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4HPN
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BU of 4hpn by Molmil
Crystal structure of a proposed galactarolactone cycloisomerase from Agrobacterium Tumefaciens, target EFI-500704, with bound Ca, ordered loops
分子名称: CALCIUM ION, IMIDAZOLE, NICKEL (II) ION, ...
著者Vetting, M.W, Bouvier, J.T, Morisco, L.L, Wasserman, S.R, Sojitra, S, Imker, H.J, Gerlt, J.A, Almo, S.C, Enzyme Function Initiative (EFI)
登録日2012-10-24
公開日2012-11-07
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Purification, crystallization and structural elucidation of D-galactaro-1,4-lactone cycloisomerase from Agrobacterium tumefaciens involved in pectin degradation.
Acta Crystallogr F Struct Biol Commun, 72, 2016
4I09
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BU of 4i09 by Molmil
structure of the mutant Catabolite gene activator protein V132L
分子名称: ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Catabolite gene activator
著者Pohl, E, Townsend, P.D, Rodgers, T, Burnell, D, McLeish, T.C.B, Wilson, M.R, Cann, M.J.
登録日2012-11-16
公開日2013-10-30
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Modulation of global low-frequency motions underlies allosteric regulation: demonstration in CRP/FNR family transcription factors.
Plos Biol., 11, 2013
7DL7
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BU of 7dl7 by Molmil
The wild-type structure of 3,5-DAHDHcca
分子名称: 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 3,5-diaminohexanoate dehydrogenase, ...
著者Liu, N, Wu, L, Zhu, D.M, Zhou, J.H.
登録日2020-11-26
公開日2021-09-29
最終更新日2024-05-29
実験手法X-RAY DIFFRACTION (2.30065823 Å)
主引用文献Crystal Structures and Catalytic Mechanism of l-erythro-3,5-Diaminohexanoate Dehydrogenase and Rational Engineering for Asymmetric Synthesis of beta-Amino Acids.
Angew.Chem.Int.Ed.Engl., 60, 2021
4KYZ
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BU of 4kyz by Molmil
Three-dimensional structure of triclinic form of de novo design insertion domain, Northeast Structural Genomics Consortium (NESG) Target OR327
分子名称: Designed protein OR327
著者Kuzin, A, Su, M, Seetharaman, J, Maglaqui, M, Xiao, R, Lee, D, Gleixner, J, Baker, D, Everett, J.K, Acton, T.B, Kornhaber, G, Montelione, G.T, Hunt, J.F, Tong, L, Northeast Structural Genomics Consortium (NESG)
登録日2013-05-29
公開日2013-07-24
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (2.492 Å)
主引用文献Precise assembly of complex beta sheet topologies from de novo designed building blocks.
Elife, 4, 2015
1YRS
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BU of 1yrs by Molmil
Crystal structure of KSP in complex with inhibitor 1
分子名称: 3-[(5S)-1-ACETYL-3-(2-CHLOROPHENYL)-4,5-DIHYDRO-1H-PYRAZOL-5-YL]PHENOL, ADENOSINE-5'-DIPHOSPHATE, Kinesin-like protein KIF11, ...
著者Cox, C.D, Breslin, M.J, Mariano, B.J, Coleman, P.J, Buser, C.A, Walsh, E.S, Hamilton, K, Kohl, N.E, Torrent, M, Yan, Y, Kuo, L.C, Hartman, G.D.
登録日2005-02-04
公開日2005-04-12
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Kinesin spindle protein (KSP) inhibitors. Part 1: The discovery of 3,5-diaryl-4,5-dihydropyrazoles as potent and selective inhibitors of the mitotic kinesin KSP
BIOORG.MED.CHEM.LETT., 15, 2005
5BRL
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BU of 5brl by Molmil
Crystal Structure of L124D STARD4
分子名称: StAR-related lipid transfer protein 4
著者Iaea, D.B, Dikiy, I, Kiburu, I, Eliezer, D.E, Maxfield, F.R.
登録日2015-05-31
公開日2015-07-22
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.003 Å)
主引用文献STARD4 Membrane Interactions and Sterol Binding.
Biochemistry, 54, 2015
6IAR
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BU of 6iar by Molmil
Tricyclic indazoles a novel class of selective estrogen receptor degrader antagonists
分子名称: 3-[4-[(6~{R})-7-(2-methylpropyl)-3,6,8,9-tetrahydropyrazolo[4,3-f]isoquinolin-6-yl]phenyl]propanoic acid, Estrogen receptor
著者Scott, J.S, Bailey, A, Buttar, D, Carbajo, R.J, Curwen, J, Davies, R.D.M, Degorce, S.L, Donald, C, Gangl, E, Greenwood, R, Groombridge, S.D, Johnson, T, Lamont, S, Lawson, M, Lister, A, Morrow, C, Moss, T, Pink, J.H, Polanski, R.
登録日2018-11-27
公開日2019-01-23
最終更新日2024-05-15
実験手法X-RAY DIFFRACTION (1.84 Å)
主引用文献Tricyclic Indazoles-A Novel Class of Selective Estrogen Receptor Degrader Antagonists.
J.Med.Chem., 62, 2019
2OPE
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BU of 2ope by Molmil
Crystal structure of the Neisseria meningitidis minor Type IV pilin, PilX, in space group P43
分子名称: PilX
著者Dyer, D.H, Helaine, S, Pelicic, V, Forest, K.T.
登録日2007-01-29
公開日2007-10-23
最終更新日2024-10-09
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献3D structure/function analysis of PilX reveals how minor pilins can modulate the virulence properties of type IV pili.
Proc.Natl.Acad.Sci.Usa, 104, 2007
7LOM
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BU of 7lom by Molmil
Ornithine Aminotransferase (OAT) soaked with its inactivator - (1S,3S)-3-amino-4-(difluoromethylene)cyclohexene-1-carboxylic acid
分子名称: (3~{S},4~{S})-4-methyl-3-[[2-methyl-3-oxidanyl-5-(phosphonooxymethyl)pyridin-4-yl]methylamino]cyclohexene-1-carboxylic acid, (4~{R})-4-(fluoranylmethyl)-3-[[2-methyl-3-oxidanyl-5-(phosphonooxymethyl)pyridin-4-yl]methylamino]cyclohexene-1-carboxylic acid, Ornithine aminotransferase, ...
著者Butrin, A, Zhu, W, Liu, D, Silverman, R.
登録日2021-02-10
公開日2021-08-25
最終更新日2024-12-25
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Remarkable and Unexpected Mechanism for ( S )-3-Amino-4-(difluoromethylenyl)cyclohex-1-ene-1-carboxylic Acid as a Selective Inactivator of Human Ornithine Aminotransferase.
J.Am.Chem.Soc., 143, 2021
1GN4
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BU of 1gn4 by Molmil
H145E mutant of Mycobacterium tuberculosis iron-superoxide dismutase.
分子名称: MANGANESE (II) ION, SUPEROXIDE DISMUTASE
著者Bunting, K.A, Cooper, J.B, Badasso, M.O, Tickle, I.J, Newton, M, Wood, S.P, Zhang, Y, Young, D.B.
登録日2001-10-02
公開日2001-10-05
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Engineering a Change in the Metal-Ion Specificity of the Iron-Depedent Superoxide Dismutase from Mycobacterium Tuberculosis. X-Ray Structure Analysis of Site-Directed Mutants
Eur.J.Biochem., 251, 1998
2IDV
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BU of 2idv by Molmil
Crystal structure of wheat C113S mutant EIF4E bound TO 7-methyl-GDP
分子名称: 7N-METHYL-8-HYDROGUANOSINE-5'-DIPHOSPHATE, Eukaryotic translation initiation factor 4E-1
著者Monzingo, A.F, Dutt-Chaudhuri, A, Sadow, J, Dhaliwal, S, Hoffman, D.W, Robertus, J.D, Browning, K.S.
登録日2006-09-15
公開日2007-06-12
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献The structure of eukaryotic translation initiation factor-4E from wheat reveals a novel disulfide bond.
Plant Physiol., 143, 2007
2OQF
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BU of 2oqf by Molmil
Structure of a synthetic, non-natural analogue of RNase A: [N71K(Ade), D83A]RNase A
分子名称: Ribonuclease pancreatic
著者Boerema, D.J, Tereshko, V.A, Zhang, J.L, He, C, Kent, S.B.H.
登録日2007-01-31
公開日2008-02-12
最終更新日2024-11-06
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Design, Synthesis, and Characterization of Non-natural RNase A Analogues with Enhanced Second-step Catalytic Activity
To be Published
3CY1
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BU of 3cy1 by Molmil
Crystal structure of the cytochrome P450 CYP121 S279A mutant from M. tuberculosis
分子名称: Cytochrome P450 121, PROTOPORPHYRIN IX CONTAINING FE, SULFATE ION
著者Leys, D.
登録日2008-04-25
公開日2008-09-23
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Characterisation of active site of cytochrome P450 CYP121
TO BE PUBLISHED
4CM4
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BU of 4cm4 by Molmil
Crystal structure of pteridine reductase 1 (PTR1) from Trypanosoma brucei in ternary complex with cofactor and inhibitor
分子名称: 5-(4-fluorophenyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine, ACETATE ION, GLYCEROL, ...
著者Barrack, K.L, Hunter, W.N.
登録日2014-01-15
公開日2015-01-21
最終更新日2025-04-09
実験手法X-RAY DIFFRACTION (1.81 Å)
主引用文献Structure-Based Design and Synthesis of Antiparasitic Pyrrolopyrimidines Targeting Pteridine Reductase 1.
J.Med.Chem., 57, 2014
7LNM
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BU of 7lnm by Molmil
Ornithine Aminotransferase (OAT) cocrystallized with its inactivator - (1S,3S)-3-amino-4-(difluoromethylene)cyclopentene-1-carboxylic acid
分子名称: (1~{R},3~{S},4~{R})-3-methyl-4-[[2-methyl-3-oxidanyl-5-(phosphonooxymethyl)pyridin-4-yl]methylamino]cyclopentane-1-carboxylic acid, Ornithine aminotransferase, mitochondrial
著者Butrin, A, Catlin, D, Zhu, W, Liu, D, Silverman, R.
登録日2021-02-07
公開日2021-08-25
最終更新日2024-12-25
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Remarkable and Unexpected Mechanism for ( S )-3-Amino-4-(difluoromethylenyl)cyclohex-1-ene-1-carboxylic Acid as a Selective Inactivator of Human Ornithine Aminotransferase.
J.Am.Chem.Soc., 143, 2021
2ILU
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BU of 2ilu by Molmil
Crystal structure of lactaldehyde dehydrogenase from E. coli: the binary complex with NADPH
分子名称: Aldehyde dehydrogenase A, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, SULFATE ION
著者Di Costanzo, L, Gomez, G, Christianson, D.W.
登録日2006-10-03
公開日2007-05-08
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Crystal structure of lactaldehyde dehydrogenase from Escherichia coli and inferences regarding substrate and cofactor specificity.
J.Mol.Biol., 366, 2007
4DDF
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BU of 4ddf by Molmil
Computationally Designed Self-assembling Octahedral Cage protein, O333, Crystallized in space group P4
分子名称: CHLORIDE ION, Propanediol utilization polyhedral body protein PduT, SULFATE ION
著者Sawaya, M.R, King, N.P, Sheffler, W, Baker, D, Yeates, T.O.
登録日2012-01-18
公開日2012-06-06
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (3.15 Å)
主引用文献Computational design of self-assembling protein nanomaterials with atomic level accuracy.
Science, 336, 2012
7LON
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BU of 7lon by Molmil
Ornithine Aminotransferase (OAT) cocrystallized with its inactivator - (1S,3S)-3-amino-4-(difluoromethylene)cyclohexene-1-carboxylic acid
分子名称: (1R,3S,4R)-3-[({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)amino]-4-methylcyclohexane-1-carboxylic acid, Ornithine aminotransferase, mitochondrial, ...
著者Butrin, A, Zhu, W, Liu, D, Silverman, R.
登録日2021-02-10
公開日2021-08-25
最終更新日2024-11-06
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Remarkable and Unexpected Mechanism for ( S )-3-Amino-4-(difluoromethylenyl)cyclohex-1-ene-1-carboxylic Acid as a Selective Inactivator of Human Ornithine Aminotransferase.
J.Am.Chem.Soc., 143, 2021
5TVV
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BU of 5tvv by Molmil
Computationally Designed Fentanyl Binder - Fen49* Apo
分子名称: Endo-1,4-beta-xylanase A, POTASSIUM ION
著者Bick, M.J, Greisen, P.J, Morey, K.J, Antunes, A.S, La, D, Sankaran, B, Reymond, L, Johnsson, K, Medford, J.I, Baker, D.
登録日2016-11-10
公開日2017-10-04
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.79 Å)
主引用文献Computational design of environmental sensors for the potent opioid fentanyl.
Elife, 6, 2017
4HDV
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BU of 4hdv by Molmil
Crystal structure of S. pombe ATL1 in complex with damaged DNA containing 2,6-diaminopurine
分子名称: 5'-D(*CP*TP*AP*CP*TP*AP*GP*CP*CP*AP*TP*GP*G)-3', 5'-D(*GP*CP*CP*AP*TP*GP*(1AP)P*CP*TP*AP*GP*TP*A)-3', Alkyltransferase-like protein 1
著者Tubbs, J.L, Tainer, J.A.
登録日2012-10-02
公開日2012-12-26
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.702 Å)
主引用文献Alkyltransferase-like protein (Atl1) distinguishes alkylated guanines for DNA repair using cation-{pi} interactions.
Proc.Natl.Acad.Sci.USA, 109, 2012
4OYL
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BU of 4oyl by Molmil
Humicola insolens cutinase in complex with mono-ethylphosphate
分子名称: Cutinase
著者Dauter, Z.D, Brzozowski, A.M, Turkenburg, J.P, Wilson, K.S.
登録日2014-02-12
公開日2014-06-25
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Thermodynamic and structural investigation of the specific SDS binding of Humicola insolens cutinase.
Protein Sci., 23, 2014
1CFR
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BU of 1cfr by Molmil
CRYSTAL STRUCTURE OF CITROBACTER FREUNDII RESTRICTION ENDONUCLEASE CFR10I AT 2.15 ANGSTROMS RESOLUTION.
分子名称: RESTRICTION ENDONUCLEASE
著者Bozic, D, Grazulis, S, Siksnys, V, Huber, R.
登録日1996-02-02
公開日1997-01-27
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Crystal structure of Citrobacter freundii restriction endonuclease Cfr10I at 2.15 A resolution.
J.Mol.Biol., 255, 1996
4DOY
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BU of 4doy by Molmil
Crystal structure of Dibenzothiophene desulfurization enzyme C
分子名称: Dibenzothiophene desulfurization enzyme C, GLYCEROL
著者Liu, S, Zhang, C, Zhu, D, Gu, L.
登録日2012-02-12
公開日2013-02-13
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (1.789 Å)
主引用文献Crystal structure of DszC from Rhodococcus sp. XP at 1.79 angstrom
Proteins, 82, 2014
6F0I
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BU of 6f0i by Molmil
GLIC mutant E26A
分子名称: ACETATE ION, CHLORIDE ION, DIUNDECYL PHOSPHATIDYL CHOLINE, ...
著者Hu, H.D, Delarue, M.
登録日2017-11-20
公開日2018-01-10
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Full mutational mapping of titratable residues helps to identify proton-sensors involved in the control of channel gating in the Gloeobacter violaceus pentameric ligand-gated ion channel.
PLoS Biol., 15, 2017
3CL9
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BU of 3cl9 by Molmil
Structure of bifunctional TcDHFR-TS in complex with MTX
分子名称: 1,2-ETHANEDIOL, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, Bifunctional dihydrofolate reductase-thymidylate synthase (DHFR-TS), ...
著者Schormann, N, Senkovich, O, Chattopadhyay, D.
登録日2008-03-18
公開日2009-01-06
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献Structure-based approach to pharmacophore identification, in silico screening, and three-dimensional quantitative structure-activity relationship studies for inhibitors of Trypanosoma cruzi dihydrofolate reductase function.
Proteins, 73, 2008

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