2XAG
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![BU of 2xag by Molmil](/molmil-images/mine/2xag) | Crystal structure of LSD1-CoREST in complex with para-bromo-(-)-trans- 2-phenylcyclopropyl-1-amine | 分子名称: | 3-(4-BROMOPHENYL)PROPANAMIDE, FLAVIN-ADENINE DINUCLEOTIDE, LYSINE-SPECIFIC HISTONE DEMETHYLASE 1, ... | 著者 | Binda, C, Valente, S, Romanenghi, M, Pilotto, S, Cirilli, R, Karytinos, A, Ciossani, G, Botrugno, O.A, Forneris, F, Tardugno, M, Edmondson, D.E, Minucci, S, Mattevi, A, Mai, A. | 登録日 | 2010-03-31 | 公開日 | 2010-05-05 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Biochemical, Structural, and Biological Evaluation of Tranylcypromine Derivatives as Inhibitors of Histone Demethylases Lsd1 and Lsd2. J.Am.Chem.Soc., 132, 2010
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2QD9
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![BU of 2qd9 by Molmil](/molmil-images/mine/2qd9) | P38 Alpha Map Kinase inhibitor based on heterobicyclic scaffolds | 分子名称: | 1-[5-[[3-[2,4-bis(fluoranyl)phenyl]-6,8-dihydro-5~{H}-imidazo[1,5-a]pyrazin-7-yl]carbonyl]-6-methoxy-1~{H}-pyrrolo[2,3-b]pyridin-3-yl]-2-[(3~{R})-3-oxidanylpyrrolidin-1-yl]ethane-1,2-dione, Mitogen-activated protein kinase 14 | 著者 | Sack, J.S. | 登録日 | 2007-06-20 | 公開日 | 2007-08-21 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Synthesis and SAR of p38alpha MAP kinase inhibitors based on heterobicyclic scaffolds. Bioorg.Med.Chem.Lett., 17, 2007
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4H3Q
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![BU of 4h3q by Molmil](/molmil-images/mine/4h3q) | Crystal structure of human ERK2 complexed with a MAPK docking peptide | 分子名称: | Dual specificity mitogen-activated protein kinase kinase 2, Mitogen-activated protein kinase 1, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | 著者 | Gogl, G, Toeroe, I, Remenyi, A. | 登録日 | 2012-09-14 | 公開日 | 2013-02-27 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Protein-peptide complex crystallization: a case study on the ERK2 mitogen-activated protein kinase Acta Crystallogr.,Sect.D, 69, 2013
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2XAF
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![BU of 2xaf by Molmil](/molmil-images/mine/2xaf) | Crystal structure of LSD1-CoREST in complex with para-bromo-(+)-cis-2- phenylcyclopropyl-1-amine | 分子名称: | 3-(4-BROMOPHENYL)PROPANAMIDE, FLAVIN-ADENINE DINUCLEOTIDE, LYSINE-SPECIFIC HISTONE DEMETHYLASE 1, ... | 著者 | Binda, C, Valente, S, Romanenghi, M, Pilotto, S, Cirilli, R, Karytinos, A, Ciossani, G, Botrugno, O.A, Forneris, F, Tardugno, M, Edmondson, D.E, Minucci, S, Mattevi, A, Mai, A. | 登録日 | 2010-03-31 | 公開日 | 2010-05-05 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (3.25 Å) | 主引用文献 | Biochemical, Structural, and Biological Evaluation of Tranylcypromine Derivatives as Inhibitors of Histone Demethylases Lsd1 and Lsd2. J.Am.Chem.Soc., 132, 2010
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2XAQ
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![BU of 2xaq by Molmil](/molmil-images/mine/2xaq) | Crystal structure of LSD1-CoREST in complex with a tranylcypromine derivative (MC2584, 13b) | 分子名称: | 3-{4-[(PHENYLCARBONYL)AMINO]PHENYL}PROPANOIC ACID, FLAVIN-ADENINE DINUCLEOTIDE, LYSINE-SPECIFIC HISTONE DEMETHYLASE 1, ... | 著者 | Binda, C, Valente, S, Romanenghi, M, Pilotto, S, Cirilli, R, Karytinos, A, Ciossani, G, Botrugno, O.A, Forneris, F, Tardugno, M, Edmondson, D.E, Minucci, S, Mattevi, A, Mai, A. | 登録日 | 2010-03-31 | 公開日 | 2010-05-05 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Biochemical, Structural, and Biological Evaluation of Tranylcypromine Derivatives as Inhibitors of Histone Demethylases Lsd1 and Lsd2. J.Am.Chem.Soc., 132, 2010
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4FV7
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![BU of 4fv7 by Molmil](/molmil-images/mine/4fv7) | |
4FUY
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![BU of 4fuy by Molmil](/molmil-images/mine/4fuy) | |
4FV9
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![BU of 4fv9 by Molmil](/molmil-images/mine/4fv9) | Crystal Structure of the ERK2 complexed with E71 | 分子名称: | 1,2-ETHANEDIOL, 3-[4-(2,3-difluorophenyl)-1,2-oxazol-5-yl]-5-(pyridin-4-yl)-1H-pyrrolo[2,3-b]pyridine, Mitogen-activated protein kinase 1, ... | 著者 | Kang, Y.N, Stuckey, J.A, Xie, X. | 登録日 | 2012-06-29 | 公開日 | 2012-08-29 | 最終更新日 | 2014-09-24 | 実験手法 | X-RAY DIFFRACTION (2.11 Å) | 主引用文献 | Crystal Structure of the ERK2 complexed with E71 TO BE PUBLISHED
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4G6N
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![BU of 4g6n by Molmil](/molmil-images/mine/4g6n) | Crystal Structure of the ERK2 | 分子名称: | 3-(4-chlorophenyl)-4,5,6,7-tetrahydro-1H-indazole, Mitogen-activated protein kinase 1, SULFATE ION | 著者 | Kang, Y.N, Stuckey, J.A, Xie, X. | 登録日 | 2012-07-19 | 公開日 | 2012-09-19 | 最終更新日 | 2017-11-15 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Crystal Structure of the ERK2 complexed with EK0 to be published
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4FV4
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![BU of 4fv4 by Molmil](/molmil-images/mine/4fv4) | Crystal Structure of the ERK2 complexed with EK7 | 分子名称: | 9-(dimethylamino)-2-[(3-hydroxyphenyl)amino]-5,6-dihydrothieno[3,4-h]quinazoline-7-carbonitrile, GLYCEROL, Mitogen-activated protein kinase 1, ... | 著者 | Kang, Y.N, Stuckey, J.A, Xie, X. | 登録日 | 2012-06-29 | 公開日 | 2012-08-29 | 最終更新日 | 2014-09-24 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Crystal Structure of the ERK2 complexed with EK7 TO BE PUBLISHED
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4FV1
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2RG5
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![BU of 2rg5 by Molmil](/molmil-images/mine/2rg5) | Phenylalanine pyrrolotriazine p38 alpha map kinase inhibitor compound 11B | 分子名称: | Mitogen-activated protein kinase 14, N-ethyl-4-{[5-(methoxycarbamoyl)-2-methylphenyl]amino}-5-methylpyrrolo[2,1-f][1,2,4]triazine-6-carboxamide | 著者 | Sack, J.S. | 登録日 | 2007-10-02 | 公開日 | 2008-01-15 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Design, Synthesis, and Anti-inflammatory Properties of Orally Active 4-(Phenylamino)-pyrrolo[2,1-f][1,2,4]triazine p38alpha Mitogen-Activated Protein Kinase Inhibitors J.Med.Chem., 51, 2008
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2XAS
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![BU of 2xas by Molmil](/molmil-images/mine/2xas) | Crystal structure of LSD1-CoREST in complex with a tranylcypromine derivative (MC2580, 14e) | 分子名称: | 3-[4-({N-[(BENZYLOXY)CARBONYL]-L-PHENYLALANYL}AMINO)PHENYL]PROPANOIC ACID, FLAVIN-ADENINE DINUCLEOTIDE, LYSINE-SPECIFIC HISTONE DEMETHYLASE 1, ... | 著者 | Binda, C, Valente, S, Romanenghi, M, Pilotto, S, Cirilli, R, Karytinos, A, Ciossani, G, Botrugno, O.A, Forneris, F, Tardugno, M, Edmondson, D.E, Minucci, S, Mattevi, A, Mai, A. | 登録日 | 2010-03-31 | 公開日 | 2010-05-05 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Biochemical, Structural, and Biological Evaluation of Tranylcypromine Derivatives as Inhibitors of Histone Demethylases Lsd1 and Lsd2. J.Am.Chem.Soc., 132, 2010
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2XAH
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![BU of 2xah by Molmil](/molmil-images/mine/2xah) | Crystal structure of LSD1-CoREST in complex with (+)-trans-2- phenylcyclopropyl-1-amine | 分子名称: | 3-PHENYLPROPANAL, FLAVIN-ADENINE DINUCLEOTIDE, LYSINE-SPECIFIC HISTONE DEMETHYLASE 1, ... | 著者 | Binda, C, Valente, S, Romanenghi, M, Pilotto, S, Cirilli, R, Karytinos, A, Ciossani, G, Botrugno, O.A, Forneris, F, Tardugno, M, Edmondson, D.E, Minucci, S, Mattevi, A, Mai, A. | 登録日 | 2010-03-31 | 公開日 | 2010-05-05 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Biochemical, Structural, and Biological Evaluation of Tranylcypromine Derivatives as Inhibitors of Histone Demethylases Lsd1 and Lsd2. J.Am.Chem.Soc., 132, 2010
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3FKN
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![BU of 3fkn by Molmil](/molmil-images/mine/3fkn) | P38 kinase crystal structure in complex with RO7125 | 分子名称: | 3-[2-chloro-5-(methylsulfonyl)phenyl]-6-(2,4-difluorophenoxy)-1H-pyrazolo[3,4-d]pyrimidine, Mitogen-activated protein kinase 14 | 著者 | Kuglstatter, A, Ghate, M. | 登録日 | 2008-12-17 | 公開日 | 2009-12-22 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Mapping Binding Pocket Volume: Potential Applications towards Ligand Design and Selectivity To be Published
