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8B54

CDK2/cyclin A2 in complex with pyrazolo[4,3-d]pyrimidine inhibitor LGR6768

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, C
(A, C)
Cyclin-dependent kinase 2polymer29934143.52UniProt (P24941)
Pfam (PF00069)
Homo sapiens (human)Cell division protein kinase 2,p33 protein kinase
2B, D
(B, D)
Cyclin-A2polymer25829624.32UniProt (P20248)
Pfam (PF00134)
Pfam (PF02984)
Homo sapiens (human)Cyclin-A,Cyclin A
3E, J
(A, C)
~{N}-[(2-phenylphenyl)methyl]-5-piperidin-4-ylsulfanyl-3-propan-2-yl-2~{H}-pyrazolo[4,3-d]pyrimidin-7-aminenon-polymer458.62Chemie (P2V)
4F, H, I, L
(A, B, C, D)
GLYCEROLnon-polymer92.14Chemie (GOL)
5G, K
(A, C)
1,2-ETHANEDIOLnon-polymer62.12Chemie (EDO)
6M, N, O, P
(A, B, C, D)
waterwater18.0314Chemie (HOH)
Sequence modifications
A, C: 1 - 298 (UniProt: P24941)
PDBExternal DatabaseDetails
Ser 0-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains4
Total formula weight127535.7
Non-Polymers*Number of molecules8
Total formula weight1409.8
All*Total formula weight128945.4
*Water molecules are not included.

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PDB entries from 2024-11-06

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