6SVF
 
 | | Crystal structure of the P235GK mutant of ArgBP from T. maritima | | 分子名称: | ARGININE, Amino acid ABC transporter, periplasmic amino acid-binding protein | | 著者 | Vitagliano, L, Berisio, R, Esposito, L, Balasco, N, Smaldone, G, Ruggiero, A. | | 登録日 | 2019-09-18 | | 公開日 | 2019-11-20 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | The non-swapped monomeric structure of the arginine-binding protein from Thermotoga maritima.
Acta Crystallogr.,Sect.F, 75, 2019
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6VO0
 | | BG505 SOSIP.v5.2 in complex with rabbit Fab 43A2 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 43A2 heavy chain, ... | | 著者 | Nogal, B, Cottrell, C.A, Ward, A.B. | | 登録日 | 2020-01-29 | | 公開日 | 2020-07-01 | | 最終更新日 | 2020-07-29 | | 実験手法 | ELECTRON MICROSCOPY (3.52 Å) | | 主引用文献 | HIV envelope trimer-elicited autologous neutralizing antibodies bind a region overlapping the N332 glycan supersite.
Sci Adv, 6, 2020
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1BVH
 | | SOLUTION STRUCTURE OF A LOW MOLECULAR WEIGHT PROTEIN TYROSINE PHOSPHATASE | | 分子名称: | ACID PHOSPHATASE | | 著者 | Logan, T.M, Zhou, M.-M, Nettesheim, D.G, Meadows, R.P, Van Etten, R.L, Fesik, S.W. | | 登録日 | 1994-05-03 | | 公開日 | 1994-07-31 | | 最終更新日 | 2024-05-22 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution structure of a low molecular weight protein tyrosine phosphatase.
Biochemistry, 33, 1994
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6X0P
 | | Ash1L SET domain Q2265A mutant in complex with AS-5 | | 分子名称: | 3-[6-(aminomethyl)-1-(2-hydroxyethyl)-1H-indol-3-yl]benzene-1-carbothioamide, Histone-lysine N-methyltransferase ASH1L, S-ADENOSYLMETHIONINE, ... | | 著者 | Rogawski, D.S, Li, H, Borkin, D, Cierpicki, T, Grembecka, J. | | 登録日 | 2020-05-17 | | 公開日 | 2021-04-07 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.69 Å) | | 主引用文献 | Discovery of first-in-class inhibitors of ASH1L histone methyltransferase with anti-leukemic activity.
Nat Commun, 12, 2021
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6XWY
 | | Highly pH-resistant long stokes-shift, red fluorescent protein mCRISPRed | | 分子名称: | 1,2-ETHANEDIOL, MALONIC ACID, Red fluorescent protein eqFP611 | | 著者 | Erdogan, M, Fabritius, A, Basquin, J, Griesbeck, O. | | 登録日 | 2020-01-24 | | 公開日 | 2020-02-05 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Targeted In Situ Protein Diversification and Intra-organelle Validation in Mammalian Cells.
Cell Chem Biol, 27, 2020
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4YER
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4YU4
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7BRI
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7BRJ
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7BRG
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7BRH
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7BRL
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7BRK
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6ATT
 | | 39S Fab bound to HER2 ecd | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Antibody 39S Fab heavy chain, ... | | 著者 | Oganesyan, V.Y, Dall'Acqua, W.F. | | 登録日 | 2017-08-29 | | 公開日 | 2018-04-25 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (3.77 Å) | | 主引用文献 | Structural insights into the mechanism of action of a biparatopic anti-HER2 antibody.
J. Biol. Chem., 293, 2018
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4YU3
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6KIK
 | | Crystal structure of a thermostable aldo-keto reductase Tm1743 in complex with inhibitor tolrestat | | 分子名称: | Oxidoreductase, aldo/keto reductase family, TOLRESTAT | | 著者 | Zhang, C.Y, Liu, X.M, Wang, C, Tang, W.R. | | 登録日 | 2019-07-18 | | 公開日 | 2019-09-25 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.601 Å) | | 主引用文献 | Tolrestat acts atypically as a competitive inhibitor of the thermostable aldo-keto reductase Tm1743 from Thermotoga maritima.
Febs Lett., 594, 2020
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6KIY
 | | Crystal structure of a thermostable aldo-keto reductase Tm1743 in complex with inhibitor Epalrestat | | 分子名称: | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Oxidoreductase, aldo/keto reductase family, ... | | 著者 | Zhang, C.Y, Liu, X.M, Wang, C, Min, Z.Z, Xu, X.L. | | 登録日 | 2019-07-20 | | 公開日 | 2019-09-25 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Tolrestat acts atypically as a competitive inhibitor of the thermostable aldo-keto reductase Tm1743 from Thermotoga maritima.
Febs Lett., 594, 2020
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6KY6
 | | Crystal structure of a thermostable aldo-keto reductase Tm1743 in complexs with inhibitor epalrestat in space group P3221cc | | 分子名称: | 2,5-diketo-D-gluconic acid reductase, CHLORIDE ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | | 著者 | Zhang, C.Y, Min, Z.Z, Liu, X.M, Wang, C, Tang, W.R. | | 登録日 | 2019-09-16 | | 公開日 | 2019-10-02 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.07 Å) | | 主引用文献 | Tolrestat acts atypically as a competitive inhibitor of the thermostable aldo-keto reductase Tm1743 from Thermotoga maritima.
Febs Lett., 594, 2020
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2LD6
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6E6Y
 | | Dieckmann cyclase, NcmC | | 分子名称: | Dieckmann cyclase, NcmC, SULFATE ION | | 著者 | Cogan, D.P, Nair, S.K. | | 登録日 | 2018-07-25 | | 公開日 | 2019-07-31 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Structural Basis for Enzymatic Off-Loading of Hybrid Polyketides by Dieckmann Condensation.
Acs Chem.Biol., 2020
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8IYU
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7VC1
 | | Toxoplasma gondii Prolyl-tRNA Synthetase (TgPRS) in Complex with inhibitor L95 and L-proline in space group P21 | | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, GLYCEROL, ... | | 著者 | Yogavel, M, Malhotra, N, Sharma, A. | | 登録日 | 2021-09-01 | | 公開日 | 2022-09-07 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.892 Å) | | 主引用文献 | Targeting prolyl-tRNA synthetase via a series of ATP-mimetics to accelerate drug discovery against toxoplasmosis.
Plos Pathog., 19, 2023
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7VC2
 | | Toxoplasma gondii Prolyl-tRNA Synthetase (TgPRS) in Complex with inhibitor L96 and L-proline in space group P21 | | 分子名称: | 1,2-ETHANEDIOL, 4-[(3S)-3-cyano-3-cyclopropyl-2-oxidanylidene-pyrrolidin-1-yl]-N-[[3-fluoranyl-5-(5-methoxypyridin-3-yl)phenyl]methyl]-6-methyl-pyridine-2-carboxamide, CHLORIDE ION, ... | | 著者 | Yogavel, M, Malhotra, N, Sharma, A. | | 登録日 | 2021-09-01 | | 公開日 | 2022-09-07 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.096 Å) | | 主引用文献 | Targeting prolyl-tRNA synthetase via a series of ATP-mimetics to accelerate drug discovery against toxoplasmosis.
Plos Pathog., 19, 2023
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7EFZ
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4OVL
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