PDB: 37273 件ウェブページステータス検索Chemie searchBIRD

---

4R9Y	Crystal structure of KKOFab in complex with platelet factor 4 分子名称: Platelet factor 4, Platelet factor 4 antibody KKO heavy chain, Platelet factor 4 antibody KKO light chain 著者 Cai, Z, Zhu, Z, Liu, Q, Greene, M.I. 登録日 2014-09-08 公開日 2015-12-16 最終更新日 2017-11-22 実験手法 X-RAY DIFFRACTION (4.11 Å) 主引用文献 Atomic description of the immune complex involved in heparin-induced thrombocytopenia. Nat Commun, 6, 2015
6BMG	Structure of Recombinant Dwarf Sperm Whale Myoglobin (Oxy) 分子名称: ACETATE ION, CADMIUM ION, Myoglobin, ... 著者 Samuel, P.P, Miller, M.D, Xu, W, Alvarado, S, Phillips Jr, G.N, Olson, J.S. 登録日 2017-11-14 公開日 2017-11-29 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.88 Å) 主引用文献 Structure of Recombinant Dwarf Sperm Whale Myoglobin (Oxy) To Be Published
6RVA	STRUCTURE OF [ASP58]-IGF-I ANALOGUE 分子名称: Insulin-like growth factor I 著者 Jiracek, J, Zakova, L, Socha, O. 登録日 2019-05-31 公開日 2019-10-02 最終更新日 2023-06-14 実験手法 SOLUTION NMR 主引用文献 Mutations at hypothetical binding site 2 in insulin and insulin-like growth factors 1 and 2 result in receptor- and hormone-specific responses. J.Biol.Chem., 294, 2019
7THS	Macrocyclic plasmin inhibitor 分子名称: (2S)-butane-1,2-diol, (6S,9R,20R,23S)-N-{[4-(aminomethyl)phenyl]methyl}-20-[(benzenesulfonyl)amino]-3,13,21-trioxo-2,6,9,14,22-pentaazatetracyclo[23.2.2.2~6,9~.2~15,18~]tritriaconta-1(27),15,17,25,28,30-hexaene-23-carboxamide, Plasminogen, ... 著者 Guojie, W. 登録日 2022-01-12 公開日 2023-01-18 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Synthesis and Structural Characterization of Macrocyclic Plasmin Inhibitors. Chemmedchem, 18, 2023
4RCE	Crystal structure of BACE1 in complex with aminooxazoline xanthene inhibitor 2 分子名称: (4S)-2'-(2,2-dimethylpropoxy)-7'-(pyrimidin-5-yl)spiro[1,3-oxazole-4,9'-xanthen]-2-amine, Beta-secretase 1, IODIDE ION 著者 Whittington, D.A, Long, A.M. 登録日 2014-09-15 公開日 2014-12-24 最終更新日 2015-01-14 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Lead Optimization and Modulation of hERG Activity in a Series of Aminooxazoline Xanthene beta-Site Amyloid Precursor Protein Cleaving Enzyme (BACE1) Inhibitors. J.Med.Chem., 57, 2014
4Y8D	Crystal structure of Cyclin-G associated kinase (GAK) complexed with selective 12i inhibitor 分子名称: 1,2-ETHANEDIOL, 2-methoxy-4-[3-(morpholin-4-yl)[1,2]thiazolo[4,3-b]pyridin-6-yl]aniline, Cyclin-G-associated kinase, ... 著者 Chaikuad, A, Heroven, C, Nowak, R, De Jonghe, S, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Knapp, S, Structural Genomics Consortium (SGC) 登録日 2015-02-16 公開日 2015-04-08 最終更新日 2024-10-09 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Selective Inhibitors of Cyclin G Associated Kinase (GAK) as Anti-Hepatitis C Agents. J.Med.Chem., 58, 2015
6RSA	NUCLEAR MAGNETIC RESONANCE AND NEUTRON DIFFRACTION STUDIES OF THE COMPLEX OF RIBONUCLEASE*A WITH URIDINE VANADATE, A TRANSITION-STATE ANALOGUE 分子名称: RIBONUCLEASE A, URIDINE-2',3'-VANADATE 著者 Wlodawer, A. 登録日 1986-02-25 公開日 1986-05-07 最終更新日 2024-06-05 実験手法 NEUTRON DIFFRACTION (2 Å), SOLUTION NMR 主引用文献 Nuclear magnetic resonance and neutron diffraction studies of the complex of ribonuclease A with uridine vanadate, a transition-state analogue. Biochemistry, 24, 1985
6BJ5	Structure of the Clinically used Myxomaviral Serine Protease Inhibitor 1 (SERP-1) 分子名称: 2,5,8,11,14,17-HEXAOXANONADECAN-19-OL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Mahon, B.P, Lomelino, C.L, McKenna, R. 登録日 2017-11-05 公開日 2018-11-07 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structure of the Clinically used Myxomaviral Serine Protease Inhibitor 1 (SERP-1) To Be Published
8FPX	Crystal structure of tumor related RhoA mutant A161P in complex with GDP 分子名称: 1,4-DIETHYLENE DIOXIDE, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... 著者 Lin, Y, Zheng, Y. 登録日 2023-01-05 公開日 2024-06-05 最終更新日 2024-09-04 実験手法 X-RAY DIFFRACTION (1.47 Å) 主引用文献 Tumor-derived RHOA mutants interact with effectors in the GDP-bound state. Nat Commun, 15, 2024
8FPW	Crystal structure of tumor related RhoA mutant A161V in complex with GDP 分子名称: 1,4-DIETHYLENE DIOXIDE, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... 著者 Lin, Y, Zheng, Y. 登録日 2023-01-05 公開日 2024-06-05 最終更新日 2024-09-04 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Tumor-derived RHOA mutants interact with effectors in the GDP-bound state. Nat Commun, 15, 2024
5CNG	ultrafast dynamics in myoglobin: 150 ps time delay 分子名称: CARBON MONOXIDE, Myoglobin, PROTOPORPHYRIN IX CONTAINING FE, ... 著者 Barends, T.R.M, Foucar, L, Ardevol, A, Nass, K, Aquila, A, Botha, S, Doak, R.B, Falahati, K, Hartmann, E, Hilpert, M, Heinz, M, Hoffmann, M, Koefinger, J, Koglin, J, Kovacsova, G, Liang, M, Milathianaki, D, Lemke, H.T, Reinstein, J, Roome, C.M, Shoeman, R.L, Williams, G.J, Burghardt, I, Hummer, G, Boutet, S, Schlichting, I. 登録日 2015-07-17 公開日 2015-09-16 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Direct observation of ultrafast collective motions in CO myoglobin upon ligand dissociation. Science, 350, 2015
8U1Q	A mechanistic understanding of protective influenza B neuraminidase mAbs at the airway interface 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Neuraminidase, mAb-2D10 heavy chain, ... 著者 Ferguson, J.A, Oeverdieck, S, Ward, A.B. 登録日 2023-09-01 公開日 2024-03-27 最終更新日 2024-10-16 実験手法 ELECTRON MICROSCOPY (3.36 Å) 主引用文献 A mechanistic understanding of protective influenza B neuraminidase mAbs at the airway interface To Be Published
4R2D	Egr1/Zif268 zinc fingers in complex with formylated DNA 分子名称: DNA (5'-D(*AP*GP*CP*GP*TP*GP*GP*GP*(5FC)P*GP*T)-3'), DNA (5'-D(*TP*AP*(5FC)P*GP*CP*CP*CP*AP*CP*GP*C)-3'), Early growth response protein 1, ... 著者 Hashimoto, H, Olanrewaju, Y.O, Zheng, Y, Wilson, G.G, Zhang, X, Cheng, X. 登録日 2014-08-11 公開日 2014-10-08 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.088 Å) 主引用文献 Wilms tumor protein recognizes 5-carboxylcytosine within a specific DNA sequence. Genes Dev., 28, 2014
6BKV	Crystal structure of Thioredoxin from Helicobacter pylori (strain G27) 分子名称: Thioredoxin 著者 Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2017-11-09 公開日 2017-12-06 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Crystal structure of Thioredoxin from Helicobacter pylori (strain G27) To be Published
5CEM	Pseudokinase and C-terminal extension of Human Tribbles Homolog 1 分子名称: SULFATE ION, Tribbles homolog 1 著者 Mace, P.D, Nakatani, Y. 登録日 2015-07-07 公開日 2015-11-11 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Molecular Mechanism of CCAAT-Enhancer Binding Protein Recruitment by the TRIB1 Pseudokinase. Structure, 23, 2015
4R2P	Wilms Tumor Protein (WT1) zinc fingers in complex with hydroxymethylated DNA 分子名称: 1,2-ETHANEDIOL, DNA (5'-D(*AP*GP*CP*GP*TP*GP*GP*GP*(5HC)P*GP*T)-3'), DNA (5'-D(*TP*AP*(5HC)P*GP*CP*CP*CP*AP*CP*GP*C)-3'), ... 著者 Hashimoto, H, Olanrewaju, Y.O, Zheng, Y, Wilson, G.G, Zhang, X, Cheng, X. 登録日 2014-08-12 公開日 2014-10-08 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.788 Å) 主引用文献 Wilms tumor protein recognizes 5-carboxylcytosine within a specific DNA sequence. Genes Dev., 28, 2014
6S8Y	Crystal structure of cytochrome c in complex with a sulfonated quinoline-derived foldamer 分子名称: 8-acetamido-2-[[2-[[2-[[2-[[2-[[2-[[2-[(2-carboxy-4-sulfonato-quinolin-8-yl)carbamoyl]-4-sulfonato-quinolin-8-yl]carbamoyl]-4-sulfonato-quinolin-8-yl]carbamoyl]-4-sulfonato-quinolin-8-yl]carbamoyl]-4-sulfonato-quinolin-8-yl]carbamoyl]-4-sulfonato-quinolin-8-yl]carbamoyl]-4-sulfonato-quinolin-8-yl]carbamoyl]quinoline-4-sulfonate, ACETATE ION, Cytochrome c iso-1, ... 著者 Alex, J.M, Corvaglia, V, Hu, X, Engilberge, S, Huc, I, Crowley, P.B. 登録日 2019-07-10 公開日 2019-09-25 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (2.09 Å) 主引用文献 Crystal structure of a protein-aromatic foldamer composite: macromolecular chiral resolution. Chem.Commun.(Camb.), 55, 2019
8DNI	Crystal structure of human KRAS G12C covalently bound with Araxes WO2020/028706A1 compound I-1 分子名称: (4P)-4-(5-methyl-1H-indazol-4-yl)-6-(2-propanoyl-2,6-diazaspiro[3.4]octan-6-yl)-2-(pyrrolidin-1-yl)pyrimidine-5-carbonitrile, GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, ... 著者 Mohr, C. 登録日 2022-07-11 公開日 2022-08-17 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Modeling receptor flexibility in the structure-based design of KRAS G12C inhibitors. J.Comput.Aided Mol.Des., 36, 2022
4YU2	Crystal structure of DYRK1A with harmine-derivatized AnnH-75 inhibitor 分子名称: (1-chloro-7-methoxy-9H-beta-carbolin-9-yl)acetonitrile, Dual specificity tyrosine-phosphorylation-regulated kinase 1A, SULFATE ION, ... 著者 Chaikuad, A, Wurzlbauer, A, Nowak, R, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Bracher, F, Knapp, S, Structural Genomics Consortium (SGC) 登録日 2015-03-18 公開日 2015-03-25 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 How to Separate Kinase Inhibition from Undesired Monoamine Oxidase A Inhibition-The Development of the DYRK1A Inhibitor AnnH75 from the Alkaloid Harmine. Molecules, 25, 2020
4R3C	Crystal structure of p38 alpha MAP kinase in complex with a novel isoform selective drug candidate 分子名称: 4-[3-(4-FLUOROPHENYL)-1H-PYRAZOL-4-YL]PYRIDINE, 6-(4-methylpiperazin-1-yl)-3-(naphthalen-2-yl)-4-(pyridin-4-yl)pyridazine, CHLORIDE ION, ... 著者 Grum-Tokars, V.L, Minasov, G, Roy, S.M, Anderson, W.F, Watterson, D.M. 登録日 2014-08-14 公開日 2015-02-25 最終更新日 2017-11-22 実験手法 X-RAY DIFFRACTION (2.06 Å) 主引用文献 Targeting human central nervous system protein kinases: An isoform selective p38 alpha MAPK inhibitor that attenuates disease progression in Alzheimer's disease mouse models. ACS Chem Neurosci, 6, 2015
8DNJ	Crystal structure of human KRAS G12C covalently bound with AstraZeneca WO2020/178282A1 compound 76 分子名称: 1-[(5S,9P,12aR)-9-(2-chloro-6-hydroxyphenyl)-8-ethynyl-10-fluoro-3,4,12,12a-tetrahydro-6H-pyrazino[2,1-c][1,4]benzoxazepin-2(1H)-yl]propan-1-one, GUANOSINE-5'-DIPHOSPHATE, Isoform 2B of GTPase KRas, ... 著者 Mohr, C. 登録日 2022-07-11 公開日 2022-08-17 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (1.81 Å) 主引用文献 Modeling receptor flexibility in the structure-based design of KRAS G12C inhibitors. J.Comput.Aided Mol.Des., 36, 2022
5WB1	Ligand-free US28 with stabilizing intracellular nanobody 分子名称: Envelope protein US28, nanobody 7 fusion protein 著者 Jude, K.M, Burg, J.S, Garcia, K.C. 登録日 2017-06-27 公開日 2018-06-13 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (3.508 Å) 主引用文献 Viral GPCR US28 can signal in response to chemokine agonists of nearly unlimited structural degeneracy. Elife, 7, 2018
8DZT	Crystal structure of human Sar1aH79G mutant 分子名称: CALCIUM ION, GTP-binding protein SAR1a, GUANOSINE-5',3'-TETRAPHOSPHATE, ... 著者 Huang, Q. 登録日 2022-08-08 公開日 2022-11-30 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 The alarmone ppGpp selectively inhibits the isoform A of the human small GTPase Sar1. Proteins, 91, 2023
7U08	Structure of CD148 fibronectin type III domain 1 and 2 分子名称: PLATINUM (II) ION, Receptor-type tyrosine-protein phosphatase eta 著者 Zhou, D, Zhu, J. 登録日 2022-02-17 公開日 2023-02-22 実験手法 X-RAY DIFFRACTION (3.30691743 Å) 主引用文献 Structure of CD148 fibronectin type III domain 1 and 2 To Be Published
5WK3	CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN CCL17 AND M116 FAB 分子名称: C-C motif chemokine 17, GLYCEROL, M116 HEAVY CHAIN, ... 著者 Teplyakov, A, Obmolova, G, Gilliland, G.L. 登録日 2017-07-24 公開日 2017-12-20 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structural insights into chemokine CCL17 recognition by antibody M116. Biochem Biophys Rep, 13, 2018

<231232233234235236237238239240241242243244245246>