PDB: 957 件ウェブページステータス検索Chemie searchBIRD

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4MNE	Crystal structure of the BRAF:MEK1 complex 分子名称: 7-fluoro-3-[(2-fluoro-4-iodophenyl)amino]-N-{[(2S)-2-hydroxypropyl]oxy}furo[3,2-c]pyridine-2-carboxamide, CHLORIDE ION, Dual specificity mitogen-activated protein kinase kinase 1, ... 著者 Sudhamsu, J, Haling, J.R, Morales, T, Brandhuber, B, Hymowitz, S.G. 登録日 2013-09-10 公開日 2014-06-18 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.8483 Å) 主引用文献 Structure of the BRAF-MEK Complex Reveals a Kinase Activity Independent Role for BRAF in MAPK Signaling. Cancer Cell, 26, 2014
4LQW	Crystal structure of HIV-1 capsid N-terminal domain in complex with NUP358 cyclophilin 分子名称: Capsid protein p24, E3 SUMO-protein ligase RanBP2 著者 Price, A.J, James, L.C. 登録日 2013-07-19 公開日 2013-08-14 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 HIV-1 capsid undergoes coupled binding and isomerization by the nuclear pore protein NUP358. Retrovirology, 10, 2013
4LOQ	Structural basis of autoactivation of p38 alpha induced by TAB1 (Tetragonal crystal form with bound sulphate) 分子名称: 1,2-ETHANEDIOL, 4-(4-FLUOROPHENYL)-1-(4-PIPERIDINYL)-5-(2-AMINO-4-PYRIMIDINYL)-IMIDAZOLE, Mitogen-activated protein kinase 14, ... 著者 Chaikuad, A, DeNicola, G.F, Yue, W.W, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Marber, M.S, Knapp, S, Structural Genomics Consortium (SGC) 登録日 2013-07-13 公開日 2013-08-21 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.319 Å) 主引用文献 Mechanism and consequence of the autoactivation of p38 alpha mitogen-activated protein kinase promoted by TAB1. Nat.Struct.Mol.Biol., 20, 2013
4LOP	Structural basis of autoactivation of p38 alpha induced by TAB1 (Tetragonal crystal form) 分子名称: 1,2-ETHANEDIOL, 4-(4-FLUOROPHENYL)-1-(4-PIPERIDINYL)-5-(2-AMINO-4-PYRIMIDINYL)-IMIDAZOLE, L(+)-TARTARIC ACID, ... 著者 Chaikuad, A, DeNicola, G.F, Krojer, T, Allerston, C.K, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Marber, M.S, Knapp, S, Structural Genomics Consortium (SGC) 登録日 2013-07-13 公開日 2013-08-21 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.049 Å) 主引用文献 Mechanism and consequence of the autoactivation of p38 alpha mitogen-activated protein kinase promoted by TAB1. Nat.Struct.Mol.Biol., 20, 2013
4LOO	Structural basis of autoactivation of p38 alpha induced by TAB1 (Monoclinic crystal form) 分子名称: 4-(4-FLUOROPHENYL)-1-(4-PIPERIDINYL)-5-(2-AMINO-4-PYRIMIDINYL)-IMIDAZOLE, Mitogen-activated protein kinase 14, TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 著者 Chaikuad, A, DeNicola, G.F, Krojer, T, Allerston, C.K, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Marber, M.S, Knapp, S, Structural Genomics Consortium (SGC) 登録日 2013-07-13 公開日 2013-08-21 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Mechanism and consequence of the autoactivation of p38 alpha mitogen-activated protein kinase promoted by TAB1. Nat.Struct.Mol.Biol., 20, 2013
4LMN	Crystal Structure of MEK1 kinase bound to GDC0973 分子名称: Dual specificity mitogen-activated protein kinase kinase 1, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... 著者 Ultsch, M.H. 登録日 2013-07-10 公開日 2013-08-07 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Mechanism of MEK inhibition determines efficacy in mutant KRAS- versus BRAF-driven cancers. Nature, 501, 2013
4L8M	Human p38 MAP kinase in complex with a Dibenzoxepinone 分子名称: Mitogen-activated protein kinase 14, N-[2-fluoro-5-({9-[2-(morpholin-4-yl)ethoxy]-11-oxo-6,11-dihydrodibenzo[b,e]oxepin-3-yl}amino)phenyl]benzamide, octyl beta-D-glucopyranoside 著者 Richters, A, Mayer-Wrangowski, S.C, Gruetter, C, Rauh, D. 登録日 2013-06-17 公開日 2013-10-30 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Metabolically Stable Dibenzo[b,e]oxepin-11(6H)-ones as Highly Selective p38 MAP Kinase Inhibitors: Optimizing Anti-Cytokine Activity in Human Whole Blood. J.Med.Chem., 56, 2013
