4Y8D

Crystal structure of Cyclin-G associated kinase (GAK) complexed with selective 12i inhibitor

Summary for 4Y8D

Entry DOI	10.2210/pdb4y8d/pdb
Descriptor	Cyclin-G-associated kinase, nanobody, 2-methoxy-4-[3-(morpholin-4-yl)[1,2]thiazolo[4,3-b]pyridin-6-yl]aniline, ... (5 entities in total)
Functional Keywords	transferase, kinase, nanobody, inhibitor, structural genomics, structural genomics consortium, sgc
Biological source	Homo sapiens (Human) More
Cellular location	Cytoplasm, perinuclear region : O14976
Total number of polymer chains	4
Total formula weight	107533.29
Authors	Chaikuad, A.,Heroven, C.,Nowak, R.,De Jonghe, S.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2015-02-16, release date: 2015-04-08, Last modification date: 2024-01-10)
Primary citation	Kovackova, S.,Chang, L.,Bekerman, E.,Neveu, G.,Barouch-Bentov, R.,Chaikuad, A.,Heroven, C.,Sala, M.,De Jonghe, S.,Knapp, S.,Einav, S.,Herdewijn, P. Selective Inhibitors of Cyclin G Associated Kinase (GAK) as Anti-Hepatitis C Agents. J.Med.Chem., 58:3393-3410, 2015 Cited by PubMed: 25822739 DOI: 10.1021/jm501759m PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation