PDB: 13252 件ウェブページステータス検索Chemie searchBIRD

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5YV0	DNA polymerase IV - DNA ternary complex 12 分子名称: DIPHOSPHATE, DNA polymerase IV, DTN1, ... 著者 Kottur, J, Nair, D.T. 登録日 2017-11-23 公開日 2018-11-14 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.09 Å) 主引用文献 Pyrophosphate hydrolysis is an intrinsic and critical step of the DNA synthesis reaction. Nucleic Acids Res., 46, 2018
3HMH	Crystal structure of the second bromodomain of human TBP-associated factor RNA polymerase 1-like (TAF1L) 分子名称: Transcription initiation factor TFIID 210 kDa subunit 著者 Filippakopoulos, P, Picaud, S, Keates, T, Zhang, Y, Pike, A.C.W, von Delft, F, Arrowsmith, C.H, Edwards, A, Weigelt, J, Bountra, C, Knapp, S, Structural Genomics Consortium (SGC) 登録日 2009-05-29 公開日 2009-06-23 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Histone recognition and large-scale structural analysis of the human bromodomain family. Cell(Cambridge,Mass.), 149, 2012
5ZLV	DNA polymerase IV - DNA ternary complex with 50mM MgCl2 分子名称: DIPHOSPHATE, DNA polymerase IV, DTN1, ... 著者 Kottur, J, Nair, D.T. 登録日 2018-03-29 公開日 2018-11-07 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Pyrophosphate hydrolysis is an intrinsic and critical step of the DNA synthesis reaction Nucleic Acids Res., 46, 2018
3NKB	A 1.9A crystal structure of the HDV ribozyme precleavage suggests both Lewis acid and general acid mechanisms contribute to phosphodiester cleavage 分子名称: DNA/RNA (5'-D(*(DUR))-D(*GP*G)-R(P*CP*UP*UP*GP*CP*A)-3'), MAGNESIUM ION, The hepatitis delta virus ribozyme 著者 Chen, J.-H, Yajima, R, Chadalavada, D.M, Chase, E, Bevilacqua, P.C, Golden, B.L. 登録日 2010-06-18 公開日 2010-09-01 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.916 Å) 主引用文献 A 1.9 A crystal structure of the HDV ribozyme precleavage suggests both Lewis acid and general acid mechanisms contribute to phosphodiester cleavage. Biochemistry, 49, 2010
3NHG	RB69 DNA Polymerase (S565G/Y567A) Ternary Complex with dTTP Opposite dG 分子名称: CALCIUM ION, DNA (5'-D(*GP*CP*GP*GP*AP*CP*TP*GP*CP*TP*TP*AP*(DOC))-3'), DNA (5'-D(*TP*CP*AP*GP*GP*TP*AP*AP*GP*CP*AP*GP*TP*CP*CP*GP*CP*G)-3'), ... 著者 Wang, M, Wang, J, Konigsberg, W.H. 登録日 2010-06-14 公開日 2011-01-26 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Variation in Mutation Rates Caused by RB69pol Fidelity Mutants Can Be Rationalized on the Basis of Their Kinetic Behavior and Crystal Structures. J.Mol.Biol., 406, 2011
4QJD	Crystal Structure of Twister with the Nucleotide 5'- to the Cleavage Site Disordered at 3.1 A Resolution 分子名称: MAGNESIUM ION, Twister RNA sequence 著者 Eiler, D.R, Wang, J, Steitz, T.A. 登録日 2014-06-03 公開日 2014-09-03 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Structural basis for the fast self-cleavage reaction catalyzed by the twister ribozyme. Proc.Natl.Acad.Sci.USA, 111, 2014
3RAX	Dpo4 extension ternary complex with 3'-terminal primer T base opposite the 1-methylguanine (M1G) lesion 分子名称: 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(*CP*CP*TP*AP*AP*CP*(MG1)P*CP*TP*AP*CP*CP*AP*TP*CP*CP*AP*AP*CP*C)-3'), ... 著者 Rechkoblit, O, Patel, D.J. 登録日 2011-03-28 公開日 2011-06-15 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.891 Å) 主引用文献 Implications for damage recognition during Dpo4-mediated mutagenic bypass of m1G and m3C lesions. Structure, 19, 2011
8GAO	bacteriophage T4 stalled primosome with mutant gp41-E227Q 分子名称: DNA (70-mer), DNA primase, DnaB-like replicative helicase, ... 著者 Feng, X, Li, H. 登録日 2023-02-23 公開日 2023-06-07 最終更新日 2023-08-23 実験手法 ELECTRON MICROSCOPY (4.1 Å) 主引用文献 Structural basis of the T4 bacteriophage primosome assembly and primer synthesis. Nat Commun, 14, 2023
5OKI	Crystal structure of the Ctf18-1-8 module from Ctf18-RFC in complex with a 63 kDa fragment of DNA Polymerase epsilon 分子名称: Chromosome transmission fidelity protein 18, Chromosome transmission fidelity protein 8, DNA polymerase epsilon catalytic subunit A, ... 著者 Grabarczyk, D.B, Kisker, C. 登録日 2017-07-25 公開日 2017-12-20 最終更新日 2018-01-10 実験手法 X-RAY DIFFRACTION (4.5 Å) 主引用文献 Structural Basis for the Recruitment of Ctf18-RFC to the Replisome. Structure, 26, 2018
8B54	CDK2/cyclin A2 in complex with pyrazolo[4,3-d]pyrimidine inhibitor LGR6768 分子名称: 1,2-ETHANEDIOL, Cyclin-A2, Cyclin-dependent kinase 2, ... 著者 Djukic, S, Skerlova, J, Rezacova, P. 登録日 2022-09-21 公開日 2023-03-29 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Characterization of new highly selective pyrazolo[4,3-d]pyrimidine inhibitor of CDK7. Biomed Pharmacother, 161, 2023
2L2I	NMR Structure of the complex between the Tfb1 subunit of TFIIH and the activation domain of EKLF 分子名称: Krueppel-like factor 1, RNA polymerase II transcription factor B subunit 1 著者 Mas, C, Di Lello, P, Lafrance-Vanasse, J, Omichinski, J.G. 登録日 2010-08-18 公開日 2011-07-06 最終更新日 2024-05-01 実験手法 SOLUTION NMR 主引用文献 NMR Structure of the complex between the Tfb1 subunit of TFIIH and the activation domain of EKLF To be Published
5Y4Z	Crystal structure of the Zika virus NS3 helicase complex with AMPPNP 分子名称: MANGANESE (II) ION, NS3 helicase, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER 著者 Li, L. 登録日 2017-08-06 公開日 2017-08-30 最終更新日 2024-03-27 実験手法 X-RAY DIFFRACTION (1.3 Å) 主引用文献 Structural view of the helicase reveals that Zika virus uses a conserved mechanism for unwinding RNA Acta Crystallogr.,Sect.F, 74, 2018
3NDK	RB69 DNA Polymerase (Y567A) Ternary Complex with dCTP Opposite dG 分子名称: 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(*GP*CP*GP*GP*AP*CP*TP*GP*CP*TP*TP*AP*(DOC))-3'), ... 著者 Wang, M, Wang, J, Konigsberg, W.H. 登録日 2010-06-07 公開日 2011-01-26 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Variation in Mutation Rates Caused by RB69pol Fidelity Mutants Can Be Rationalized on the Basis of Their Kinetic Behavior and Crystal Structures. J.Mol.Biol., 406, 2011
5EFQ	Crystal structure of human Cdk13/Cyclin K in complex with ADP-aluminum fluoride 分子名称: ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, Cyclin-K, ... 著者 Hoenig, D, Greifenberg, A.K, Anand, K, Geyer, M. 登録日 2015-10-24 公開日 2015-12-30 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural and Functional Analysis of the Cdk13/Cyclin K Complex. Cell Rep, 14, 2016
7VQP	Vitamin D receptor complexed with a lithocholic acid derivative 分子名称: 3-((R)-4-((3R,5R,8R,9S,10S,13R,14S,17R)-3-(2-hydroxy-2-methylpropyl)-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanamido)propanoic acid, Mediator of RNA polymerase II transcription subunit 1, Vitamin D3 receptor 著者 Kato, K, Numoto, N, Kagechika, H, Tanatani, A, Ito, N. 登録日 2021-10-20 公開日 2022-03-09 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.94 Å) 主引用文献 Lithocholic Acid Amides as Potent Vitamin D Receptor Agonists. Biomolecules, 12, 2022
4NST	Crystal structure of human Cdk12/Cyclin K in complex with ADP-aluminum fluoride 分子名称: 1,2-ETHANEDIOL, ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, ... 著者 Boesken, C.A, Farnung, L, Anand, K, Geyer, M. 登録日 2013-11-29 公開日 2014-03-26 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 The structure and substrate specificity of human Cdk12/Cyclin K. Nat Commun, 5, 2014
1B8I	STRUCTURE OF THE HOMEOTIC UBX/EXD/DNA TERNARY COMPLEX 分子名称: DNA (5'-D(*AP*CP*GP*TP*GP*AP*TP*TP*TP*AP*TP*GP*GP*CP*G)-3'), DNA (5'-D(*GP*TP*CP*GP*CP*CP*AP*TP*AP*AP*AP*TP*CP*AP*C)-3'), PROTEIN (HOMEOBOX PROTEIN EXTRADENTICLE), ... 著者 Passner, J.M, Ryoo, H.-D, Shen, L, Mann, R.S, Aggarwal, A.K. 登録日 1999-02-01 公開日 1999-04-12 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structure of a DNA-bound Ultrabithorax-Extradenticle homeodomain complex. Nature, 397, 1999
1DRZ	U1A SPLICEOSOMAL PROTEIN/HEPATITIS DELTA VIRUS GENOMIC RIBOZYME COMPLEX 分子名称: MAGNESIUM ION, PROTEIN (U1 SMALL RIBONUCLEOPROTEIN A), RNA (HEPATITIS DELTA VIRUS GENOMIC RIBOZYME), ... 著者 Ferre-D'Amare, A.R, Zhou, K, Doudna, J.A. 登録日 1998-09-01 公開日 1999-02-16 最終更新日 2021-11-03 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Crystal structure of a hepatitis delta virus ribozyme. Nature, 395, 1998
2KIQ	Solution structure of the FF Domain 2 of human transcription elongation factor CA150 分子名称: Transcription elongation regulator 1 著者 Zeng, J, Boyles, J, Tripathy, C, Yan, A, Zhou, P, Donald, B.R. 登録日 2009-05-07 公開日 2009-07-28 最終更新日 2024-05-22 実験手法 SOLUTION NMR 主引用文献 High-resolution protein structure determination starting with a global fold calculated from exact solutions to the RDC equations. J.Biomol.Nmr, 45, 2009
1E8S	Alu domain of the mammalian SRP (potential Alu retroposition intermediate) 分子名称: 7SL RNA, 88-MER, EUROPIUM (III) ION, ... 著者 Weichenrieder, O, Wild, K, Strub, K, Cusack, S. 登録日 2000-09-29 公開日 2000-11-08 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (4 Å) 主引用文献 Structure and Assembly of the Alu Domain of the Mammalian Signal Recognition Particle Nature, 408, 2000
6Q3C	CDK2 in complex with FragLite1 分子名称: 4-bromo-1H-pyrazole, Cyclin-dependent kinase 2 著者 Wood, D.J, Martin, M.P, Noble, M.E.M. 登録日 2018-12-04 公開日 2019-03-20 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.29 Å) 主引用文献 FragLites-Minimal, Halogenated Fragments Displaying Pharmacophore Doublets. An Efficient Approach to Druggability Assessment and Hit Generation. J.Med.Chem., 62, 2019
6Q3B	CDK2 in complex with FragLite2 分子名称: 4-IODOPYRAZOLE, Cyclin-dependent kinase 2 著者 Wood, D.J, Martin, M.P, Noble, M.E.M. 登録日 2018-12-04 公開日 2019-03-20 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.11 Å) 主引用文献 FragLites-Minimal, Halogenated Fragments Displaying Pharmacophore Doublets. An Efficient Approach to Druggability Assessment and Hit Generation. J.Med.Chem., 62, 2019
6Q49	CDK2 in complex with FragLite6 分子名称: 4-bromanyl-1~{H}-pyridin-2-one, Cyclin-dependent kinase 2, DIMETHYL SULFOXIDE 著者 Wood, D.J, Martin, M.P, Noble, M.E.M. 登録日 2018-12-05 公開日 2019-03-20 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1 Å) 主引用文献 FragLites-Minimal, Halogenated Fragments Displaying Pharmacophore Doublets. An Efficient Approach to Druggability Assessment and Hit Generation. J.Med.Chem., 62, 2019
6Q4G	CDK2 in complex with FragLite37 分子名称: 2-[3-(2-azanyl-9~{H}-purin-6-yl)phenyl]ethanoic acid, Cyclin-dependent kinase 2 著者 Wood, D.J, Martin, M.P, Noble, M.E.M. 登録日 2018-12-05 公開日 2019-03-20 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (0.98 Å) 主引用文献 FragLites-Minimal, Halogenated Fragments Displaying Pharmacophore Doublets. An Efficient Approach to Druggability Assessment and Hit Generation. J.Med.Chem., 62, 2019
6Q48	CDK2 in complex with FragLite7 分子名称: 4-iodanyl-3~{H}-pyridin-2-one, Cyclin-dependent kinase 2, DIMETHYL SULFOXIDE 著者 Wood, D.J, Martin, M.P, Noble, M.E.M. 登録日 2018-12-05 公開日 2019-03-20 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.03 Å) 主引用文献 FragLites-Minimal, Halogenated Fragments Displaying Pharmacophore Doublets. An Efficient Approach to Druggability Assessment and Hit Generation. J.Med.Chem., 62, 2019

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