PDB: 8717 件ウェブページステータス検索Chemie searchBIRD

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4POL	Crystal structures of thioredoxin with mesna at 2.8A resolution 分子名称: 1-THIOETHANESULFONIC ACID, Thioredoxin 著者 Sridhar, V, Chie-Leon, B, Badger, J, Nienaber, V.L, Hausheer, F.H. 登録日 2014-02-26 公開日 2014-10-29 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 BNP7787 Forms Novel Covalent Adducts on Human Thioredoxin and Modulates Thioredoxin Activity J Pharmacol Clin Toxicol, 2, 2014
8D7I	Bifunctional Inhibition of Neutrophil Elastase and Cathepsin G by Eap1 from S. aureus 分子名称: Cathepsin G, C-terminal truncated form, Extracellular Adherence Protein, ... 著者 Gido, C.D, Herdendorf, T.J, Geisbrecht, B.V. 登録日 2022-06-07 公開日 2023-06-14 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (3.63 Å) 主引用文献 Bifunctional Inhibition of Neutrophil Elastase and Cathepsin G by Eap1 from S. aureus To Be Published
4WVP	Crystal structure of an activity-based probe HNE complex 分子名称: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, BTN-3V3-NLB-OMT-OIC-3V2, ... 著者 Lechtenberg, B.C, Kasperkiewicz, P, Robinson, H.R, Drag, M, Riedl, S.J. 登録日 2014-11-06 公開日 2015-02-11 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.63 Å) 主引用文献 The Elastase-PK101 Structure: Mechanism of an Ultrasensitive Activity-based Probe Revealed. Acs Chem.Biol., 10, 2015
8DYG	IL17A homodimer bound to Compound 7 分子名称: (5P)-2-hydroxy-5-(6-methylquinolin-5-yl)benzoic acid, Interleukin-17A 著者 Argiriadi, M.A, Goedken, E.R. 登録日 2022-08-04 公開日 2022-09-07 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.49 Å) 主引用文献 Identification and structure-based drug design of cell-active inhibitors of interleukin 17A at a novel C-terminal site. Sci Rep, 12, 2022
8DYH	IL17A homodimer bound to Compound 6 分子名称: (5P)-N-benzyl-6-chloro-5-(quinolin-5-yl)pyridin-3-amine, GLYCEROL, Interleukin-17A 著者 Argiriadi, M.A, Goedken, E.R. 登録日 2022-08-04 公開日 2022-09-07 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.94 Å) 主引用文献 Identification and structure-based drug design of cell-active inhibitors of interleukin 17A at a novel C-terminal site. Sci Rep, 12, 2022
8DYF	IL17A homodimer bound to Compound 10 分子名称: (5M)-3-[({2-[2-(2-{2-[2-({[(5M)-3-carboxy-5-(5,8-dihydroquinolin-4-yl)phenyl]amino}methyl)phenoxy]ethoxy}ethoxy)ethoxy]phenyl}methyl)amino]-5-(quinolin-4-yl)benzoic acid, Interleukin-17A 著者 Argiriadi, M.A, Goedken, E.R. 登録日 2022-08-04 公開日 2022-09-07 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.02 Å) 主引用文献 Identification and structure-based drug design of cell-active inhibitors of interleukin 17A at a novel C-terminal site. Sci Rep, 12, 2022
8DYI	IL17A homodimer bound to Compound 5 分子名称: (5P)-5-[5-(benzylamino)pyridin-3-yl]-N-[2-(morpholin-4-yl)ethyl]-1H-indazol-3-amine, Interleukin-17A 著者 Argiriadi, M.A, Goedken, E.R. 登録日 2022-08-04 公開日 2022-09-07 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.28 Å) 主引用文献 Identification and structure-based drug design of cell-active inhibitors of interleukin 17A at a novel C-terminal site. Sci Rep, 12, 2022
8DY5	Crystal Structure of spFv CAT2200 LH in complex with IL-17A 分子名称: CALCIUM ION, CHLORIDE ION, Interleukin-17A, ... 著者 Luo, J, Boucher, L.E. 登録日 2022-08-03 公開日 2023-05-03 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 "Stapling" scFv for multispecific biotherapeutics of superior properties. Mabs, 15, 2023
8DY1	Crystal Structure of scFv CAT2200 LH in complex with IL-17A 分子名称: Interleukin-17A, SULFATE ION, scFv CAT2200 LH 著者 Luo, J, Armstrong, A.A. 登録日 2022-08-03 公開日 2023-05-03 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.68 Å) 主引用文献 "Stapling" scFv for multispecific biotherapeutics of superior properties. Mabs, 15, 2023
8E3R	Human PU.1 ETS-Domain (165-270) Bound to d(AATAAAAGGAAGTGGG) 分子名称: DNA (5'-D(*AP*AP*TP*AP*AP*AP*AP*GP*GP*AP*AP*GP*TP*GP*GP*G)-3'), DNA (5'-D(*TP*CP*CP*CP*AP*CP*TP*TP*CP*CP*TP*TP*TP*TP*AP*T)-3'), Transcription factor PU.1 著者 Terrell, J.R, Poon, G.M.K. 登録日 2022-08-17 公開日 2023-07-05 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 DNA selection by the master transcription factor PU.1. Cell Rep, 42, 2023
4OO5	Crystal Structure of S-nitrosated Human Thioredoxin Mutant 分子名称: Thioredoxin 著者 The, J, Weichsel, A, Montfort, W.R. 登録日 2014-01-30 公開日 2014-02-12 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.54 Å) 主引用文献 Crystal Structure of a Thioredoxin Mutant Displays a Dynamic N-terminal Loop Surrounding an S-nitrosation Site To be Published
1MDM	INHIBITED FRAGMENT OF ETS-1 AND PAIRED DOMAIN OF PAX5 BOUND TO DNA 分子名称: C-ETS-1 PROTEIN, PAIRED BOX PROTEIN PAX-5, PAX5/ETS BINDING SITE ON THE MB-1 PROMOTER 著者 Garvie, C.W, Pufall, M.A, Graves, B.J, Wolberger, C. 登録日 2002-08-07 公開日 2002-12-11 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 STRUCTURAL ANALYSIS OF THE AUTOINHIBITION OF ETS-1 AND ITS ROLE IN PROTEIN PARTNERSHIPS J.Biol.Chem., 277, 2002
5LGD	The CIDRa domain from MCvar1 PfEMP1 bound to CD36 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, ... 著者 Hsieh, F.L, Higgins, M.K. 登録日 2016-07-06 公開日 2016-08-31 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.07 Å) 主引用文献 The structural basis for CD36 binding by the malaria parasite. Nat Commun, 7, 2016
4POK	Crystal structures of thioredoxin with mesna at 2.5A resolution 分子名称: 1-THIOETHANESULFONIC ACID, Thioredoxin 著者 Sridhar, V, Chie-Leon, B, Badger, J, Nienaber, V.L, Hausheer, F.H. 登録日 2014-02-25 公開日 2014-10-29 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.52 Å) 主引用文献 BNP7787 Forms Novel Covalent Adducts on Human Thioredoxin and Modulates Thioredoxin Activity J Pharmacol Clin Toxicol, 2, 2014
4POM	Crystal structures of thioredoxin with mesna at 1.85A resolution 分子名称: 1-THIOETHANESULFONIC ACID, Thioredoxin 著者 Sridhar, V, Chie-Leon, B, Badger, J, Nienaber, V.L, Hausheer, F.H. 登録日 2014-02-26 公開日 2014-10-29 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 BNP7787 Forms Novel Covalent Adducts on Human Thioredoxin and Modulates Thioredoxin Activity J Pharmacol Clin Toxicol, 2, 2014
2ERE	Crystal Structure of a Leu3 DNA-binding domain complexed with a 15mer DNA duplex 分子名称: 5'-D(*TP*TP*GP*CP*CP*GP*GP*TP*AP*CP*CP*GP*GP*CP*A)-3', Regulatory protein LEU3, ZINC ION 著者 Fitzgerald, M.X, Marmorstein, R. 登録日 2005-10-24 公開日 2006-04-04 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Structure of a Leu3-DNA complex: recognition of everted CGG half-sites by a Zn2Cys6 binuclear cluster protein. Structure, 14, 2006
2ERG	Crystal Structure of Leu3 DNA-binding domain with a single H50C mutation complexed with a 15mer DNA duplex 分子名称: 5'-D(*TP*TP*GP*CP*CP*GP*GP*TP*AP*CP*CP*GP*GP*CP*A)-3', Regulatory protein LEU3, ZINC ION 著者 Fitzgerald, M.X, Marmorstein, R. 登録日 2005-10-24 公開日 2006-04-04 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (3.15 Å) 主引用文献 Structure of a Leu3-DNA complex: recognition of everted CGG half-sites by a Zn2Cys6 binuclear cluster protein. Structure, 14, 2006
2ER8	Crystal Structure of Leu3 DNA-binding domain complexed with a 12mer DNA duplex 分子名称: 5'-D(*CP*CP*CP*GP*GP*TP*AP*CP*CP*GP*GP*G)-3', Regulatory protein LEU3, ZINC ION 著者 Fitzgerald, M.X, Marmorstein, R. 登録日 2005-10-24 公開日 2006-04-04 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.85 Å) 主引用文献 Structure of a Leu3-DNA complex: recognition of everted CGG half-sites by a Zn2Cys6 binuclear cluster protein. Structure, 14, 2006
