4Y8D
Crystal structure of Cyclin-G associated kinase (GAK) complexed with selective 12i inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, B) | Cyclin-G-associated kinase | polymer | 340 | 38183.6 | 2 | UniProt (O14976) Pfam (PF00069) | Homo sapiens (Human) | |
| 2 | B, D (C, D) | nanobody | polymer | 140 | 15085.5 | 2 | Lama glama | ||
| 3 | E, H (A, B) | 2-methoxy-4-[3-(morpholin-4-yl)[1,2]thiazolo[4,3-b]pyridin-6-yl]aniline | non-polymer | 342.4 | 2 | Chemie (49J) | |||
| 4 | F, G, I, J, K (C, B, D) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 5 | Chemie (EDO) | |||
| 5 | L, M, N, O (A, C, B, D) | water | water | 18.0 | 394 | Chemie (HOH) |
Sequence modifications
A, B: 14 - 351 (UniProt: O14976)
| PDB | External Database | Details |
|---|---|---|
| Ser 12 | - | expression tag |
| Met 13 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 106538.1 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 995.2 | |
| All* | Total formula weight | 107533.3 |
