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6KIY

Crystal structure of a thermostable aldo-keto reductase Tm1743 in complex with inhibitor Epalrestat

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0016491molecular_functionoxidoreductase activity
Functional Information from PDB Data
site_idAC1
Number of Residues28
Detailsbinding site for residue NAP A 301
ChainResidue
AGLY19
ATYR198
ASER199
APRO200
ALEU201
AARG202
AARG203
ATHR204
ATYR226
AILE242
APRO243
ATHR20
ALYS244
AALA245
AGLY246
AARG247
AHIS250
AGLU253
AASN254
AEPR302
AHOH404
ATRP21
AASP53
ATYR58
AHIS117
ASER147
AASN148
AGLN169

site_idAC2
Number of Residues6
Detailsbinding site for residue EPR A 302
ChainResidue
ATYR58
AHIS117
AARG203
ANAP301
AHOH401
AHOH452

Functional Information from PROSITE/UniProt
site_idPS00062
Number of Residues18
DetailsALDOKETO_REDUCTASE_2 Aldo/keto reductase family signature 2. MaegvrqglIRYIGVSNF
ChainResidueDetails
AMET132-PHE149

226707

PDB entries from 2024-10-30

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