3IPH

Crystal structure of p38 in complex with a biphenylamide inhibitor

Summary for 3IPH

Entry DOI	10.2210/pdb3iph/pdb
Related	2ZAZ 2ZB0 2ZB1 3D7Z 3D83
Descriptor	Mitogen-activated protein kinase 14, 6-[5-(cyclopropylcarbamoyl)-2-methylphenyl]-N-(cyclopropylmethyl)pyridine-3-carboxamide, SULFATE ION, ... (5 entities in total)
Functional Keywords	p38, serine/threonine protein kinase, map kinase, atp-binding, kinase, nucleotide-binding, nucleus, phosphoprotein, serine/threonine-protein kinase, transferase
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm : Q16539
Total number of polymer chains	1
Total formula weight	42373.25
Authors	Somers, D.O. (deposition date: 2009-08-17, release date: 2009-11-24, Last modification date: 2023-11-22)
Primary citation	Aston, N.M.,Bamborough, P.,Buckton, J.B.,Edwards, C.D.,Holmes, D.S.,Jones, K.L.,Patel, V.K.,Smee, P.A.,Somers, D.O.,Vitulli, G.,Walker, A.L. p38alpha mitogen-activated protein kinase inhibitors: optimization of a series of biphenylamides to give a molecule suitable for clinical progression. J.Med.Chem., 52:6257-6269, 2009 Cited by PubMed: 19772287 DOI: 10.1021/jm9004779 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation