6S8Y

Crystal structure of cytochrome c in complex with a sulfonated quinoline-derived foldamer

Summary for 6S8Y

Entry DOI	10.2210/pdb6s8y/pdb
Descriptor	Cytochrome c iso-1, HEME C, ZINC ION, ... (6 entities in total)
Functional Keywords	charge interactions, cytochrome c, protein assembly, protein recognition, quinoline foldamer, oxidoreductase
Biological source	Saccharomyces cerevisiae (Baker's yeast)
Total number of polymer chains	1
Total formula weight	17011.18
Authors	Alex, J.M.,Corvaglia, V.,Hu, X.,Engilberge, S.,Huc, I.,Crowley, P.B. (deposition date: 2019-07-10, release date: 2019-09-25, Last modification date: 2024-10-16)
Primary citation	Alex, J.M.,Corvaglia, V.,Hu, X.,Engilberge, S.,Huc, I.,Crowley, P.B. Crystal structure of a protein-aromatic foldamer composite: macromolecular chiral resolution. Chem.Commun.(Camb.), 55:11087-11090, 2019 Cited by PubMed Abstract: Co-crystallization of a 2 kDa tether-free sulfonated foldamer and the 13 kDa lysine-rich cytochrome c yielded a remarkable biohybrid assembly with chiral resolution of the foldamer helix handedness. In the crystal a ∼5 nm foldamer stack was surrounded by eight molecules of protein. NMR and CD experiments suggest interesting differences in the solution state recognition processes. PubMed: 31460523 DOI: 10.1039/c9cc05330a PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.09 Å)

Structure validation