5A0Q

Cryo-EM reveals the conformation of a substrate analogue in the human 20S proteasome core

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, O	PROTEASOME SUBUNIT ALPHA TYPE-6	polymer	246	27432.5	2	UniProt (P60900) Pfam (PF10584) Pfam (PF00227) In PDB	HOMO SAPIENS (HUMAN)	27 KDA PROSOMAL PROTEIN, P27K, MACROPAIN IOTA CHAIN, MULTICATALYTIC ENDOPEPTIDASE COMPLEX IOTA CHAIN, PROTEASOME IOTA CHAIN
2	B, P	PROTEASOME SUBUNIT ALPHA TYPE-2	polymer	234	25927.5	2	UniProt (P25787) Pfam (PF10584) Pfam (PF00227) In PDB	HOMO SAPIENS (HUMAN)	MACROPAIN SUBUNIT C3, MULTICATALYTIC ENDOPEPTIDASE COMPLEX SUBUNIT C3, PROTEASOME COMPONENT C3
3	C, Q	PROTEASOME SUBUNIT ALPHA TYPE-4	polymer	261	29525.8	2	UniProt (P25789) Pfam (PF10584) Pfam (PF00227) In PDB	HOMO SAPIENS (HUMAN)	MACROPAIN SUBUNIT C9, MULTICATALYTIC ENDOPEPTIDASE COMPLEX SUBUNIT C9, PROTEASOME COMPONENT C9, PROTEASOME SUBUNIT L
4	D, R	PROTEASOME SUBUNIT ALPHA TYPE-7	polymer	248	27929.9	2	UniProt (O14818) Pfam (PF10584) Pfam (PF00227) In PDB	HOMO SAPIENS (HUMAN)	PROTEASOME SUBUNIT RC6-1, PROTEASOME SUBUNIT XAPC7
5	E, S	PROTEASOME SUBUNIT ALPHA TYPE-5	polymer	241	26436.0	2	UniProt (P28066) Pfam (PF00227) Pfam (PF10584) In PDB	HOMO SAPIENS (HUMAN)	MACROPAIN ZETA CHAIN, MULTICATALYTIC ENDOPEPTIDASE COMPLEX ZETA CHAIN, PROTEASOME ZETA CHAIN
6	F, T	PROTEASOME SUBUNIT ALPHA TYPE-1	polymer	263	29595.6	2	UniProt (P25786) Pfam (PF10584) Pfam (PF00227) In PDB	HOMO SAPIENS (HUMAN)	30 KDA PROSOMAL PROTEIN, PROS-30, MACROPAIN SUBUNIT C2, MULTICATALYTIC ENDOPEPTIDASE COMPLEX SUBUNIT C2, PROTEASOME COMPONENT C2, PROTEASOME NU CHAIN
7	G, U	PROTEASOME SUBUNIT ALPHA TYPE-3	polymer	255	28469.3	2	UniProt (P25788) Pfam (PF10584) Pfam (PF00227) In PDB	HOMO SAPIENS (HUMAN)	MACROPAIN SUBUNIT C8, MULTICATALYTIC ENDOPEPTIDASE COMPLEX SUBUNIT C8, PROTEASOME COMPONENT C8
8	H, V	PROTEASOME SUBUNIT BETA TYPE-6	polymer	205	21921.8	2	UniProt (P28072) Pfam (PF00227) In PDB	HOMO SAPIENS (HUMAN)	MACROPAIN DELTA CHAIN, MULTICATALYTIC ENDOPEPTIDASE COMPLEX DELTA CHAIN, PROTEASOME DELTA CHAIN, PROTEASOME SUBUNIT Y
9	I, W	PROTEASOME SUBUNIT BETA TYPE-7	polymer	234	25322.0	2	UniProt (Q99436) Pfam (PF00227) Pfam (PF12465) In PDB	HOMO SAPIENS (HUMAN)	MACROPAIN CHAIN Z, MULTICATALYTIC ENDOPEPTIDASE COMPLEX CHAIN Z, PROTEASOME SUBUNIT Z
10	J, X	PROTEASOME SUBUNIT BETA TYPE-3	polymer	204	22841.7	2	UniProt (P49720) Pfam (PF00227) In PDB	HOMO SAPIENS (HUMAN)	PROTEASOME CHAIN 13, PROTEASOME COMPONENT C10-II, PROTEASOME THETA CHAIN
11	K, Y	PROTEASOME SUBUNIT BETA TYPE-2	polymer	201	22864.3	2	UniProt (P49721) Pfam (PF00227) In PDB	HOMO SAPIENS (HUMAN)	MACROPAIN SUBUNIT C7-I, MULTICATALYTIC ENDOPEPTIDASE COMPLEX SUBUNIT C7-I, PROTEASOME COMPONENT C7-I
12	L, Z	PROTEASOME SUBUNIT BETA TYPE-5	polymer	204	22484.4	2	UniProt (P28074) Pfam (PF00227) In PDB	HOMO SAPIENS (HUMAN)	MACROPAIN EPSILON CHAIN, MULTICATALYTIC ENDOPEPTIDASE COMPLEX EPSILON CHAIN, PROTEASOME CHAIN 6, PROTEASOME EPSILON CHAIN, PROTEASOME SUBUNIT MB1, PROTEASOME SUBUNIT X
13	M, a	PROTEASOME SUBUNIT BETA TYPE-1	polymer	213	23579.0	2	UniProt (P20618) Pfam (PF00227) In PDB	HOMO SAPIENS (HUMAN)	MACROPAIN SUBUNIT C5, MULTICATALYTIC ENDOPEPTIDASE COMPLEX SUBUNIT C5, PROTEASOME COMPONENT C5, PROTEASOME GAMMA CHAIN
14	N, b	PROTEASOME SUBUNIT BETA TYPE-4	polymer	219	24414.7	2	UniProt (P28070) Pfam (PF00227) In PDB	HOMO SAPIENS (HUMAN)	26 KDA PROSOMAL PROTEIN, PROS-26, MACROPAIN BETA CHAIN, MULTICATALYTIC ENDOPEPTIDASE COMPLEX BETA CHAIN, PROTEASOME BETA CHAIN, PROTEASOME CHAIN 3, HSN3
15	H, I, L, V, W...	ADA-(AHX)3-(LEU)3-VINYL SULFONE	non-polymer		949.4	6	Chemie (KNM)

Contents of the asymmetric unit

Polymers	Number of chains	28
	Total formula weight	717488.9
Non-Polymers*	Number of molecules	6
	Total formula weight	5696.3
All*	Total formula weight	723185.2

*Water molecules are not included.