3NKB

A 1.9A crystal structure of the HDV ribozyme precleavage suggests both Lewis acid and general acid mechanisms contribute to phosphodiester cleavage

Summary for 3NKB

• Entry DOI: 10.2210/pdb3nkb/pdb
• Related: 1CX0 1SJ3
• Descriptor: DNA/RNA (5'-D(*(DUR))-D(*GP*G)-R(P*CP*UP*UP*GP*CP*A)-3'), The hepatitis delta virus ribozyme, MAGNESIUM ION, ... (4 entities in total)
• Functional Keywords: catalytic rna, metal-mediated catalysis, phosphodiester cleavage, dna, rna
• Total number of polymer chains: 2
• Total formula weight: 23636.17

Authors

Chen, J.-H.,Yajima, R.,Chadalavada, D.M.,Chase, E.,Bevilacqua, P.C.,Golden, B.L. (deposition date: 2010-06-18, release date: 2010-09-01, Last modification date: 2023-09-06)

• Primary citation: Chen, J.H.,Yajima, R.,Chadalavada, D.M.,Chase, E.,Bevilacqua, P.C.,Golden, B.L.; A 1.9 A crystal structure of the HDV ribozyme precleavage suggests both Lewis acid and general acid mechanisms contribute to phosphodiester cleavage.; Biochemistry, 49:6508-6518, 2010; PubMed: 20677830; DOI: 10.1021/bi100670p

Experimental method

X-RAY DIFFRACTION (1.916 Å)