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3FMH
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![BU of 3fmh by Molmil](/molmil-images/mine/3fmh) | |
3FMM
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![BU of 3fmm by Molmil](/molmil-images/mine/3fmm) | |
2GTM
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![BU of 2gtm by Molmil](/molmil-images/mine/2gtm) | Mutated Mouse P38 MAP Kinase Domain in complex with Inhibitor PG-892579 | 分子名称: | 8-(2-CHLOROPHENYLAMINO)-2-(2,6-DIFLUOROPHENYLAMINO)-9-ETHYL-9H-PURINE-1,7-DIIUM, Mitogen-activated protein kinase 14 | 著者 | Walter, R.L, Mekel, M.J, Evdokimov, A.G, Pokross, M.E, Sabat, M. | 登録日 | 2006-04-28 | 公開日 | 2006-05-23 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | The development of novel C-2, C-8, and N-9 trisubstituted purines as inhibitors of TNF-alpha production. Bioorg.Med.Chem.Lett., 16, 2006
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8PP6
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![BU of 8pp6 by Molmil](/molmil-images/mine/8pp6) | human RYBP-PRC1 bound to H2AK118ub1 nucleosome | 分子名称: | DNA (215-MER), Histone H2A, Histone H2B, ... | 著者 | Ciapponi, M, Benda, C, Mueller, J. | 登録日 | 2023-07-06 | 公開日 | 2024-04-03 | 最終更新日 | 2024-07-31 | 実験手法 | ELECTRON MICROSCOPY (3.18 Å) | 主引用文献 | Structural basis of the histone ubiquitination read-write mechanism of RYBP-PRC1. Nat.Struct.Mol.Biol., 31, 2024
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4AJY
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![BU of 4ajy by Molmil](/molmil-images/mine/4ajy) | von Hippel-Lindau protein-ElonginB-ElonginC complex, bound to Hif1- alpha peptide | 分子名称: | GLYCEROL, HYPOXIA-INDUCIBLE FACTOR 1-ALPHA, TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 1, ... | 著者 | Van Molle, I, Thomann, A, Buckley, D.L, So, E.C, Lang, S, Crews, C.M, Ciulli, A. | 登録日 | 2012-02-21 | 公開日 | 2012-11-14 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.73 Å) | 主引用文献 | Dissecting Fragment-Based Lead Discovery at the Von Hippel-Lindau Protein:Hypoxia Inducible Factor 1Alpha Protein-Protein Interface. Chem.Biol., 19, 2012
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6GYU
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![BU of 6gyu by Molmil](/molmil-images/mine/6gyu) | Cryo-EM structure of the CBF3-msk complex of the budding yeast kinetochore | 分子名称: | Centromere DNA-binding protein complex CBF3 subunit A, Centromere DNA-binding protein complex CBF3 subunit B, Centromere DNA-binding protein complex CBF3 subunit C, ... | 著者 | Yan, K, Zhang, Z, Yang, J, McLaughlin, S.H, Barford, D. | 登録日 | 2018-07-02 | 公開日 | 2018-12-05 | 最終更新日 | 2019-12-18 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Architecture of the CBF3-centromere complex of the budding yeast kinetochore. Nat. Struct. Mol. Biol., 25, 2018
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3FL4
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![BU of 3fl4 by Molmil](/molmil-images/mine/3fl4) | P38 kinase crystal structure in complex with RO5634 | 分子名称: | 6-(2,4-difluorophenoxy)-3-(2-methylphenyl)-1H-pyrazolo[3,4-d]pyrimidine, Mitogen-activated protein kinase 14 | 著者 | Kuglstatter, A, Knapp, M. | 登録日 | 2008-12-18 | 公開日 | 2009-12-22 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Mapping Binding Pocket Volume: Potential Applications towards Ligand Design and Selectivity To be Published
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3FML
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![BU of 3fml by Molmil](/molmil-images/mine/3fml) | |
3FLZ
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![BU of 3flz by Molmil](/molmil-images/mine/3flz) | |
8BYA
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![BU of 8bya by Molmil](/molmil-images/mine/8bya) | Cryo-EM structure of SKP1-SKP2-CKS1-CDK2-CyclinA-p27KIP1 Complex | 分子名称: | Cyclin-A2, Cyclin-dependent kinase 2, Cyclin-dependent kinase inhibitor 1B, ... | 著者 | Rowland, R.J, Salamina, M, Endicott, J.A, Noble, M.E. | 登録日 | 2022-12-12 | 公開日 | 2023-06-28 | 最終更新日 | 2023-07-19 | 実験手法 | ELECTRON MICROSCOPY (3.38 Å) | 主引用文献 | Cryo-EM structure of SKP1-SKP2-CKS1 in complex with CDK2-cyclin A-p27KIP1. Sci Rep, 13, 2023
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