8B54
CDK2/cyclin A2 in complex with pyrazolo[4,3-d]pyrimidine inhibitor LGR6768
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C | Cyclin-dependent kinase 2 | polymer | 299 | 34143.5 | 2 | UniProt (P24941) Pfam (PF00069) In PDB | Homo sapiens (human) | Cell division protein kinase 2,p33 protein kinase |
| 2 | B, D | Cyclin-A2 | polymer | 258 | 29624.3 | 2 | UniProt (P20248) Pfam (PF00134) Pfam (PF02984) In PDB | Homo sapiens (human) | Cyclin-A,Cyclin A |
| 3 | A, C | ~{N}-[(2-phenylphenyl)methyl]-5-piperidin-4-ylsulfanyl-3-propan-2-yl-2~{H}-pyrazolo[4,3-d]pyrimidin-7-amine | non-polymer | 458.6 | 2 | Chemie (P2V) | |||
| 4 | A, B, C, D | GLYCEROL | non-polymer | 92.1 | 4 | Chemie (GOL) | |||
| 5 | A, C | 1,2-ETHANEDIOL | non-polymer | 62.1 | 2 | Chemie (EDO) | |||
| 6 | water | water | 18.0 | 314 | Chemie (HOH) |
Sequence modifications
A, C: 1 - 298 (UniProt: P24941)
| PDB | External Database | Details |
|---|---|---|
| Ser 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 127535.7 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 1409.8 | |
| All* | Total formula weight | 128945.4 |
