficacy and in vivo tolerability in hematological malignancies. Leukemia, 30, 2016
5C4M	RhoA GDP with novel switch II conformation 分子名称: GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Transforming protein RhoA 著者 Pellegrini, E, Bowler, M.W. 登録日 2015-06-18 公開日 2016-06-29 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.3 Å) 主引用文献 RhoA GDP with novel switch II conformation To Be Published
5HPY	Crystal Structure of RhoA.GDP.MgF3-in complex with human Myosin 9b RhoGAP domain 分子名称: GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, TRIFLUOROMAGNESATE, ... 著者 Yi, F.S, Ren, J.Q, Feng, W. 登録日 2016-01-21 公開日 2016-07-13 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Noncanonical Myo9b-RhoGAP Accelerates RhoA GTP Hydrolysis by a Dual-Arginine-Finger Mechanism J.Mol.Biol., 428, 2016
5CJP	The Structural Basis for Cdc42-Induced Dimerization of IQGAPs 分子名称: Cell division cycle 42 (GTP binding protein, 25kDa), isoform CRA_a, ... 著者 Worthylake, D.K, Boyapati, V.K, LeCour Jr, L. 登録日 2015-07-14 公開日 2016-08-10 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 The Structural Basis for Cdc42-Induced Dimerization of IQGAPs. Structure, 24, 2016
5IRC	p190A GAP domain complex with RhoA 分子名称: CHLORIDE ION, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... 著者 Derewenda, U, Derewenda, Z. 登録日 2016-03-12 公開日 2016-08-17 最終更新日 2019-12-25 実験手法 X-RAY DIFFRACTION (1.72 Å) 主引用文献 Deciphering the Molecular and Functional Basis of RHOGAP Family Proteins: A SYSTEMATIC APPROACH TOWARD SELECTIVE INACTIVATION OF RHO FAMILY PROTEINS. J.Biol.Chem., 291, 2016

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