5A0Q

Cryo-EM reveals the conformation of a substrate analogue in the human 20S proteasome core

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000502	cellular_component	proteasome complex
A	0000932	cellular_component	P-body
A	0002376	biological_process	immune system process
A	0003723	molecular_function	RNA binding
A	0004175	molecular_function	endopeptidase activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005839	cellular_component	proteasome core complex
A	0005840	cellular_component	ribosome
A	0006281	biological_process	DNA repair
A	0006511	biological_process	ubiquitin-dependent protein catabolic process
A	0006915	biological_process	apoptotic process
A	0006974	biological_process	DNA damage response
A	0006979	biological_process	response to oxidative stress
A	0007283	biological_process	spermatogenesis
A	0008021	cellular_component	synaptic vesicle
A	0010498	biological_process	proteasomal protein catabolic process
A	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
A	0016363	cellular_component	nuclear matrix
A	0019773	cellular_component	proteasome core complex, alpha-subunit complex
A	0030016	cellular_component	myofibril
A	0030017	cellular_component	sarcomere
A	0030317	biological_process	flagellated sperm motility
A	0032729	biological_process	positive regulation of type II interferon production
A	0032743	biological_process	positive regulation of interleukin-2 production
A	0032760	biological_process	positive regulation of tumor necrosis factor production
A	0034341	biological_process	response to type II interferon
A	0034515	cellular_component	proteasome storage granule
A	0035639	molecular_function	purine ribonucleoside triphosphate binding
A	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
A	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
A	0043374	biological_process	CD8-positive, alpha-beta T cell differentiation
A	0045061	biological_process	thymic T cell selection
A	0045063	biological_process	T-helper 1 cell differentiation
A	0045590	biological_process	negative regulation of regulatory T cell differentiation
A	0050727	biological_process	regulation of inflammatory response
A	0051059	molecular_function	NF-kappaB binding
A	0051321	biological_process	meiotic cell cycle
A	0051603	biological_process	proteolysis involved in protein catabolic process
A	0061136	biological_process	regulation of proteasomal protein catabolic process
A	0070062	cellular_component	extracellular exosome
A	0071357	biological_process	cellular response to type I interferon
A	0072539	biological_process	T-helper 17 cell differentiation
A	0097229	cellular_component	sperm end piece
A	0097542	cellular_component	ciliary tip
A	0160165	biological_process	CD8-positive, alpha-beta T cell homeostasis
A	1990111	cellular_component	spermatoproteasome complex
A	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
B	0000502	cellular_component	proteasome complex
B	0000932	cellular_component	P-body
B	0002376	biological_process	immune system process
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005839	cellular_component	proteasome core complex
B	0006281	biological_process	DNA repair
B	0006511	biological_process	ubiquitin-dependent protein catabolic process
B	0006915	biological_process	apoptotic process
B	0006974	biological_process	DNA damage response
B	0006979	biological_process	response to oxidative stress
B	0007283	biological_process	spermatogenesis
B	0008021	cellular_component	synaptic vesicle
B	0009615	biological_process	response to virus
B	0010498	biological_process	proteasomal protein catabolic process
B	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
B	0019773	cellular_component	proteasome core complex, alpha-subunit complex
B	0030317	biological_process	flagellated sperm motility
B	0032729	biological_process	positive regulation of type II interferon production
B	0032743	biological_process	positive regulation of interleukin-2 production
B	0032760	biological_process	positive regulation of tumor necrosis factor production
B	0034341	biological_process	response to type II interferon
B	0034515	cellular_component	proteasome storage granule
B	0034774	cellular_component	secretory granule lumen
B	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
B	0043374	biological_process	CD8-positive, alpha-beta T cell differentiation
B	0045061	biological_process	thymic T cell selection
B	0045063	biological_process	T-helper 1 cell differentiation
B	0045590	biological_process	negative regulation of regulatory T cell differentiation
B	0051321	biological_process	meiotic cell cycle
B	0051603	biological_process	proteolysis involved in protein catabolic process
B	0061136	biological_process	regulation of proteasomal protein catabolic process
B	0070062	cellular_component	extracellular exosome
B	0071357	biological_process	cellular response to type I interferon
B	0072539	biological_process	T-helper 17 cell differentiation
B	0160165	biological_process	CD8-positive, alpha-beta T cell homeostasis
B	1904813	cellular_component	ficolin-1-rich granule lumen
B	1990111	cellular_component	spermatoproteasome complex
B	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
C	0000502	cellular_component	proteasome complex
C	0000932	cellular_component	P-body
C	0002376	biological_process	immune system process
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0005839	cellular_component	proteasome core complex
C	0006281	biological_process	DNA repair
C	0006511	biological_process	ubiquitin-dependent protein catabolic process
C	0006915	biological_process	apoptotic process
C	0006974	biological_process	DNA damage response
C	0006979	biological_process	response to oxidative stress
C	0007283	biological_process	spermatogenesis
C	0008021	cellular_component	synaptic vesicle
C	0010498	biological_process	proteasomal protein catabolic process
C	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
C	0019773	cellular_component	proteasome core complex, alpha-subunit complex
C	0030317	biological_process	flagellated sperm motility
C	0032729	biological_process	positive regulation of type II interferon production
C	0032743	biological_process	positive regulation of interleukin-2 production
