3D83

Crystal structure of P38 kinase in complex with a biphenyl amide inhibitor

Summary for 3D83

Entry DOI	10.2210/pdb3d83/pdb
Related	2ZB0 2ZB1 3D7Z
Descriptor	Mitogen-activated protein kinase 14, N-{4'-[(cyclopropylmethyl)carbamoyl]-6-methylbiphenyl-3-yl}-2-morpholin-4-ylpyridine-4-carboxamide, GLYCEROL, ... (4 entities in total)
Functional Keywords	p38, serine/threonine protein kinase, map kinase, atp-binding, nucleotide-binding, nucleus, phosphoprotein, serine/threonine-protein kinase, transferase
Biological source	Homo sapiens
Cellular location	Cytoplasm : Q16539
Total number of polymer chains	1
Total formula weight	41937.85
Authors	Somers, D.O. (deposition date: 2008-05-22, release date: 2008-07-22, Last modification date: 2023-11-15)
Primary citation	Angell, R.M.,Angell, T.D.,Bamborough, P.,Bamford, M.J.,Chung, C.W.,Cockerill, S.G.,Flack, S.S.,Jones, K.L.,Laine, D.I.,Longstaff, T.,Ludbrook, S.,Pearson, R.,Smith, K.J.,Smee, P.A.,Somers, D.O.,Walker, A.L. Biphenyl amide p38 kinase inhibitors 4: DFG-in and DFG-out binding modes. Bioorg.Med.Chem.Lett., 18:4433-4437, 2008 Cited by PubMed: 18602262 DOI: 10.1016/j.bmcl.2008.06.028 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation