3D7Z

Crystal Structure of P38 Kinase in Complex with a biphenyl amide inhibitor

Summary for 3D7Z

Entry DOI	10.2210/pdb3d7z/pdb
Related	2ZB0 2ZB1 3D83
Descriptor	Mitogen-activated protein kinase 14, SULFATE ION, N~3~-cyclopropyl-N~4~'-(cyclopropylmethyl)-6-methylbiphenyl-3,4'-dicarboxamide, ... (5 entities in total)
Functional Keywords	p38, serine/threonine protein kinase, map kinase, atp-binding, nucleotide-binding, nucleus, phosphoprotein, serine/threonine-protein kinase, transferase
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm : Q16539
Total number of polymer chains	1
Total formula weight	41895.79
Authors	Somers, D.O.,Patel, S. (deposition date: 2008-05-22, release date: 2008-07-22, Last modification date: 2024-11-13)
Primary citation	Angell, R.,Aston, N.M.,Bamborough, P.,Buckton, J.B.,Cockerill, S.,deBoeck, S.J.,Edwards, C.D.,Holmes, D.S.,Jones, K.L.,Laine, D.I.,Patel, S.,Smee, P.A.,Smith, K.J.,Somers, D.O.,Walker, A.L. Biphenyl amide p38 kinase inhibitors 3: Improvement of cellular and in vivo activity. Bioorg.Med.Chem.Lett., 18:4428-4432, 2008 Cited by PubMed Abstract: The biphenyl amides (BPAs) are a novel series of p38alpha MAP kinase inhibitor. The optimisation of the series to give compounds that are potent in an in vivo disease model is discussed. SAR is presented and rationalised with reference to the crystallographic binding mode. PubMed: 18614366 DOI: 10.1016/j.bmcl.2008.06.048 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation