2ZB1

Crystal structure of P38 in complex with biphenyl amide inhibitor

Summary for 2ZB1

Entry DOI	10.2210/pdb2zb1/pdb
Related	2ZAZ 2ZB0
Descriptor	Mitogen-activated protein kinase 14, N-(cyclopropylmethyl)-2'-methyl-5'-(5-methyl-1,3,4-oxadiazol-2-yl)biphenyl-4-carboxamide, GLYCEROL, ... (4 entities in total)
Functional Keywords	serine/threonine protein kinase, map kinase, p38, atp-binding, nucleotide-binding, nucleus, phosphorylation, transferase
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm : Q16539
Total number of polymer chains	1
Total formula weight	41874.79
Authors	Somers, D.O. (deposition date: 2007-10-13, release date: 2008-01-15, Last modification date: 2024-03-13)
Primary citation	Angell, R.M.,Bamborough, P.,Cleasby, A.,Cockerill, S.G.,Jones, K.L.,Mooney, C.J.,Somers, D.O.,Walker, A.L. Biphenyl amide p38 kinase inhibitors 1: Discovery and binding mode Bioorg.Med.Chem.Lett., 18:318-323, 2008 Cited by PubMed Abstract: The biphenyl amides (BPAs) are a novel series of p38 MAP kinase inhibitors. The discovery of the series through structure-based focused screening is described, and the binding mode of the compounds is explained with reference to X-ray crystal structures. PubMed: 18006306 DOI: 10.1016/j.bmcl.2007.10.076 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation