5A0Q
Cryo-EM reveals the conformation of a substrate analogue in the human 20S proteasome core
Summary for 5A0Q
Entry DOI | 10.2210/pdb5a0q/pdb |
EMDB information | 2981 |
Descriptor | PROTEASOME SUBUNIT ALPHA TYPE-6, PROTEASOME SUBUNIT BETA TYPE-3, PROTEASOME SUBUNIT BETA TYPE-2, ... (15 entities in total) |
Functional Keywords | hydrolase, proteasome, 20s, adaahx3l3vs, ligand, inhibitor, drug design |
Biological source | HOMO SAPIENS (HUMAN) More |
Cellular location | Cytoplasm : P60900 P49720 P49721 P28074 P20618 P28070 P25787 P25789 O14818 P28066 P25786 P25788 P28072 Q99436 |
Total number of polymer chains | 28 |
Total formula weight | 723185.21 |
Authors | daFonseca, P.C.A.,Morris, E.P. (deposition date: 2015-04-22, release date: 2015-12-30, Last modification date: 2017-08-02) |
Primary citation | Da Fonseca, P.C.A.,Morris, E.P. Cryo-Em Reveals the Conformation of a Substrate Analogue in the Human 20S Proteasome Core. Nat.Commun., 6:7573-, 2015 Cited by PubMed: 26133119DOI: 10.1038/NCOMMS8573 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.5 Å) |
Structure validation
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