C	0032760	biological_process	positive regulation of tumor necrosis factor production
C	0034341	biological_process	response to type II interferon
C	0034515	cellular_component	proteasome storage granule
C	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
C	0043374	biological_process	CD8-positive, alpha-beta T cell differentiation
C	0045061	biological_process	thymic T cell selection
C	0045063	biological_process	T-helper 1 cell differentiation
C	0045590	biological_process	negative regulation of regulatory T cell differentiation
C	0051321	biological_process	meiotic cell cycle
C	0051603	biological_process	proteolysis involved in protein catabolic process
C	0061136	biological_process	regulation of proteasomal protein catabolic process
C	0070062	cellular_component	extracellular exosome
C	0071357	biological_process	cellular response to type I interferon
C	0072539	biological_process	T-helper 17 cell differentiation
C	0160165	biological_process	CD8-positive, alpha-beta T cell homeostasis
C	1990111	cellular_component	spermatoproteasome complex
C	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
D	0000502	cellular_component	proteasome complex
D	0002376	biological_process	immune system process
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0005839	cellular_component	proteasome core complex
D	0006281	biological_process	DNA repair
D	0006511	biological_process	ubiquitin-dependent protein catabolic process
D	0006915	biological_process	apoptotic process
D	0006974	biological_process	DNA damage response
D	0006979	biological_process	response to oxidative stress
D	0008021	cellular_component	synaptic vesicle
D	0010498	biological_process	proteasomal protein catabolic process
D	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
D	0019773	cellular_component	proteasome core complex, alpha-subunit complex
D	0030317	biological_process	flagellated sperm motility
D	0032729	biological_process	positive regulation of type II interferon production
D	0032743	biological_process	positive regulation of interleukin-2 production
D	0032760	biological_process	positive regulation of tumor necrosis factor production
D	0034341	biological_process	response to type II interferon
D	0034515	cellular_component	proteasome storage granule
D	0042802	molecular_function	identical protein binding
D	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
D	0043374	biological_process	CD8-positive, alpha-beta T cell differentiation
D	0045061	biological_process	thymic T cell selection
D	0045063	biological_process	T-helper 1 cell differentiation
D	0045590	biological_process	negative regulation of regulatory T cell differentiation
D	0051603	biological_process	proteolysis involved in protein catabolic process
D	0061136	biological_process	regulation of proteasomal protein catabolic process
D	0070062	cellular_component	extracellular exosome
D	0071357	biological_process	cellular response to type I interferon
D	0072539	biological_process	T-helper 17 cell differentiation
D	0160165	biological_process	CD8-positive, alpha-beta T cell homeostasis
D	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
E	0000502	cellular_component	proteasome complex
E	0002376	biological_process	immune system process
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0005839	cellular_component	proteasome core complex
E	0006281	biological_process	DNA repair
E	0006511	biological_process	ubiquitin-dependent protein catabolic process
E	0006915	biological_process	apoptotic process
E	0006974	biological_process	DNA damage response
E	0006979	biological_process	response to oxidative stress
E	0007283	biological_process	spermatogenesis
E	0008021	cellular_component	synaptic vesicle
E	0010498	biological_process	proteasomal protein catabolic process
E	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
E	0019773	cellular_component	proteasome core complex, alpha-subunit complex
E	0030317	biological_process	flagellated sperm motility
E	0032729	biological_process	positive regulation of type II interferon production
E	0032743	biological_process	positive regulation of interleukin-2 production
E	0032760	biological_process	positive regulation of tumor necrosis factor production
E	0034341	biological_process	response to type II interferon
E	0034515	cellular_component	proteasome storage granule
E	0034774	cellular_component	secretory granule lumen
E	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
E	0043374	biological_process	CD8-positive, alpha-beta T cell differentiation
E	0045061	biological_process	thymic T cell selection
E	0045063	biological_process	T-helper 1 cell differentiation
E	0045590	biological_process	negative regulation of regulatory T cell differentiation
E	0051321	biological_process	meiotic cell cycle
E	0051603	biological_process	proteolysis involved in protein catabolic process
E	0061136	biological_process	regulation of proteasomal protein catabolic process
E	0070062	cellular_component	extracellular exosome
E	0071357	biological_process	cellular response to type I interferon
E	0072539	biological_process	T-helper 17 cell differentiation
E	0160165	biological_process	CD8-positive, alpha-beta T cell homeostasis
E	1904813	cellular_component	ficolin-1-rich granule lumen
E	1990111	cellular_component	spermatoproteasome complex
E	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
F	0000502	cellular_component	proteasome complex
F	0001530	molecular_function	lipopolysaccharide binding
F	0002376	biological_process	immune system process
F	0002862	biological_process	negative regulation of inflammatory response to antigenic stimulus
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0005839	cellular_component	proteasome core complex
F	0006281	biological_process	DNA repair
F	0006511	biological_process	ubiquitin-dependent protein catabolic process
F	0006915	biological_process	apoptotic process
F	0006974	biological_process	DNA damage response
F	0006979	biological_process	response to oxidative stress
F	0007283	biological_process	spermatogenesis
F	0008021	cellular_component	synaptic vesicle
F	0010498	biological_process	proteasomal protein catabolic process
F	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
F	0016604	cellular_component	nuclear body
F	0019773	cellular_component	proteasome core complex, alpha-subunit complex
F	0030317	biological_process	flagellated sperm motility
F	0032729	biological_process	positive regulation of type II interferon production
F	0032743	biological_process	positive regulation of interleukin-2 production
F	0032760	biological_process	positive regulation of tumor necrosis factor production
F	0034341	biological_process	response to type II interferon
F	0034515	cellular_component	proteasome storage granule
F	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
F	0043374	biological_process	CD8-positive, alpha-beta T cell differentiation
F	0045061	biological_process	thymic T cell selection
F	0045063	biological_process	T-helper 1 cell differentiation
F	0045590	biological_process	negative regulation of regulatory T cell differentiation
F	0051321	biological_process	meiotic cell cycle
F	0051603	biological_process	proteolysis involved in protein catabolic process
F	0061136	biological_process	regulation of proteasomal protein catabolic process
F	0070062	cellular_component	extracellular exosome
F	0071357	biological_process	cellular response to type I interferon
F	0072539	biological_process	T-helper 17 cell differentiation
F	0160165	biological_process	CD8-positive, alpha-beta T cell homeostasis
F	1990111	cellular_component	spermatoproteasome complex
F	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
G	0000502	cellular_component	proteasome complex
G	0002376	biological_process	immune system process
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0005839	cellular_component	proteasome core complex
G	0006281	biological_process	DNA repair
G	0006511	biological_process	ubiquitin-dependent protein catabolic process
G	0006915	biological_process	apoptotic process
G	0006974	biological_process	DNA damage response
G	0006979	biological_process	response to oxidative stress
G	0007283	biological_process	spermatogenesis
G	0008021	cellular_component	synaptic vesicle
G	0010498	biological_process	proteasomal protein catabolic process
G	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
G	0019773	cellular_component	proteasome core complex, alpha-subunit complex
G	0030317	biological_process	flagellated sperm motility
G	0031625	molecular_function	ubiquitin protein ligase binding
G	0032729	biological_process	positive regulation of type II interferon production
G	0032743	biological_process	positive regulation of interleukin-2 production
G	0032760	biological_process	positive regulation of tumor necrosis factor production
G	0034341	biological_process	response to type II interferon
G	0034515	cellular_component	proteasome storage granule
G	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
G	0043374	biological_process	CD8-positive, alpha-beta T cell differentiation
G	0045061	biological_process	thymic T cell selection
G	0045063	biological_process	T-helper 1 cell differentiation
G	0045590	biological_process	negative regulation of regulatory T cell differentiation
G	0051321	biological_process	meiotic cell cycle
G	0051603	biological_process	proteolysis involved in protein catabolic process
G	0061136	biological_process	regulation of proteasomal protein catabolic process
G	0070062	cellular_component	extracellular exosome
G	0071357	biological_process	cellular response to type I interferon
G	0072539	biological_process	T-helper 17 cell differentiation
G	0160165	biological_process	CD8-positive, alpha-beta T cell homeostasis
G	1990111	cellular_component	spermatoproteasome complex
G	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
H	0004298	molecular_function	threonine-type endopeptidase activity
H	0005839	cellular_component	proteasome core complex
H	0051603	biological_process	proteolysis involved in protein catabolic process
I	0004298	molecular_function	threonine-type endopeptidase activity
I	0005839	cellular_component	proteasome core complex
I	0051603	biological_process	proteolysis involved in protein catabolic process
J	0000502	cellular_component	proteasome complex
J	0002376	biological_process	immune system process
J	0005515	molecular_function	protein binding
J	0005634	cellular_component	nucleus
J	0005654	cellular_component	nucleoplasm
J	0005737	cellular_component	cytoplasm
J	0005829	cellular_component	cytosol
J	0005839	cellular_component	proteasome core complex
J	0006281	biological_process	DNA repair
J	0006915	biological_process	apoptotic process
J	0006974	biological_process	DNA damage response
J	0006979	biological_process	response to oxidative stress
J	0007283	biological_process	spermatogenesis
J	0008021	cellular_component	synaptic vesicle
J	0010498	biological_process	proteasomal protein catabolic process
J	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
J	0019774	cellular_component	proteasome core complex, beta-subunit complex
J	0030317	biological_process	flagellated sperm motility
J	0032729	biological_process	positive regulation of type II interferon production
J	0032743	biological_process	positive regulation of interleukin-2 production
J	0032760	biological_process	positive regulation of tumor necrosis factor production
J	0034341	biological_process	response to type II interferon
J	0034515	cellular_component	proteasome storage granule
J	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
J	0043374	biological_process	CD8-positive, alpha-beta T cell differentiation
J	0045061	biological_process	thymic T cell selection
J	0045063	biological_process	T-helper 1 cell differentiation
J	0045590	biological_process	negative regulation of regulatory T cell differentiation
J	0051321	biological_process	meiotic cell cycle
J	0051603	biological_process	proteolysis involved in protein catabolic process
J	0061136	biological_process	regulation of proteasomal protein catabolic process
J	0070062	cellular_component	extracellular exosome
J	0071357	biological_process	cellular response to type I interferon
J	0072539	biological_process	T-helper 17 cell differentiation
J	0160165	biological_process	CD8-positive, alpha-beta T cell homeostasis
J	1990111	cellular_component	spermatoproteasome complex
J	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
K	0000502	cellular_component	proteasome complex
K	0002376	biological_process	immune system process
K	0005515	molecular_function	protein binding
K	0005634	cellular_component	nucleus
K	0005654	cellular_component	nucleoplasm
K	0005737	cellular_component	cytoplasm
K	0005829	cellular_component	cytosol
K	0005839	cellular_component	proteasome core complex
K	0006281	biological_process	DNA repair
K	0006915	biological_process	apoptotic process
K	0006974	biological_process	DNA damage response
K	0006979	biological_process	response to oxidative stress
K	0007283	biological_process	spermatogenesis
K	0008021	cellular_component	synaptic vesicle
K	0010498	biological_process	proteasomal protein catabolic process
K	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
K	0016020	cellular_component	membrane
K	0019774	cellular_component	proteasome core complex, beta-subunit complex
K	0030317	biological_process	flagellated sperm motility
K	0032729	biological_process	positive regulation of type II interferon production
K	0032743	biological_process	positive regulation of interleukin-2 production
K	0032760	biological_process	positive regulation of tumor necrosis factor production
K	0034341	biological_process	response to type II interferon
K	0034515	cellular_component	proteasome storage granule
K	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
K	0043374	biological_process	CD8-positive, alpha-beta T cell differentiation
K	0045061	biological_process	thymic T cell selection
K	0045063	biological_process	T-helper 1 cell differentiation
K	0045590	biological_process	negative regulation of regulatory T cell differentiation
K	0051321	biological_process	meiotic cell cycle
K	0051603	biological_process	proteolysis involved in protein catabolic process
K	0061136	biological_process	regulation of proteasomal protein catabolic process
K	0070062	cellular_component	extracellular exosome
K	0071357	biological_process	cellular response to type I interferon
K	0072539	biological_process	T-helper 17 cell differentiation
K	0160165	biological_process	CD8-positive, alpha-beta T cell homeostasis
K	1990111	cellular_component	spermatoproteasome complex
K	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
L	0004298	molecular_function	threonine-type endopeptidase activity
L	0005839	cellular_component	proteasome core complex
L	0051603	biological_process	proteolysis involved in protein catabolic process
M	0005839	cellular_component	proteasome core complex
M	0051603	biological_process	proteolysis involved in protein catabolic process
N	0005839	cellular_component	proteasome core complex
N	0051603	biological_process	proteolysis involved in protein catabolic process
O	0000502	cellular_component	proteasome complex
O	0000932	cellular_component	P-body
O	0002376	biological_process	immune system process
O	0003723	molecular_function	RNA binding
O	0004175	molecular_function	endopeptidase activity
O	0005515	molecular_function	protein binding
O	0005634	cellular_component	nucleus
O	0005654	cellular_component	nucleoplasm
O	0005737	cellular_component	cytoplasm
O	0005829	cellular_component	cytosol
O	0005839	cellular_component	proteasome core complex
O	0005840	cellular_component	ribosome
O	0006281	biological_process	DNA repair
O	0006511	biological_process	ubiquitin-dependent protein catabolic process
O	0006915	biological_process	apoptotic process
O	0006974	biological_process	DNA damage response
O	0006979	biological_process	response to oxidative stress
O	0007283	biological_process	spermatogenesis
O	0008021	cellular_component	synaptic vesicle
O	0010498	biological_process	proteasomal protein catabolic process
O	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
O	0016363	cellular_component	nuclear matrix
O	0019773	cellular_component	proteasome core complex, alpha-subunit complex
O	0030016	cellular_component	myofibril
O	0030017	cellular_component	sarcomere
O	0030317	biological_process	flagellated sperm motility
O	0032729	biological_process	positive regulation of type II interferon production
O	0032743	biological_process	positive regulation of interleukin-2 production
O	0032760	biological_process	positive regulation of tumor necrosis factor production
O	0034341	biological_process	response to type II interferon
O	0034515	cellular_component	proteasome storage granule
O	0035639	molecular_function	purine ribonucleoside triphosphate binding
O	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
O	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
O	0043374	biological_process	CD8-positive, alpha-beta T cell differentiation
O	0045061	biological_process	thymic T cell selection
O	0045063	biological_process	T-helper 1 cell differentiation
O	0045590	biological_process	negative regulation of regulatory T cell differentiation
O	0050727	biological_process	regulation of inflammatory response
O	0051059	molecular_function	NF-kappaB binding
O	0051321	biological_process	meiotic cell cycle
O	0051603	biological_process	proteolysis involved in protein catabolic process
O	0061136	biological_process	regulation of proteasomal protein catabolic process
O	0070062	cellular_component	extracellular exosome
O	0071357	biological_process	cellular response to type I interferon
O	0072539	biological_process	T-helper 17 cell differentiation
O	0097229	cellular_component	sperm end piece
O	0097542	cellular_component	ciliary tip
O	0160165	biological_process	CD8-positive, alpha-beta T cell homeostasis
O	1990111	cellular_component	spermatoproteasome complex
O	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
P	0000502	cellular_component	proteasome complex
P	0000932	cellular_component	P-body
P	0002376	biological_process	immune system process
P	0005515	molecular_function	protein binding
P	0005576	cellular_component	extracellular region
P	0005634	cellular_component	nucleus
P	0005654	cellular_component	nucleoplasm
P	0005737	cellular_component	cytoplasm
P	0005829	cellular_component	cytosol
P	0005839	cellular_component	proteasome core complex
P	0006281	biological_process	DNA repair
P	0006511	biological_process	ubiquitin-dependent protein catabolic process
P	0006915	biological_process	apoptotic process
P	0006974	biological_process	DNA damage response
P	0006979	biological_process	response to oxidative stress
P	0007283	biological_process	spermatogenesis
P	0008021	cellular_component	synaptic vesicle
