PDB: 17012 件ウェブページステータス検索Chemie searchBIRD

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1QYW	Crystal structure of human estrogenic 17beta-hydroxysteroid dehydrogenase complex with androstanedione and NADP 分子名称: 5ALPHA-ANDROSTAN-3,17-DIONE, Estradiol 17 beta-dehydrogenase 1, GLYCEROL, ... 著者 Shi, R, Lin, S.X. 登録日 2003-09-12 公開日 2004-08-03 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (1.63 Å) 主引用文献 Cofactor hydrogen bonding onto the protein main chain is conserved in the short chain dehydrogenase/reductase family and contributes to nicotinamide orientation. J.Biol.Chem., 279, 2004
2HD9	Crystal structure of PH1033 from Pyrococcus horikoshii OT3 分子名称: CALCIUM ION, CITRIC ACID, GLYCEROL, ... 著者 Sugahara, M, Kunishima, N, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2006-06-20 公開日 2006-12-20 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.35 Å) 主引用文献 Nucleant-mediated protein crystallization with the application of microporous synthetic zeolites. Acta Crystallogr.,Sect.D, 64, 2008
2HH0	Structure of an Anti-PrP Fab, P-Clone, in Complex with its Cognate Bovine Peptide Epitope. 分子名称: Heavy Chain, P-Clone Fab, Chimera, ... 著者 Kanyo, Z.K. 登録日 2006-06-27 公開日 2006-12-26 最終更新日 2017-10-11 実験手法 X-RAY DIFFRACTION (2.85 Å) 主引用文献 Directed evolution of an anti-prion protein scFv fragment to an affinity of 1 pM and its structural interpretation J.Mol.Biol., 363, 2006
2JRK	NMR Structure and Epitope Mapping of Blo t 5 分子名称: Mite allergen Blo t 5 著者 Chan, S, Mok, Y. 登録日 2007-06-27 公開日 2008-07-01 最終更新日 2024-05-01 実験手法 SOLUTION NMR 主引用文献 Nuclear magnetic resonance structure and IgE epitopes of Blo t 5, a major dust mite allergen J.Immunol., 181, 2008
5A1U	The structure of the COPI coat triad 分子名称: ADP-RIBOSYLATION FACTOR 1, COATOMER SUBUNIT ALPHA, COATOMER SUBUNIT BETA, ... 著者 Dodonova, S.O, Diestelkoetter-Bachert, P, von Appen, A, Hagen, W.J.H, Beck, R, Beck, M, Wieland, F, Briggs, J.A.G. 登録日 2015-05-06 公開日 2015-07-08 最終更新日 2024-05-08 実験手法 ELECTRON MICROSCOPY (13 Å) 主引用文献 Vesicular Transport. A Structure of the Copi Coat and the Role of Coat Proteins in Membrane Vesicle Assembly. Science, 349, 2015
5A1Y	The structure of the COPI coat linkage IV 分子名称: ADP-RIBOSYLATION FACTOR 1, COATOMER SUBUNIT ALPHA, COATOMER SUBUNIT BETA, ... 著者 Dodonova, S.O, Diestelkoetter-Bachert, P, von Appen, A, Hagen, W.J.H, Beck, R, Beck, M, Wieland, F, Briggs, J.A.G. 登録日 2015-05-06 公開日 2015-07-08 最終更新日 2024-05-08 実験手法 ELECTRON MICROSCOPY (21 Å) 主引用文献 Vesicular Transport. A Structure of the Copi Coat and the Role of Coat Proteins in Membrane Vesicle Assembly. Science, 349, 2015
5A0Q	Cryo-EM reveals the conformation of a substrate analogue in the human 20S proteasome core 分子名称: ADA-(AHX)3-(LEU)3-VINYL SULFONE, PROTEASOME SUBUNIT ALPHA TYPE-1, PROTEASOME SUBUNIT ALPHA TYPE-2, ... 著者 daFonseca, P.C.A, Morris, E.P. 登録日 2015-04-22 公開日 2015-12-30 最終更新日 2017-08-02 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 Cryo-Em Reveals the Conformation of a Substrate Analogue in the Human 20S Proteasome Core. Nat.Commun., 6, 2015
5A1V	The structure of the COPI coat linkage I 分子名称: ADP-RIBOSYLATION FACTOR 1, COATOMER SUBUNIT ALPHA, COATOMER SUBUNIT BETA, ... 著者 Dodonova, S.O, Diestelkoetter-Bachert, P, von Appen, A, Hagen, W.J.H, Beck, R, Beck, M, Wieland, F, Briggs, J.A.G. 登録日 2015-05-06 公開日 2015-07-08 最終更新日 2024-05-08 実験手法 ELECTRON MICROSCOPY (21 Å) 主引用文献 Vesicular Transport. A Structure of the Copi Coat and the Role of Coat Proteins in Membrane Vesicle Assembly. Science, 349, 2015
5A1W	The structure of the COPI coat linkage II 分子名称: ADP-RIBOSYLATION FACTOR 1, COATOMER SUBUNIT ALPHA, COATOMER SUBUNIT BETA, ... 著者 Dodonova, S.O, Diestelkoetter-Bachert, P, von Appen, A, Hagen, W.J.H, Beck, R, Beck, M, Wieland, F, Briggs, J.A.G. 登録日 2015-05-06 公開日 2015-07-08 最終更新日 2024-05-08 実験手法 ELECTRON MICROSCOPY (18 Å) 主引用文献 Vesicular Transport. A Structure of the Copi Coat and the Role of Coat Proteins in Membrane Vesicle Assembly. Science, 349, 2015
5A1X	The structure of the COPI coat linkage III 分子名称: ADP-RIBOSYLATION FACTOR 1, COATOMER SUBUNIT ALPHA, COATOMER SUBUNIT BETA, ... 著者 Dodonova, S.O, Diestelkoetter-Bachert, P, von Appen, A, Hagen, W.J.H, Beck, R, Beck, M, Wieland, F, Briggs, J.A.G. 登録日 2015-05-06 公開日 2015-07-08 最終更新日 2024-05-08 実験手法 ELECTRON MICROSCOPY (23 Å) 主引用文献 Vesicular Transport. A Structure of the Copi Coat and the Role of Coat Proteins in Membrane Vesicle Assembly. Science, 349, 2015
6MNE	CRYSTAL STRUCTURE OF HUMAN 17BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 COMPLEXED WITH ESTRONE AND NADP+ 分子名称: (9beta,13alpha)-3-hydroxyestra-1,3,5(10)-trien-17-one, Estradiol 17-beta-dehydrogenase 1, GLYCEROL, ... 著者 Li, T, Lin, S.X. 登録日 2018-10-01 公開日 2019-04-03 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.86 Å) 主引用文献 Crystal structures of human 17 beta-hydroxysteroid dehydrogenase type 1 complexed with estrone and NADP+reveal the mechanism of substrate inhibition. Febs J., 286, 2019
6MNC	CRYSTAL STRUCTURE OF HUMAN 17BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 COMPLEXED WITH ESTRONE 分子名称: (9beta,13alpha)-3-hydroxyestra-1,3,5(10)-trien-17-one, DI(HYDROXYETHYL)ETHER, Estradiol 17-beta-dehydrogenase 1 著者 Li, T, Stephen, P, Zhu, D.W, Lin, S.X. 登録日 2018-10-01 公開日 2019-04-03 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Crystal structures of human 17 beta-hydroxysteroid dehydrogenase type 1 complexed with estrone and NADP+reveal the mechanism of substrate inhibition. Febs J., 286, 2019
6A7B	AKR1C3 complexed with new inhibitor with novel scaffold 分子名称: (4R)-6-amino-4-(4-hydroxy-3-methoxy-5-nitrophenyl)-3-propyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile, Aldo-keto reductase family 1 member C3, DIMETHYLFORMAMIDE, ... 著者 Zheng, X, Zhao, Y, Zhang, H, Chen, Y. 登録日 2018-07-02 公開日 2019-07-03 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.37 Å) 主引用文献 Screening, synthesis, crystal structure, and molecular basis of 6-amino-4-phenyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitriles as novel AKR1C3 inhibitors. Bioorg.Med.Chem., 26, 2018
6RS2	Structure of the Bateman module of human CNNM4. 分子名称: Metal transporter CNNM4 著者 Corral-Rodriguez, M.A, Stuiver, M, Gomez-Garcia, I, Oyenarte, I, Gimenez, P, Ereno-Orbea, J, Diercks, T, Muller, D, Martinez-Cruz, L.A. 登録日 2019-05-21 公開日 2020-07-15 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (3.694 Å) 主引用文献 Structural Insights into the Intracellular Region of the Human Magnesium Transport Mediator CNNM4. Int J Mol Sci, 20, 2019
7DMP	Mouse radial spoke complex 分子名称: Radial spoke head 1 homolog, Radial spoke head protein 4 homolog A, Radial spoke head protein 9 homolog 著者 Zheng, W, Cong, Y. 登録日 2020-12-05 公開日 2021-07-21 最終更新日 2024-03-27 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Distinct architecture and composition of mouse axonemal radial spoke head revealed by cryo-EM Proc.Natl.Acad.Sci.USA, 118, 2021
7CYM	Crystal structure of LI-Cadherin EC1-4 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... 著者 Caaveiro, J.M.M, Yui, A, Tsumoto, K. 登録日 2020-09-03 公開日 2021-08-18 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Mechanism of dimerization and structural features of human LI-cadherin. J.Biol.Chem., 297, 2021
7DRE	Cryo-EM structure of DfgA-B at 2.54 angstrom resolution 分子名称: DfgB, Sugar phosphate isomerase/epimerase 著者 Mori, T, Moriya, T, Adachi, N, Senda, T, Abe, I. 登録日 2020-12-28 公開日 2021-12-08 最終更新日 2024-06-05 実験手法 ELECTRON MICROSCOPY (2.54 Å) 主引用文献 C-Glycoside metabolism in the gut and in nature: Identification, characterization, structural analyses and distribution of C-C bond-cleaving enzymes. Nat Commun, 12, 2021
