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2IVU
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Crystal structure of phosphorylated RET tyrosine kinase domain complexed with the inhibitor ZD6474
分子名称: FORMIC ACID, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE RECEPTOR RET PRECURSOR, Vandetanib
著者Knowles, P.P, Murray-Rust, J, McDonald, N.Q.
登録日2006-06-16
公開日2006-08-10
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structure and chemical inhibition of the RET tyrosine kinase domain.
J. Biol. Chem., 281, 2006
3K6Z
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BU of 3k6z by Molmil
Crystal structure of Rv3671c protease, inactive form
分子名称: POSSIBLE MEMBRANE-ASSOCIATED SERINE PROTEASE
著者Biswas, T, Small, J, Vandal, O, Ehrt, S, Tsodikov, O.V.
登録日2009-10-10
公開日2010-10-13
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Structural insight into serine protease Rv3671c that Protects M. tuberculosis from oxidative and acidic stress.
Structure, 18, 2010
3A85
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Crystal Structure of Trypsin complexed with (E)-2-(4-carbamimidoylbenzylideneaminooxy)acetic acid (soaking 15 seconds)
分子名称: (E)-2-(4-carbamimidoylbenzylideneaminooxy)acetic acid, CALCIUM ION, Cationic trypsin, ...
著者Yamane, J, Yao, M, Tanaka, I.
登録日2009-10-05
公開日2010-09-29
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献In-Crystal Chemical Ligation for Drug Discovery
To be Published
2J3U
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L-ficolin complexed to galactose
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ...
著者Garlatti, V, Gaboriaud, C.
登録日2006-08-23
公開日2007-01-23
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Structural Insights Into the Innate Immune Recognition Specificities of L- and H-Ficolins.
Embo J., 26, 2007
2UZ5
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BU of 2uz5 by Molmil
Solution structure of the fkbp-domain of Legionella pneumophila Mip
分子名称: MACROPHAGE INFECTIVITY POTENTIATOR
著者Ceymann, A, Horstmann, M, Ehses, P, Schweimer, K, Steinert, M, Kamphausen, T, Fischer, G, Hacker, J, Rosch, P, Faber, C.
登録日2007-04-25
公開日2007-06-12
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献Domain Motions of the Mip Protein from Legionella Pneumophila
Biochemistry, 45, 2006
3JRT
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BU of 3jrt by Molmil
Structure from the mobile metagenome of V. paracholerae: Integron cassette protein Vpc_cass2
分子名称: Integron cassette protein Vpc_cass2
著者Harrop, S.J, Deshpande, C, Sureshan, V, Boucher, Y, Xu, X, Cui, H, Cuff, M, Edwards, A, Savchenko, A, Joachimiak, A, Stokes, H.W, Curmi, P.M.G, Mabbutt, B.C, Midwest Center for Structural Genomics (MCSG)
登録日2009-09-08
公開日2009-09-22
最終更新日2013-02-06
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Integron gene cassettes: a repository of novel protein folds with distinct interaction sites.
Plos One, 8, 2013
2UUB
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Structure of the Thermus thermophilus 30S ribosomal subunit complexed with a Valine-ASL with cmo5U in position 34 bound to an mRNA with a GUU-codon in the A-site and paromomycin.
分子名称: 16S Ribosomal RNA, 30S RIBOSOMAL PROTEIN S10, 30S RIBOSOMAL PROTEIN S11, ...
著者Weixlbaumer, A, Murphy, F.V, Dziergowska, A, Malkiewicz, A, Vendeix, F.A.P, Agris, P.F, Ramakrishnan, V.
登録日2007-03-01
公開日2007-05-15
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Mechanism for Expanding the Decoding Capacity of Transfer Rnas by Modification of Uridines
Nat.Struct.Mol.Biol., 14, 2007
3A4O
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Lyn kinase domain
分子名称: STAUROSPORINE, Tyrosine-protein kinase Lyn
著者Miyano, N, Kinoshita, T, Tada, T.
登録日2009-07-11
公開日2009-12-08
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Structural basis for the inhibitor recognition of human Lyn kinase domain
Bioorg.Med.Chem.Lett., 19, 2009
2IZ3
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Solution structure of human beta-microseminoprotein
分子名称: BETA-MICROSEMINOPROTEIN
著者Ghasriani, H, Teilum, K, Johnsson, Y, Fernlund, P, Drakenberg, T.
登録日2006-07-24
公開日2006-10-24
最終更新日2023-06-14
実験手法SOLUTION NMR
主引用文献Solution Structure of Human and Porcine Beta-Microseminoprotein
J.Mol.Biol., 362, 2006
3JTC
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Importance of Mg2+ in the Ca2+-Dependent Folding of the gamma-Carboxyglutamic Acid Domains of Vitamin K-Dependent clotting and anticlotting Proteins
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Endothelial protein C receptor, ...
著者Bajaj, S.P, Vadivel, K, Agah, S, Cascio, D, Krishnaswamy, S, Esmon, C, Padmanabhan, K.
登録日2009-09-11
公開日2011-04-06
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Structural and Functional Studies of gamma-Carboxyglutamic Acid Domains of Factor VIIa and Activated Protein C: Role of Magnesium at Physiological Calcium.
J.Mol.Biol., 425, 2013
3A80
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Crystal Structure of Trypsin complexed with (E)-2-(4-carbamimidoylbenzylideneaminooxy)-2-methylpropanoic acid (soaking 40seconds)
分子名称: (E)-2-(4-carbamimidoylbenzylideneaminooxy)-2-methylpropanoic acid, CALCIUM ION, Cationic trypsin
著者Yamane, J, Yao, M, Tanaka, I.
登録日2009-10-05
公開日2010-09-29
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献In-Crystal Chemical Ligation for Drug Discovery
To be Published
3A8C
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BU of 3a8c by Molmil
Crystal Structure of Trypsin complexed with (E)-2-(4-carbamimidoylbenzylideneaminooxy)acetic acid (soaking with mixture of [(E)-2-(4-carbamimidoylbenzylideneaminooxy)acetic acid] and [(E)-2-(4-carbamimidoylbenzylideneaminooxy)-2-methylpropanoic acid])
分子名称: (E)-2-(4-carbamimidoylbenzylideneaminooxy)acetic acid, CALCIUM ION, Cationic trypsin
著者Yamane, J, Yao, M, Tanaka, I.
登録日2009-10-05
公開日2010-09-29
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献In-Crystal Chemical Ligation for Drug Discovery
To be Published
2J9H
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Crystal structure of human glutathione-S-transferase P1-1 cys-free mutant in complex with S-hexylglutathione at 2.4 A resolution
分子名称: GLUTATHIONE S-TRANSFERASE P, S-HEXYLGLUTATHIONE
著者Tars, K, Hegazy, U.M, Hellman, U, Mannervik, B.
登録日2006-11-08
公開日2006-11-14
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Modulating Catalytic Activity by Unnatural Amino Acid Residues in a Gsh-Binding Loop of Gst P1-1.
J.Mol.Biol., 376, 2008
3KHV
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Crystal Structures of Urokinase-type Plasminogen Activator in Complex with 4-(Aminomethyl) Benzoic Acid and 4-(Aminomethyl-phenyl)-methanol
分子名称: SULFATE ION, TRIETHYLENE GLYCOL, Urokinase-type plasminogen activator, ...
著者Jiang, L.-G, Zhao, G.-X, Bian, X.-B, Yuan, C, Huang, Z.-X, Huang, M.-D.
登録日2009-10-30
公開日2009-12-01
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Crystal Structures of Urokinase-type Plasminogen Activator in Complex with 4-(Aminomethyl) Benzoic Acid and 4-(Aminomethyl-phenyl)-methanol
CHIN.J.STRUCT.CHEM., 28, 2009
2UUC
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BU of 2uuc by Molmil
Structure of the Thermus thermophilus 30S ribosomal subunit complexed with a Valine-ASL with cmo5U in position 34 bound to an mRNA with a GUA-codon in the A-site and paromomycin.
分子名称: 16S Ribosomal RNA, 30S RIBOSOMAL PROTEIN S10, 30S RIBOSOMAL PROTEIN S11, ...
著者Weixlbaumer, A, Murphy, F.V, Dziergowska, A, Malkiewicz, A, Vendeix, F.A.P, Agris, P.F, Ramakrishnan, V.
登録日2007-03-01
公開日2007-05-22
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Mechanism for expanding the decoding capacity of transfer RNAs by modification of uridines.
Nat. Struct. Mol. Biol., 14, 2007
3KJF
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Caspase 3 Bound to a covalent inhibitor
分子名称: (3S)-3-({[(5S,10aS)-2-{(2S)-4-carboxy-2-[(phenylacetyl)amino]butyl}-1,3-dioxo-2,3,5,7,8,9,10,10a-octahydro-1H-[1,2,4]triazolo[1,2-a]cinnolin-5-yl]carbonyl}amino)-4-oxopentanoic acid, Caspase-3
著者Kamtekar, S, Watt, W, Finzel, B.C, Harris, M.S, Blinn, J, Wang, Z, Tomasselli, A.G.
登録日2009-11-03
公開日2010-08-11
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Kinetic and structural characterization of caspase-3 and caspase-8 inhibition by a novel class of irreversible inhibitors.
Biochim.Biophys.Acta, 1804, 2010
2JA4
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Crystal structure of CD5 domain III reveals the fold of a group B scavenger cysteine-rich receptor
分子名称: T-CELL SURFACE GLYCOPROTEIN CD5
著者Rodamilans, B, Munoz, I.G, Sarrias, M.R, Lozano, F, Blanco, F.J, Montoya, G.
登録日2006-11-21
公開日2007-03-06
最終更新日2017-06-28
実験手法X-RAY DIFFRACTION (2.21 Å)
主引用文献Crystal Structure of the Third Extracellular Domain of Cd5 Reveals the Fold of a Group B Scavenger Cysteine-Rich Receptor Domain.
J.Biol.Chem., 282, 2007
3KJN
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Caspase 8 bound to a covalent inhibitor
分子名称: (3S)-3-({[(5S)-2-{2-[(1H-benzimidazol-5-ylcarbonyl)amino]ethyl}-7-(cyclohexylmethyl)-1,3-dioxo-2,3,5,8-tetrahydro-1H-[1,2,4]triazolo[1,2-a]pyridazin-5-yl]carbonyl}amino)-4-oxopentanoic acid, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, Caspase-8
著者Kamtekar, S, Watt, W, Finzel, B.C, Harris, M.S, Blinn, J, Wang, Z, Tomasselli, A.G.
登録日2009-11-03
公開日2010-08-11
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Kinetic and structural characterization of caspase-3 and caspase-8 inhibition by a novel class of irreversible inhibitors.
Biochim.Biophys.Acta, 1804, 2010
2JCC
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BU of 2jcc by Molmil
AH3 recognition of mutant HLA-A2 W167A
分子名称: BETA-2-MICROGLOBULIN, HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, A-2 ALPHA CHAIN, ...
著者Miller, P, Benhar, Y.P, Biddison, W, Collins, E.J.
登録日2006-12-21
公開日2007-10-09
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Single Mhc Mutation Eliminates Enthalpy Associated with T Cell Receptor Binding.
J.Mol.Biol., 373, 2007
3KID
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BU of 3kid by Molmil
The Crystal Structures of 2-Aminobenzothiazole-based Inhibitors in Complexes with Urokinase-type Plasminogen Activator
分子名称: Urokinase-type plasminogen activator, ethyl 2-amino-1,3-benzothiazole-6-carboxylate
著者Jiang, L.-G, Yu, H.Y, Yuan, C, Wang, J.D, Chen, L.Q, Meehan, E.J, Huang, Z.-X, Huang, M.-D.
登録日2009-11-01
公開日2009-12-01
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.71 Å)
主引用文献Crystal Structures of 2-Aminobenzothiazole-based Inhibitors in Complexes with Urokinase-type Plasminogen Activator
CHIN.J.STRUCT.CHEM., 28, 2009
2JHH
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Structure of globular heads of M-ficolin at acidic pH
分子名称: CALCIUM ION, FICOLIN-1
著者Garlatti, V, Martin, L, Gout, E, Reiser, J.B, Arlaud, G.J, Thielens, N.M, Gaboriaud, C.
登録日2007-02-22
公開日2007-10-09
最終更新日2019-04-03
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Structural basis for innate immune sensing by M-ficolin and its control by a pH-dependent conformational switch.
J. Biol. Chem., 282, 2007
3A7X
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BU of 3a7x by Molmil
Crystal Structure of Trypsin complexed with (E)-2-(4-carbamimidoylbenzylideneaminooxy)acetic acid (soaking 45seconds)
分子名称: (E)-2-(4-carbamimidoylbenzylideneaminooxy)acetic acid, CALCIUM ION, Cationic trypsin, ...
著者Yamane, J, Yao, M, Tanaka, I.
登録日2009-10-05
公開日2010-09-29
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献In-Crystal Chemical Ligation for Drug Discovery
To be Published
3A86
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Crystal Structure of Trypsin complexed with (E)-2-(4-carbamimidoylbenzylideneaminooxy)acetic acid (soaking 30 seconds)
分子名称: (E)-2-(4-carbamimidoylbenzylideneaminooxy)acetic acid, CALCIUM ION, Cationic trypsin, ...
著者Yamane, J, Yao, M, Tanaka, I.
登録日2009-10-05
公開日2010-09-29
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献In-Crystal Chemical Ligation for Drug Discovery
To be Published
2V00
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X-ray crystal structure of endothiapepsin complexed with compound 1
分子名称: 2-AMINO-6-(2-PHENYLETHYL)PYRIMIDIN-4(3H)-ONE, ACETATE ION, ENDOTHIAPEPSIN, ...
著者Geschwindner, S, Olsson, L.L, Deinum, J, Albert, J.S, Edwards, P.D, De Beer, T, Folmer, R.H.A.
登録日2007-05-03
公開日2007-12-04
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献Discovery of a Novel Warhead Against Beta-Secretase Through Fragment-Based Lead Generation.
J.Med.Chem., 50, 2007
2JRI
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Solution structure of the Josephin domain of Ataxin-3 in complex with ubiquitin molecule.
分子名称: Ataxin-3, UBC protein
著者Nicastro, G, Masino, L, Esposito, V, Menon, R, Pastore, A.
登録日2007-06-27
公開日2008-07-01
最終更新日2024-05-29
実験手法SOLUTION NMR
主引用文献Understanding the plasticity of the ubiquitin-protein recognition code: the josephin domain of ataxin-3 is a diubiquitin binding motif
To be Published

223790

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