P	0009615	biological_process	response to virus
P	0010498	biological_process	proteasomal protein catabolic process
P	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
P	0019773	cellular_component	proteasome core complex, alpha-subunit complex
P	0030317	biological_process	flagellated sperm motility
P	0032729	biological_process	positive regulation of type II interferon production
P	0032743	biological_process	positive regulation of interleukin-2 production
P	0032760	biological_process	positive regulation of tumor necrosis factor production
P	0034341	biological_process	response to type II interferon
P	0034515	cellular_component	proteasome storage granule
P	0034774	cellular_component	secretory granule lumen
P	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
P	0043374	biological_process	CD8-positive, alpha-beta T cell differentiation
P	0045061	biological_process	thymic T cell selection
P	0045063	biological_process	T-helper 1 cell differentiation
P	0045590	biological_process	negative regulation of regulatory T cell differentiation
P	0051321	biological_process	meiotic cell cycle
P	0051603	biological_process	proteolysis involved in protein catabolic process
P	0061136	biological_process	regulation of proteasomal protein catabolic process
P	0070062	cellular_component	extracellular exosome
P	0071357	biological_process	cellular response to type I interferon
P	0072539	biological_process	T-helper 17 cell differentiation
P	0160165	biological_process	CD8-positive, alpha-beta T cell homeostasis
P	1904813	cellular_component	ficolin-1-rich granule lumen
P	1990111	cellular_component	spermatoproteasome complex
P	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
Q	0000502	cellular_component	proteasome complex
Q	0000932	cellular_component	P-body
Q	0002376	biological_process	immune system process
Q	0005515	molecular_function	protein binding
Q	0005634	cellular_component	nucleus
Q	0005654	cellular_component	nucleoplasm
Q	0005737	cellular_component	cytoplasm
Q	0005829	cellular_component	cytosol
Q	0005839	cellular_component	proteasome core complex
Q	0006281	biological_process	DNA repair
Q	0006511	biological_process	ubiquitin-dependent protein catabolic process
Q	0006915	biological_process	apoptotic process
Q	0006974	biological_process	DNA damage response
Q	0006979	biological_process	response to oxidative stress
Q	0007283	biological_process	spermatogenesis
Q	0008021	cellular_component	synaptic vesicle
Q	0010498	biological_process	proteasomal protein catabolic process
Q	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
Q	0019773	cellular_component	proteasome core complex, alpha-subunit complex
Q	0030317	biological_process	flagellated sperm motility
Q	0032729	biological_process	positive regulation of type II interferon production
Q	0032743	biological_process	positive regulation of interleukin-2 production
Q	0032760	biological_process	positive regulation of tumor necrosis factor production
Q	0034341	biological_process	response to type II interferon
Q	0034515	cellular_component	proteasome storage granule
Q	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
Q	0043374	biological_process	CD8-positive, alpha-beta T cell differentiation
Q	0045061	biological_process	thymic T cell selection
Q	0045063	biological_process	T-helper 1 cell differentiation
Q	0045590	biological_process	negative regulation of regulatory T cell differentiation
Q	0051321	biological_process	meiotic cell cycle
Q	0051603	biological_process	proteolysis involved in protein catabolic process
Q	0061136	biological_process	regulation of proteasomal protein catabolic process
Q	0070062	cellular_component	extracellular exosome
Q	0071357	biological_process	cellular response to type I interferon
Q	0072539	biological_process	T-helper 17 cell differentiation
Q	0160165	biological_process	CD8-positive, alpha-beta T cell homeostasis
Q	1990111	cellular_component	spermatoproteasome complex
Q	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
R	0000502	cellular_component	proteasome complex
R	0002376	biological_process	immune system process
R	0005515	molecular_function	protein binding
R	0005634	cellular_component	nucleus
R	0005654	cellular_component	nucleoplasm
R	0005737	cellular_component	cytoplasm
R	0005829	cellular_component	cytosol
R	0005839	cellular_component	proteasome core complex
R	0006281	biological_process	DNA repair
R	0006511	biological_process	ubiquitin-dependent protein catabolic process
R	0006915	biological_process	apoptotic process
R	0006974	biological_process	DNA damage response
R	0006979	biological_process	response to oxidative stress
R	0008021	cellular_component	synaptic vesicle
R	0010498	biological_process	proteasomal protein catabolic process
R	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
R	0019773	cellular_component	proteasome core complex, alpha-subunit complex
R	0030317	biological_process	flagellated sperm motility
R	0032729	biological_process	positive regulation of type II interferon production
R	0032743	biological_process	positive regulation of interleukin-2 production
R	0032760	biological_process	positive regulation of tumor necrosis factor production
R	0034341	biological_process	response to type II interferon
R	0034515	cellular_component	proteasome storage granule
R	0042802	molecular_function	identical protein binding
R	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
R	0043374	biological_process	CD8-positive, alpha-beta T cell differentiation
R	0045061	biological_process	thymic T cell selection
R	0045063	biological_process	T-helper 1 cell differentiation
R	0045590	biological_process	negative regulation of regulatory T cell differentiation
R	0051603	biological_process	proteolysis involved in protein catabolic process
R	0061136	biological_process	regulation of proteasomal protein catabolic process
R	0070062	cellular_component	extracellular exosome
R	0071357	biological_process	cellular response to type I interferon
R	0072539	biological_process	T-helper 17 cell differentiation
R	0160165	biological_process	CD8-positive, alpha-beta T cell homeostasis
R	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
S	0000502	cellular_component	proteasome complex
S	0002376	biological_process	immune system process
S	0005515	molecular_function	protein binding
S	0005576	cellular_component	extracellular region
S	0005634	cellular_component	nucleus
S	0005654	cellular_component	nucleoplasm
S	0005737	cellular_component	cytoplasm
S	0005829	cellular_component	cytosol
S	0005839	cellular_component	proteasome core complex
S	0006281	biological_process	DNA repair
S	0006511	biological_process	ubiquitin-dependent protein catabolic process
S	0006915	biological_process	apoptotic process
S	0006974	biological_process	DNA damage response
S	0006979	biological_process	response to oxidative stress
S	0007283	biological_process	spermatogenesis
S	0008021	cellular_component	synaptic vesicle
S	0010498	biological_process	proteasomal protein catabolic process
S	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
S	0019773	cellular_component	proteasome core complex, alpha-subunit complex
S	0030317	biological_process	flagellated sperm motility
S	0032729	biological_process	positive regulation of type II interferon production
S	0032743	biological_process	positive regulation of interleukin-2 production
S	0032760	biological_process	positive regulation of tumor necrosis factor production
S	0034341	biological_process	response to type II interferon
S	0034515	cellular_component	proteasome storage granule
S	0034774	cellular_component	secretory granule lumen
S	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
S	0043374	biological_process	CD8-positive, alpha-beta T cell differentiation
S	0045061	biological_process	thymic T cell selection
S	0045063	biological_process	T-helper 1 cell differentiation
S	0045590	biological_process	negative regulation of regulatory T cell differentiation
S	0051321	biological_process	meiotic cell cycle
S	0051603	biological_process	proteolysis involved in protein catabolic process
S	0061136	biological_process	regulation of proteasomal protein catabolic process
S	0070062	cellular_component	extracellular exosome
S	0071357	biological_process	cellular response to type I interferon
S	0072539	biological_process	T-helper 17 cell differentiation
S	0160165	biological_process	CD8-positive, alpha-beta T cell homeostasis
S	1904813	cellular_component	ficolin-1-rich granule lumen
S	1990111	cellular_component	spermatoproteasome complex
S	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
T	0000502	cellular_component	proteasome complex
T	0001530	molecular_function	lipopolysaccharide binding
T	0002376	biological_process	immune system process
T	0002862	biological_process	negative regulation of inflammatory response to antigenic stimulus
T	0005515	molecular_function	protein binding
T	0005634	cellular_component	nucleus
T	0005654	cellular_component	nucleoplasm
T	0005737	cellular_component	cytoplasm
T	0005829	cellular_component	cytosol
T	0005839	cellular_component	proteasome core complex
T	0006281	biological_process	DNA repair
T	0006511	biological_process	ubiquitin-dependent protein catabolic process
T	0006915	biological_process	apoptotic process
T	0006974	biological_process	DNA damage response
T	0006979	biological_process	response to oxidative stress
T	0007283	biological_process	spermatogenesis
T	0008021	cellular_component	synaptic vesicle
T	0010498	biological_process	proteasomal protein catabolic process
T	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
T	0016604	cellular_component	nuclear body
T	0019773	cellular_component	proteasome core complex, alpha-subunit complex
T	0030317	biological_process	flagellated sperm motility
T	0032729	biological_process	positive regulation of type II interferon production
T	0032743	biological_process	positive regulation of interleukin-2 production
T	0032760	biological_process	positive regulation of tumor necrosis factor production
T	0034341	biological_process	response to type II interferon
T	0034515	cellular_component	proteasome storage granule
T	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
T	0043374	biological_process	CD8-positive, alpha-beta T cell differentiation
T	0045061	biological_process	thymic T cell selection
T	0045063	biological_process	T-helper 1 cell differentiation
T	0045590	biological_process	negative regulation of regulatory T cell differentiation
T	0051321	biological_process	meiotic cell cycle
T	0051603	biological_process	proteolysis involved in protein catabolic process
T	0061136	biological_process	regulation of proteasomal protein catabolic process
T	0070062	cellular_component	extracellular exosome
T	0071357	biological_process	cellular response to type I interferon
T	0072539	biological_process	T-helper 17 cell differentiation
T	0160165	biological_process	CD8-positive, alpha-beta T cell homeostasis
T	1990111	cellular_component	spermatoproteasome complex
T	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
U	0000502	cellular_component	proteasome complex
U	0002376	biological_process	immune system process
U	0005515	molecular_function	protein binding
U	0005634	cellular_component	nucleus
U	0005654	cellular_component	nucleoplasm
U	0005737	cellular_component	cytoplasm
U	0005829	cellular_component	cytosol
U	0005839	cellular_component	proteasome core complex
U	0006281	biological_process	DNA repair
U	0006511	biological_process	ubiquitin-dependent protein catabolic process
U	0006915	biological_process	apoptotic process
U	0006974	biological_process	DNA damage response
U	0006979	biological_process	response to oxidative stress
U	0007283	biological_process	spermatogenesis
U	0008021	cellular_component	synaptic vesicle
U	0010498	biological_process	proteasomal protein catabolic process
U	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
U	0019773	cellular_component	proteasome core complex, alpha-subunit complex
U	0030317	biological_process	flagellated sperm motility
U	0031625	molecular_function	ubiquitin protein ligase binding
U	0032729	biological_process	positive regulation of type II interferon production
U	0032743	biological_process	positive regulation of interleukin-2 production
U	0032760	biological_process	positive regulation of tumor necrosis factor production
U	0034341	biological_process	response to type II interferon
U	0034515	cellular_component	proteasome storage granule
U	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