3X2W	Michaelis complex of cAMP-dependent Protein Kinase Catalytic Subunit 分子名称: ADENOSINE-5'-TRIPHOSPHATE, CARBONATE ION, MAGNESIUM ION, ... 著者 Das, A, Langan, P, Gerlits, O, Kovalevsky, A.Y, Heller, W.T. 登録日 2015-01-02 公開日 2015-12-16 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Protein Kinase A Catalytic Subunit Primed for Action: Time-Lapse Crystallography of Michaelis Complex Formation. Structure, 23, 2015
3KC0	Crystal structure of human liver FBPase in complex with tricyclic inhibitor 10b 分子名称: Fructose-1,6-bisphosphatase 1, [(8H-indeno[1,2-d][1,3]thiazol-4-yloxy)methyl]phosphonic acid 著者 Takahashi, M, Sone, J, Hanzawa, H. 登録日 2009-10-20 公開日 2010-02-02 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Structure-based drug design of tricyclic 8H-indeno[1,2-d][1,3]thiazoles as potent FBPase inhibitors. Bioorg.Med.Chem.Lett., 20, 2010
3KBZ	Crystal structure of human liver FBPase in complex with tricyclic inhibitor 6 分子名称: Fructose-1,6-bisphosphatase 1, {[(2-amino-8H-indeno[1,2-d][1,3]thiazol-4-yl)oxy]methyl}phosphonic acid 著者 Takahashi, M, Sone, J, Hanzawa, H. 登録日 2009-10-20 公開日 2010-02-02 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.45 Å) 主引用文献 Structure-based drug design of tricyclic 8H-indeno[1,2-d][1,3]thiazoles as potent FBPase inhibitors. Bioorg.Med.Chem.Lett., 20, 2010
3KC1	Crystal structure of human liver FBPase in complex with tricyclic inhibitor 19a 分子名称: Fructose-1,6-bisphosphatase 1, {[(7-carbamoyl-8H-indeno[1,2-d][1,3]thiazol-4-yl)oxy]methyl}phosphonic acid 著者 Takahashi, M, Sone, J, Hanzawa, H. 登録日 2009-10-20 公開日 2010-02-02 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Structure-based drug design of tricyclic 8H-indeno[1,2-d][1,3]thiazoles as potent FBPase inhibitors. Bioorg.Med.Chem.Lett., 20, 2010
6YCS	Human Transcription Cofactor PC4 DNA-binding domain in complex with full phosphorothioate 5-10-5 2'-O-methyl DNA gapmer antisense oligonucleotide. 分子名称: DNA (5'-D(P*(OKQ))-D(P*(OKT))-R(P*(RFJ))-D(*(OKQ)P*(OKT)P*(AS)P*(GS)P*(OKN)P*(OKN)P*(PST)P*(OKN)P*(PST)P*(GS)P*(GS)P*(AS)P*(OKT)P*(OKT))-3'), PC4 protein, SODIUM ION, ... 著者 Hyjek-Skladanowska, M, Vickers, T.A, Napiorkowska, A, Anderson, B, Tanowitz, M, Crooke, S.T, Liang, X, Seth, P.P, Nowotny, M. 登録日 2020-03-19 公開日 2020-04-29 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (3.05 Å) 主引用文献 Origins of the Increased Affinity of Phosphorothioate-Modified Therapeutic Nucleic Acids for Proteins. J.Am.Chem.Soc., 142, 2020
5JR7	Crystal structure of an ACRDYS heterodimer [RIa(92-365):C] of PKA 分子名称: ADENOSINE-5'-DIPHOSPHATE, cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase type I-alpha regulatory subunit 著者 Bruystens, J.G.H, Wu, J, Taylor, S.S. 登録日 2016-05-05 公開日 2017-03-15 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (3.56 Å) 主引用文献 Structure of a PKA RI alpha Recurrent Acrodysostosis Mutant Explains Defective cAMP-Dependent Activation. J. Mol. Biol., 428, 2016
7EZP	Indole-2-carboxylic acid derivatives as allosteric inhibitors of fructose-1,6-bisphosphatase 分子名称: 1,6-di-O-phosphono-beta-D-fructofuranose, 3-(3-hydroxy-3-oxopropyl)-5-(2-methylpropyl)-7-nitro-1H-indole-2-carboxylic acid, Fructose-1,6-bisphosphatase 1 著者 Wang, X.Y, Zhou, J, Xu, B.L. 登録日 2021-06-01 公開日 2022-06-01 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Discovery of Novel Indole Derivatives as Fructose-1,6-bisphosphatase Inhibitors and X-ray Cocrystal Structures Analysis. Acs Med.Chem.Lett., 13, 2022

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