3D83
Crystal structure of P38 kinase in complex with a biphenyl amide inhibitor
Summary for 3D83
Entry DOI | 10.2210/pdb3d83/pdb |
Related | 2ZB0 2ZB1 3D7Z |
Descriptor | Mitogen-activated protein kinase 14, N-{4'-[(cyclopropylmethyl)carbamoyl]-6-methylbiphenyl-3-yl}-2-morpholin-4-ylpyridine-4-carboxamide, GLYCEROL, ... (4 entities in total) |
Functional Keywords | p38, serine/threonine protein kinase, map kinase, atp-binding, nucleotide-binding, nucleus, phosphoprotein, serine/threonine-protein kinase, transferase |
Biological source | Homo sapiens |
Cellular location | Cytoplasm : Q16539 |
Total number of polymer chains | 1 |
Total formula weight | 41937.85 |
Authors | Somers, D.O. (deposition date: 2008-05-22, release date: 2008-07-22, Last modification date: 2023-11-15) |
Primary citation | Angell, R.M.,Angell, T.D.,Bamborough, P.,Bamford, M.J.,Chung, C.W.,Cockerill, S.G.,Flack, S.S.,Jones, K.L.,Laine, D.I.,Longstaff, T.,Ludbrook, S.,Pearson, R.,Smith, K.J.,Smee, P.A.,Somers, D.O.,Walker, A.L. Biphenyl amide p38 kinase inhibitors 4: DFG-in and DFG-out binding modes. Bioorg.Med.Chem.Lett., 18:4433-4437, 2008 Cited by PubMed: 18602262DOI: 10.1016/j.bmcl.2008.06.028 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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