8B54
CDK2/cyclin A2 in complex with pyrazolo[4,3-d]pyrimidine inhibitor LGR6768
Summary for 8B54
Entry DOI | 10.2210/pdb8b54/pdb |
Descriptor | Cyclin-dependent kinase 2, Cyclin-A2, ~{N}-[(2-phenylphenyl)methyl]-5-piperidin-4-ylsulfanyl-3-propan-2-yl-2~{H}-pyrazolo[4,3-d]pyrimidin-7-amine, ... (6 entities in total) |
Functional Keywords | cyclin-dependent kinase 2, cyclin a2, cancer, cell cycle |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 4 |
Total formula weight | 128945.44 |
Authors | Djukic, S.,Skerlova, J.,Rezacova, P. (deposition date: 2022-09-21, release date: 2023-03-29, Last modification date: 2024-02-07) |
Primary citation | Kovalova, M.,Havlicek, L.,Djukic, S.,Skerlova, J.,Perina, M.,Pospisil, T.,Reznickova, E.,Rezacova, P.,Jorda, R.,Krystof, V. Characterization of new highly selective pyrazolo[4,3-d]pyrimidine inhibitor of CDK7. Biomed Pharmacother, 161:114492-114492, 2023 Cited by PubMed: 36931035DOI: 10.1016/j.biopha.2023.114492 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
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