4KKH	The crystal structure of inhibitor-bound JNK3 分子名称: Mitogen-activated protein kinase 10, cyclopropyl[(3R)-3-({4-[6-hydroxy-2-(naphthalen-2-yl)-1H-benzimidazol-1-yl]pyrimidin-2-yl}amino)piperidin-1-yl]methanone 著者 Han, B.G, Shim, M.B, Ahn, H.C. 登録日 2013-05-06 公開日 2014-05-21 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 The crystal structure of AMP, apo, and inhibitor-bound JNK3 To be Published
4KKG	Crystal structure of apo and AMP-bound JNK3 分子名称: Mitogen-activated protein kinase 10 著者 Han, B.G, Shim, M.B, Ahn, H.C. 登録日 2013-05-06 公開日 2014-05-21 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 crystal structure of apo and AMP-bound JNK3 To be Published
4KKE	The crystal structure of AMP-bound JNK3 分子名称: ADENOSINE MONOPHOSPHATE, Mitogen-activated protein kinase 10 著者 Han, B.G, Shim, M.B, Ahn, H.C. 登録日 2013-05-06 公開日 2014-05-21 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 The crystal structure of AMP-bound JNK3 To be Published
4KIQ	Crystal structure of mitogen-activated protein kinase 14 (P38-H5) complex with ETHYL 6-((5-(CYCLOPROPYLCARBAMOYL)-2-METHYLPHENYL)CARBAMOYL)-1H-INDOLE-1-CARBOXYLATE 分子名称: Mitogen-activated protein kinase 14, ethyl 6-{[5-(cyclopropylcarbamoyl)-2-methylphenyl]carbamoyl}-1H-indole-1-carboxylate 著者 Sack, J.S, Tokarski, J.S. 登録日 2013-05-02 公開日 2013-06-12 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 The Identification of Novel P38-Alpha Isoform Selective Kinase Inhibitors Having an Unprecedented P38-Alpha Binding Mode Bioorg.Med.Chem.Lett., 23, 2013
4KIP	Crystal structure of mitogen-activated protein kinase 14 (P38-H5) complex with 2-(2-CHLOROPHENYL)-N-(5-(CYCLOPROPYLCARBAMOYL)-2-METHYLPHENYL)-1,3-THIAZOLE-5-CARBOXAMIDE 分子名称: 2-(2-chlorophenyl)-N-[5-(cyclopropylcarbamoyl)-2-methylphenyl]-1,3-thiazole-5-carboxamide, Mitogen-activated protein kinase 14 著者 Sack, J.S, Tokarski, J.S. 登録日 2013-05-02 公開日 2013-06-12 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.27 Å) 主引用文献 The Identification of Novel P38-Alpha Isoform Selective Kinase Inhibitors Having an Unprecedented P38-Alpha Binding Mode Bioorg.Med.Chem.Lett., 23, 2013
4KIN	Crystal structure of mitogen-activated protein kinase 14 (P38-H5) complex with 5-(2-CHLOROPHENYL)-N-(5-(CYCLOPROPYLCARBAMOYL)-2-METHYLPHENYL)-2-THIOPHENECARBOXAMIDE 分子名称: 5-(2-chlorophenyl)-N-[5-(cyclopropylcarbamoyl)-2-methylphenyl]thiophene-2-carboxamide, Mitogen-activated protein kinase 14 著者 Sack, J.S, Tokarski, J.S. 登録日 2013-05-02 公開日 2013-06-12 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.97 Å) 主引用文献 The Identification of Novel P38-Alpha Isoform Selective Kinase Inhibitors Having an Unprecedented P38-Alpha Binding Mode Bioorg.Med.Chem.Lett., 23, 2013
4KA3	Structure of MAP kinase in complex with a docking peptide 分子名称: Mitogen-activated protein kinase 14, TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 著者 Xin, F.J, Wu, J.W. 登録日 2013-04-22 公開日 2013-06-26 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.707 Å) 主引用文献 Crystal structure of the p38 alpha MAP kinase in complex with a docking peptide from TAB1 Sci China Life Sci, 56, 2013
4IZA	Structure of Dually Phosphorylated ERK2 bound to the PEA-15 Death Effector Domain 分子名称: Astrocytic phosphoprotein PEA-15, Mitogen-activated protein kinase 1 著者 Mace, P.D, Robinson, H, Riedl, S.J. 登録日 2013-01-29 公開日 2013-04-10 最終更新日 2013-04-24 実験手法 X-RAY DIFFRACTION (1.93 Å) 主引用文献 Structure of ERK2 bound to PEA-15 reveals a mechanism for rapid release of activated MAPK. Nat Commun, 4, 2013
4IZ7	Structure of Non-Phosphorylated ERK2 bound to the PEA-15 Death Effector Domain 分子名称: Astrocytic phosphoprotein PEA-15, Mitogen-activated protein kinase 1, SODIUM ION 著者 Mace, P.D, Robinson, H, Riedl, S.J. 登録日 2013-01-29 公開日 2013-04-10 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structure of ERK2 bound to PEA-15 reveals a mechanism for rapid release of activated MAPK. Nat Commun, 4, 2013
4IZ5	Structure of the complex between ERK2 phosphomimetic mutant and PEA-15 分子名称: ADENOSINE-5'-DIPHOSPHATE, Astrocytic phosphoprotein PEA-15, Mitogen-activated protein kinase 1, ... 著者 Mace, P.D, Robinson, H, Riedl, S.J. 登録日 2013-01-29 公開日 2013-04-10 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (3.19 Å) 主引用文献 Structure of ERK2 bound to PEA-15 reveals a mechanism for rapid release of activated MAPK. Nat Commun, 4, 2013
4I5H	Crystal Structure of a Double Mutant Rat Erk2 Complexed With a Type II Quinazoline Inhibitor 分子名称: Mitogen-activated protein kinase 1, N-{3-[2-(cyclopropylamino)quinazolin-6-yl]-4-methylphenyl}-3-(trifluoromethyl)benzamide 著者 Hari, S.B, Maly, D.J, Merritt, E.A. 登録日 2012-11-28 公開日 2013-07-10 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Sequence determinants of a specific inactive protein kinase conformation. Chem.Biol., 20, 2013
4H3Q	Crystal structure of human ERK2 complexed with a MAPK docking peptide 分子名称: Dual specificity mitogen-activated protein kinase kinase 2, Mitogen-activated protein kinase 1, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER 著者 Gogl, G, Toeroe, I, Remenyi, A. 登録日 2012-09-14 公開日 2013-02-27 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Protein-peptide complex crystallization: a case study on the ERK2 mitogen-activated protein kinase Acta Crystallogr.,Sect.D, 69, 2013
4H3P	Crystal structure of human ERK2 complexed with a MAPK docking peptide 分子名称: Mitogen-activated protein kinase 1, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Ribosomal protein S6 kinase alpha-1 著者 Gogl, G, Toeroe, I, Remenyi, A. 登録日 2012-09-14 公開日 2013-02-27 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Protein-peptide complex crystallization: a case study on the ERK2 mitogen-activated protein kinase Acta Crystallogr.,Sect.D, 69, 2013
4H3B	Crystal Structure of JNK3 in Complex with SAB Peptide 分子名称: Mitogen-activated protein kinase 10, SH3 domain-binding protein 5 著者 Nwachukwu, J.C, Laughlin, J.D, Figuera-Losada, M, Cherry, L, Nettles, K.W, LoGrasso, P.V. 登録日 2012-09-13 公開日 2012-11-21 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.08 Å) 主引用文献 Structural Mechanisms of Allostery and Autoinhibition in JNK Family Kinases. Structure, 20, 2012
4H39	Crystal Structure of JNK3 in Complex with JIP1 Peptide 分子名称: C-Jun-amino-terminal kinase-interacting protein 1, Mitogen-activated protein kinase 10 著者 Nwachukwu, J.C, Laughlin, J.D, Figuera-Losada, M, Cherry, L, Nettles, K.W, LoGrasso, P.V. 登録日 2012-09-13 公開日 2012-11-21 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.992 Å) 主引用文献 Structural Mechanisms of Allostery and Autoinhibition in JNK Family Kinases. Structure, 20, 2012
4H36	Crystal Structure of JNK3 in Complex with ATF2 Peptide 分子名称: Cyclic AMP-dependent transcription factor ATF-2, Mitogen-activated protein kinase 10 著者 Nwachukwu, J.C, Laughlin, J.D, Figuera-Losada, M, Cherry, L, Nettles, K.W, LoGrasso, P.V. 登録日 2012-09-13 公開日 2012-11-21 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Structural Mechanisms of Allostery and Autoinhibition in JNK Family Kinases. Structure, 20, 2012
4GVA	ADP-bound form of the ERK2 kinase 分子名称: ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, Mitogen-activated protein kinase 1 著者 Pozharski, E, Zhang, J, Shapiro, P. 登録日 2012-08-30 公開日 2012-09-12 実験手法 X-RAY DIFFRACTION (1.83 Å) 主引用文献 ADP-bound form of the ERK2 kinase TO BE PUBLISHED
4GT3	ATP-bound form of the ERK2 kinase 分子名称: ADENOSINE-5'-TRIPHOSPHATE, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... 著者 Pozharski, E, Zhang, J, Shapiro, P. 登録日 2012-08-28 公開日 2012-09-12 実験手法 X-RAY DIFFRACTION (1.68 Å) 主引用文献 ATP-bound form of the ERK2 kinase TO BE PUBLISHED

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