Solution structure of the Josephin domain of Ataxin-3 in complex with ubiquitin molecule.

Summary for 2JRI

DescriptorAtaxin-3, UBC protein (2 entities in total)
Functional Keywordsdi-ubiquitin, lys48-linked, josephin domain of ataxin-3, spinocerebellar ataxia type 3 protein, alternative splicing, hydrolase, neurodegeneration, nucleus, phosphorylation, polymorphism, transcription, transcription regulation, triplet repeat expansion, hydrolase-signaling protein complex, hydrolase/signaling protein
Biological sourceHomo sapiens (human)
Cellular locationNucleus matrix P54252
Total number of polymer chains3
Total molecular weight38207.43
Nicastro, G.,Masino, L.,Esposito, V.,Menon, R.,Pastore, A. (deposition date: 2007-06-27, release date: 2008-07-01, Last modification date: 2011-07-13)
Primary citation
Nicastro, G.,Menon, R.,Masino, L.,Pastore, A.
Understanding the plasticity of the ubiquitin-protein recognition code: the josephin domain of ataxin-3 is a diubiquitin binding motif
To be Published,
Experimental method
NMR Information

Structure validation

ClashscoreRamachandran outliersSidechain outliers41.8%14.1%MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all NMR structures
Download full validation report