6KIY

Crystal structure of a thermostable aldo-keto reductase Tm1743 in complex with inhibitor Epalrestat

Summary for 6KIY

Entry DOI	10.2210/pdb6kiy/pdb
Related	6KIK
Descriptor	Oxidoreductase, aldo/keto reductase family, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, {5-[(2E)-2-methyl-3-phenylprop-2-en-1-ylidene]-4-oxo-2-thioxo-1,3-thiazolidin-3-yl}acetic acid, ... (4 entities in total)
Functional Keywords	aldo-ketone reductase, epalrestat, competitive inhibitor, nadph, oxidoreductase
Biological source	Thermotoga maritima MSB8
Total number of polymer chains	1
Total formula weight	32552.83
Authors	Zhang, C.Y.,Liu, X.M.,Wang, C.,Min, Z.Z.,Xu, X.L. (deposition date: 2019-07-20, release date: 2019-09-25, Last modification date: 2023-11-22)
Primary citation	Zhang, C.,Min, Z.,Liu, X.,Wang, C.,Wang, Z.,Shen, J.,Tang, W.,Zhang, X.,Liu, D.,Xu, X. Tolrestat acts atypically as a competitive inhibitor of the thermostable aldo-keto reductase Tm1743 from Thermotoga maritima. Febs Lett., 594:564-580, 2020 Cited by PubMed: 31573681 DOI: 10.1002/1873-3468.13630 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation