5A0Q
Cryo-EM reveals the conformation of a substrate analogue in the human 20S proteasome core
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, O (A, O) | PROTEASOME SUBUNIT ALPHA TYPE-6 | polymer | 246 | 27432.5 | 2 | UniProt (P60900) Pfam (PF10584) Pfam (PF00227) | HOMO SAPIENS (HUMAN) | 27 KDA PROSOMAL PROTEIN, P27K, MACROPAIN IOTA CHAIN, MULTICATALYTIC ENDOPEPTIDASE COMPLEX IOTA CHAIN, PROTEASOME IOTA CHAIN |
| 2 | B, P (B, P) | PROTEASOME SUBUNIT ALPHA TYPE-2 | polymer | 234 | 25927.5 | 2 | UniProt (P25787) Pfam (PF10584) Pfam (PF00227) | HOMO SAPIENS (HUMAN) | MACROPAIN SUBUNIT C3, MULTICATALYTIC ENDOPEPTIDASE COMPLEX SUBUNIT C3, PROTEASOME COMPONENT C3 |
| 3 | C, Q (C, Q) | PROTEASOME SUBUNIT ALPHA TYPE-4 | polymer | 261 | 29525.8 | 2 | UniProt (P25789) Pfam (PF10584) Pfam (PF00227) | HOMO SAPIENS (HUMAN) | MACROPAIN SUBUNIT C9, MULTICATALYTIC ENDOPEPTIDASE COMPLEX SUBUNIT C9, PROTEASOME COMPONENT C9, PROTEASOME SUBUNIT L |
| 4 | D, R (D, R) | PROTEASOME SUBUNIT ALPHA TYPE-7 | polymer | 248 | 27929.9 | 2 | UniProt (O14818) Pfam (PF10584) Pfam (PF00227) | HOMO SAPIENS (HUMAN) | PROTEASOME SUBUNIT RC6-1, PROTEASOME SUBUNIT XAPC7 |
| 5 | E, S (E, S) | PROTEASOME SUBUNIT ALPHA TYPE-5 | polymer | 241 | 26436.0 | 2 | UniProt (P28066) Pfam (PF00227) Pfam (PF10584) | HOMO SAPIENS (HUMAN) | MACROPAIN ZETA CHAIN, MULTICATALYTIC ENDOPEPTIDASE COMPLEX ZETA CHAIN, PROTEASOME ZETA CHAIN |
| 6 | F, T (F, T) | PROTEASOME SUBUNIT ALPHA TYPE-1 | polymer | 263 | 29595.6 | 2 | UniProt (P25786) Pfam (PF10584) Pfam (PF00227) | HOMO SAPIENS (HUMAN) | 30 KDA PROSOMAL PROTEIN, PROS-30, MACROPAIN SUBUNIT C2, MULTICATALYTIC ENDOPEPTIDASE COMPLEX SUBUNIT C2, PROTEASOME COMPONENT C2, PROTEASOME NU CHAIN |
| 7 | G, U (G, U) | PROTEASOME SUBUNIT ALPHA TYPE-3 | polymer | 255 | 28469.3 | 2 | UniProt (P25788) Pfam (PF10584) Pfam (PF00227) | HOMO SAPIENS (HUMAN) | MACROPAIN SUBUNIT C8, MULTICATALYTIC ENDOPEPTIDASE COMPLEX SUBUNIT C8, PROTEASOME COMPONENT C8 |
| 8 | H, V (H, V) | PROTEASOME SUBUNIT BETA TYPE-6 | polymer | 205 | 21921.8 | 2 | UniProt (P28072) Pfam (PF00227) | HOMO SAPIENS (HUMAN) | MACROPAIN DELTA CHAIN, MULTICATALYTIC ENDOPEPTIDASE COMPLEX DELTA CHAIN, PROTEASOME DELTA CHAIN, PROTEASOME SUBUNIT Y |
| 9 | I, W (I, W) | PROTEASOME SUBUNIT BETA TYPE-7 | polymer | 234 | 25322.0 | 2 | UniProt (Q99436) Pfam (PF00227) Pfam (PF12465) | HOMO SAPIENS (HUMAN) | MACROPAIN CHAIN Z, MULTICATALYTIC ENDOPEPTIDASE COMPLEX CHAIN Z, PROTEASOME SUBUNIT Z |
| 10 | J, X (J, X) | PROTEASOME SUBUNIT BETA TYPE-3 | polymer | 204 | 22841.7 | 2 | UniProt (P49720) Pfam (PF00227) | HOMO SAPIENS (HUMAN) | PROTEASOME CHAIN 13, PROTEASOME COMPONENT C10-II, PROTEASOME THETA CHAIN |
| 11 | K, Y (K, Y) | PROTEASOME SUBUNIT BETA TYPE-2 | polymer | 201 | 22864.3 | 2 | UniProt (P49721) Pfam (PF00227) | HOMO SAPIENS (HUMAN) | MACROPAIN SUBUNIT C7-I, MULTICATALYTIC ENDOPEPTIDASE COMPLEX SUBUNIT C7-I, PROTEASOME COMPONENT C7-I |
| 12 | L, Z (L, Z) | PROTEASOME SUBUNIT BETA TYPE-5 | polymer | 204 | 22484.4 | 2 | UniProt (P28074) Pfam (PF00227) | HOMO SAPIENS (HUMAN) | MACROPAIN EPSILON CHAIN, MULTICATALYTIC ENDOPEPTIDASE COMPLEX EPSILON CHAIN, PROTEASOME CHAIN 6, PROTEASOME EPSILON CHAIN, PROTEASOME SUBUNIT MB1, PROTEASOME SUBUNIT X |
| 13 | AA, M (M, a) | PROTEASOME SUBUNIT BETA TYPE-1 | polymer | 213 | 23579.0 | 2 | UniProt (P20618) Pfam (PF00227) | HOMO SAPIENS (HUMAN) | MACROPAIN SUBUNIT C5, MULTICATALYTIC ENDOPEPTIDASE COMPLEX SUBUNIT C5, PROTEASOME COMPONENT C5, PROTEASOME GAMMA CHAIN |
| 14 | BA, N (N, b) | PROTEASOME SUBUNIT BETA TYPE-4 | polymer | 219 | 24414.7 | 2 | UniProt (P28070) Pfam (PF00227) | HOMO SAPIENS (HUMAN) | 26 KDA PROSOMAL PROTEIN, PROS-26, MACROPAIN BETA CHAIN, MULTICATALYTIC ENDOPEPTIDASE COMPLEX BETA CHAIN, PROTEASOME BETA CHAIN, PROTEASOME CHAIN 3, HSN3 |
| 15 | CA, DA, EA, FA, GA... (H, I, L, V, W...) | ADA-(AHX)3-(LEU)3-VINYL SULFONE | non-polymer | 949.4 | 6 | Chemie (KNM) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 28 |
| Total formula weight | 717488.9 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 5696.3 | |
| All* | Total formula weight | 723185.2 |
