3D7Z
Crystal Structure of P38 Kinase in Complex with a biphenyl amide inhibitor
Summary for 3D7Z
Entry DOI | 10.2210/pdb3d7z/pdb |
Related | 2ZB0 2ZB1 3D83 |
Descriptor | Mitogen-activated protein kinase 14, SULFATE ION, N~3~-cyclopropyl-N~4~'-(cyclopropylmethyl)-6-methylbiphenyl-3,4'-dicarboxamide, ... (5 entities in total) |
Functional Keywords | p38, serine/threonine protein kinase, map kinase, atp-binding, nucleotide-binding, nucleus, phosphoprotein, serine/threonine-protein kinase, transferase |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm : Q16539 |
Total number of polymer chains | 1 |
Total formula weight | 41895.79 |
Authors | Somers, D.O.,Patel, S. (deposition date: 2008-05-22, release date: 2008-07-22, Last modification date: 2023-11-15) |
Primary citation | Angell, R.,Aston, N.M.,Bamborough, P.,Buckton, J.B.,Cockerill, S.,deBoeck, S.J.,Edwards, C.D.,Holmes, D.S.,Jones, K.L.,Laine, D.I.,Patel, S.,Smee, P.A.,Smith, K.J.,Somers, D.O.,Walker, A.L. Biphenyl amide p38 kinase inhibitors 3: Improvement of cellular and in vivo activity. Bioorg.Med.Chem.Lett., 18:4428-4432, 2008 Cited by PubMed: 18614366DOI: 10.1016/j.bmcl.2008.06.048 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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