U	0043374	biological_process	CD8-positive, alpha-beta T cell differentiation
U	0045061	biological_process	thymic T cell selection
U	0045063	biological_process	T-helper 1 cell differentiation
U	0045590	biological_process	negative regulation of regulatory T cell differentiation
U	0051321	biological_process	meiotic cell cycle
U	0051603	biological_process	proteolysis involved in protein catabolic process
U	0061136	biological_process	regulation of proteasomal protein catabolic process
U	0070062	cellular_component	extracellular exosome
U	0071357	biological_process	cellular response to type I interferon
U	0072539	biological_process	T-helper 17 cell differentiation
U	0160165	biological_process	CD8-positive, alpha-beta T cell homeostasis
U	1990111	cellular_component	spermatoproteasome complex
U	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
V	0004298	molecular_function	threonine-type endopeptidase activity
V	0005839	cellular_component	proteasome core complex
V	0051603	biological_process	proteolysis involved in protein catabolic process
W	0004298	molecular_function	threonine-type endopeptidase activity
W	0005839	cellular_component	proteasome core complex
W	0051603	biological_process	proteolysis involved in protein catabolic process
X	0000502	cellular_component	proteasome complex
X	0002376	biological_process	immune system process
X	0005515	molecular_function	protein binding
X	0005634	cellular_component	nucleus
X	0005654	cellular_component	nucleoplasm
X	0005737	cellular_component	cytoplasm
X	0005829	cellular_component	cytosol
X	0005839	cellular_component	proteasome core complex
X	0006281	biological_process	DNA repair
X	0006915	biological_process	apoptotic process
X	0006974	biological_process	DNA damage response
X	0006979	biological_process	response to oxidative stress
X	0007283	biological_process	spermatogenesis
X	0008021	cellular_component	synaptic vesicle
X	0010498	biological_process	proteasomal protein catabolic process
X	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
X	0019774	cellular_component	proteasome core complex, beta-subunit complex
X	0030317	biological_process	flagellated sperm motility
X	0032729	biological_process	positive regulation of type II interferon production
X	0032743	biological_process	positive regulation of interleukin-2 production
X	0032760	biological_process	positive regulation of tumor necrosis factor production
X	0034341	biological_process	response to type II interferon
X	0034515	cellular_component	proteasome storage granule
X	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
X	0043374	biological_process	CD8-positive, alpha-beta T cell differentiation
X	0045061	biological_process	thymic T cell selection
X	0045063	biological_process	T-helper 1 cell differentiation
X	0045590	biological_process	negative regulation of regulatory T cell differentiation
X	0051321	biological_process	meiotic cell cycle
X	0051603	biological_process	proteolysis involved in protein catabolic process
X	0061136	biological_process	regulation of proteasomal protein catabolic process
X	0070062	cellular_component	extracellular exosome
X	0071357	biological_process	cellular response to type I interferon
X	0072539	biological_process	T-helper 17 cell differentiation
X	0160165	biological_process	CD8-positive, alpha-beta T cell homeostasis
X	1990111	cellular_component	spermatoproteasome complex
X	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
Y	0000502	cellular_component	proteasome complex
Y	0002376	biological_process	immune system process
Y	0005515	molecular_function	protein binding
Y	0005634	cellular_component	nucleus
Y	0005654	cellular_component	nucleoplasm
Y	0005737	cellular_component	cytoplasm
Y	0005829	cellular_component	cytosol
Y	0005839	cellular_component	proteasome core complex
Y	0006281	biological_process	DNA repair
Y	0006915	biological_process	apoptotic process
Y	0006974	biological_process	DNA damage response
Y	0006979	biological_process	response to oxidative stress
Y	0007283	biological_process	spermatogenesis
Y	0008021	cellular_component	synaptic vesicle
Y	0010498	biological_process	proteasomal protein catabolic process
Y	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
Y	0016020	cellular_component	membrane
Y	0019774	cellular_component	proteasome core complex, beta-subunit complex
Y	0030317	biological_process	flagellated sperm motility
Y	0032729	biological_process	positive regulation of type II interferon production
Y	0032743	biological_process	positive regulation of interleukin-2 production
Y	0032760	biological_process	positive regulation of tumor necrosis factor production
Y	0034341	biological_process	response to type II interferon
Y	0034515	cellular_component	proteasome storage granule
Y	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
Y	0043374	biological_process	CD8-positive, alpha-beta T cell differentiation
Y	0045061	biological_process	thymic T cell selection
Y	0045063	biological_process	T-helper 1 cell differentiation
Y	0045590	biological_process	negative regulation of regulatory T cell differentiation
Y	0051321	biological_process	meiotic cell cycle
Y	0051603	biological_process	proteolysis involved in protein catabolic process
Y	0061136	biological_process	regulation of proteasomal protein catabolic process
Y	0070062	cellular_component	extracellular exosome
Y	0071357	biological_process	cellular response to type I interferon
Y	0072539	biological_process	T-helper 17 cell differentiation
Y	0160165	biological_process	CD8-positive, alpha-beta T cell homeostasis
Y	1990111	cellular_component	spermatoproteasome complex
Y	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
Z	0004298	molecular_function	threonine-type endopeptidase activity
Z	0005839	cellular_component	proteasome core complex
Z	0051603	biological_process	proteolysis involved in protein catabolic process
a	0005839	cellular_component	proteasome core complex
a	0051603	biological_process	proteolysis involved in protein catabolic process
b	0005839	cellular_component	proteasome core complex
b	0051603	biological_process	proteolysis involved in protein catabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	Binding site for Ligand KNM H 300 bound to THR H 1

Chain	Residue
H	THR1
I	HIS116
I	SER118
H	THR20
H	THR21
H	THR22
H	LYS33
H	ARG45
H	GLY47
H	SER48
H	SER130

---

site_id	AC2
Number of Residues	11
Details	Binding site for Ligand KNM I 300 bound to THR I 1

Chain	Residue
I	THR1
I	ALA20
I	THR21
I	GLU22
I	ALA46
I	GLY47
I	ALA49
I	THR52
I	GLY128
I	SER129
J	ASP124

---

site_id	AC3
Number of Residues	9
Details	Binding site for Ligand KNM L 300 bound to THR L 1

Chain	Residue
L	THR1
L	ALA20
L	THR21
L	ALA22
L	LYS33
L	MET45
L	GLY47
L	ALA49
M	ASP125

---

site_id	AC4
Number of Residues	11
Details	Binding site for Ligand KNM V 300 bound to THR V 1

Chain	Residue
V	THR1
V	THR20
V	THR21
V	THR22
V	LYS33
V	ARG45
V	GLY47
V	SER48
V	SER130
W	HIS116
W	SER118

---

site_id	AC5
Number of Residues	11
Details	Binding site for Ligand KNM W 300 bound to THR W 1

Chain	Residue
W	THR1
W	ALA20
W	THR21
W	GLU22
W	ALA46
W	GLY47
W	ALA49
W	THR52
W	GLY128
W	SER129
X	ASP124

---

site_id	AC6
Number of Residues	9
Details	Binding site for Ligand KNM Z 300 bound to THR Z 1

Chain	Residue
Z	THR1
Z	ALA20
Z	THR21
Z	ALA22
Z	LYS33
Z	MET45
Z	GLY47
Z	ALA49
a	ASP125

---

Functional Information from PROSITE/UniProt

site_id	PS00388
Number of Residues	23
Details	PROTEASOME_ALPHA_1 Proteasome alpha-type subunits signature. YdrgvNtFSPeGRlfQVEYAieA

Chain	Residue	Details
E	TYR8-ALA30
A	PHE9-ALA31
B	TYR5-ALA27
G	TYR7-ALA29
D	TYR3-ALA25
C	TYR5-ALA27
F	TYR6-ALA28

---

site_id	PS00854
Number of Residues	48
Details	PROTEASOME_BETA_1 Proteasome beta-type subunits signature. AGVvYkdGIVLGADtrategmvvadkncs.KihfispniyccgaGtaAD

Chain	Residue	Details
I	ALA4-ASP51
J	MET11-ASP58
L	LEU4-ASP51
b	LEU12-ASP59
H	MET4-ASP51
a	LEU13-ASP60
K	ILE5-ASP52
C	LEU35-ASP82

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	16
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	20
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"Q9QUM9","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P49722","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"15592455","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P17220","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17323924","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	2
Details	Modified residue: {"description":"Phosphotyrosine; by ABL1 and ABL2","evidences":[{"source":"PubMed","id":"16678104","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	8
Details	Glycosylation: {"description":"O-linked (GlcNAc) serine","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"16964243","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine; alternate","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	2
Details	Glycosylation: {"description":"O-linked (GlcNAc) serine; alternate","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI18
Number of Residues	4
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)"}

Chain

Residue

Details

---

site_id	SWS_FT_FI19
Number of Residues	6
Details	Active site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"25599644","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27493187","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI20
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI21
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"18502982","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18565852","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19426847","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI22
Number of Residues	2
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"O09061","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---