1FDS	HUMAN 17-BETA-HYDROXYSTEROID-DEHYDROGENASE TYPE 1 COMPLEXED WITH 17-BETA-ESTRADIOL 分子名称: 17-BETA-HYDROXYSTEROID-DEHYDROGENASE, ESTRADIOL 著者 Housset, D, Breton, R, Mazza, C, Fontecilla-Camps, J.-C. 登録日 1996-06-28 公開日 1997-02-12 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 The structure of a complex of human 17beta-hydroxysteroid dehydrogenase with estradiol and NADP+ identifies two principal targets for the design of inhibitors. Structure, 4, 1996
1FDV	HUMAN 17-BETA-HYDROXYSTEROID-DEHYDROGENASE TYPE 1 MUTANT H221L COMPLEXED WITH NAD+ 分子名称: 17-BETA-HYDROXYSTEROID DEHYDROGENASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, SULFATE ION 著者 Mazza, C, Breton, R, Housset, D, Fontecilla-Camps, J.-C. 登録日 1998-01-15 公開日 1998-05-27 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Unusual charge stabilization of NADP+ in 17beta-hydroxysteroid dehydrogenase. J.Biol.Chem., 273, 1998
1FDW	HUMAN 17-BETA-HYDROXYSTEROID-DEHYDROGENASE TYPE 1 MUTANT H221Q COMPLEXED WITH ESTRADIOL 分子名称: 17-BETA-HYDROXYSTEROID DEHYDROGENASE, ESTRADIOL 著者 Mazza, C, Breton, R, Housset, D, Fontecilla-Camps, J.-C. 登録日 1998-01-16 公開日 1998-05-27 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Unusual charge stabilization of NADP+ in 17beta-hydroxysteroid dehydrogenase. J.Biol.Chem., 273, 1998
1FDU	HUMAN 17-BETA-HYDROXYSTEROID-DEHYDROGENASE TYPE 1 MUTANT H221L COMPLEXED WITH ESTRADIOL AND NADP+ 分子名称: 17-BETA-HYDROXYSTEROID DEHYDROGENASE, ESTRADIOL, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... 著者 Mazza, C, Breton, R, Housset, D, Fontecilla-Camps, J.-C. 登録日 1998-01-14 公開日 1998-05-27 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Unusual charge stabilization of NADP+ in 17beta-hydroxysteroid dehydrogenase. J.Biol.Chem., 273, 1998
8ABR	Crystal structure of CYP109A2 from Bacillus megaterium bound with putative ligands hexanoic acid and octanoic acid 分子名称: Cytochrome P450, HEME B/C, HEXANOIC ACID, ... 著者 Jozwik, I.K, Rozeboom, H.J, Thunnissen, A.-M.W.H. 登録日 2022-07-04 公開日 2023-07-12 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Regio- and stereoselective steroid hydroxylation by CYP109A2 from Bacillus megaterium explored by X-ray crystallography and computational modeling. Febs J., 290, 2023
1FDT	HUMAN 17-BETA-HYDROXYSTEROID-DEHYDROGENASE TYPE 1 COMPLEXED WITH ESTRADIOL AND NADP+ 分子名称: 17-BETA-HYDROXYSTEROID-DEHYDROGENASE, ESTRADIOL, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... 著者 Housset, D, Breton, R, Mazza, C, Fontecilla-Camps, J.-C. 登録日 1996-06-28 公開日 1997-02-12 最終更新日 2024-06-05 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 The structure of a complex of human 17beta-hydroxysteroid dehydrogenase with estradiol and NADP+ identifies two principal targets for the design of inhibitors. Structure, 4, 1996
5NRS	Human DNMT3B PWWP domain in complex with N,N-bis(2-hydroxypropyl)ethanolamine 分子名称: (2~{S})-1-[2-hydroxyethyl-[(2~{S})-2-oxidanylpropyl]amino]propan-2-ol, DNA (cytosine-5)-methyltransferase 3B, SULFATE ION 著者 Rondelet, G, Wouters, J. 登録日 2017-04-25 公開日 2018-05-30 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Targeting PWWP domain of DNA methyltransferase 3B for epigenetic cancer therapy: Identification and structural characterization of new potential protein-protein interaction inhibitors To be published
5NRR	Human DNMT3B PWWP domain in complex with 5-[(2-Hydroxyethyl)(propyl)amino]-1-pentanol 分子名称: 5-[2-hydroxyethyl(propyl)amino]pentan-1-ol, DNA (cytosine-5)-methyltransferase 3B, SULFATE ION 著者 Rondelet, G, Wouters, J. 登録日 2017-04-25 公開日 2018-05-30 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Targeting PWWP domain of DNA methyltransferase 3B for epigenetic cancer therapy: Identification and structural characterization of new potential protein-protein interaction inhibitors To be published

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