7DTC
| voltage-gated sodium channel Nav1.5-E1784K | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Sodium channel protein type 5 subunit alpha | 著者 | Yan, N, Pan, X, Li, Z. | 登録日 | 2021-01-04 | 公開日 | 2021-03-24 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Structure of human Na v 1.5 reveals the fast inactivation-related segments as a mutational hotspot for the long QT syndrome. Proc.Natl.Acad.Sci.USA, 118, 2021
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7XUF
| Cryo-EM structure of the AKT1-AtKC1 complex from Arabidopsis thaliana | 分子名称: | POTASSIUM ION, Potassium channel AKT1, Potassium channel KAT3 | 著者 | Yang, G.H, Lu, Y.M, Jia, Y.T, Yang, F, Zhang, Y.M, Xu, X, Li, X.M, Lei, J.L. | 登録日 | 2022-05-18 | 公開日 | 2022-11-09 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Structural basis for the activity regulation of a potassium channel AKT1 from Arabidopsis. Nat Commun, 13, 2022
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7FHK
| Structure of AtTPC1 with 1 mM Ca2+ | 分子名称: | AtTPC1-Cter, CALCIUM ION, Two pore calcium channel protein 1,GFP | 著者 | Ye, F, Xu, L, Li, X, Jiang, Y, Guo, J. | 登録日 | 2021-07-29 | 公開日 | 2021-12-01 | 最終更新日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Voltage-gating and cytosolic Ca 2+ activation mechanisms of Arabidopsis two-pore channel AtTPC1. Proc.Natl.Acad.Sci.USA, 118, 2021
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7FHN
| Structure of AtTPC1 D240A/D454A/E528A mutant with 1 mM Ca2+ | 分子名称: | CALCIUM ION, Two pore calcium channel protein 1,GFP | 著者 | Ye, F, Xu, L, Li, X, Jiang, Y, Guo, J. | 登録日 | 2021-07-29 | 公開日 | 2021-12-01 | 最終更新日 | 2022-03-16 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Voltage-gating and cytosolic Ca 2+ activation mechanisms of Arabidopsis two-pore channel AtTPC1. Proc.Natl.Acad.Sci.USA, 118, 2021
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6DRJ
| Structure of TRPM2 ion channel receptor by single particle electron cryo-microscopy, ADPR/Ca2+ bound state | 分子名称: | ADENOSINE-5-DIPHOSPHORIBOSE, CALCIUM ION, Transient receptor potential cation channel, ... | 著者 | Du, J, Lu, W, Huang, Y, Winkler, P, Sun, W. | 登録日 | 2018-06-12 | 公開日 | 2018-09-19 | 最終更新日 | 2018-10-10 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Architecture of the TRPM2 channel and its activation mechanism by ADP-ribose and calcium. Nature, 562, 2018
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7W77
| cryo-EM structure of human NaV1.3/beta1/beta2-bulleyaconitineA | 分子名称: | (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Jiang, D, Li, X. | 登録日 | 2021-12-03 | 公開日 | 2022-04-06 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Structural basis for modulation of human Na V 1.3 by clinical drug and selective antagonist. Nat Commun, 13, 2022
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5WIE
| Crystal structure of a Kv1.2-2.1 chimera K+ channel V406W mutant in an inactivated state | 分子名称: | (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, POTASSIUM ION, ... | 著者 | Pau, V, Zhou, Y, Ramu, Y, Xu, Y, Lu, Z. | 登録日 | 2017-07-19 | 公開日 | 2017-08-30 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | 主引用文献 | Crystal structure of an inactivated mutant mammalian voltage-gated K(+) channel. Nat. Struct. Mol. Biol., 24, 2017
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7L2R
| Cryo-EM structure of DkTx-bound minimal TRPV1 at the pre-open state | 分子名称: | (2S)-1-(butanoyloxy)-3-{[(R)-hydroxy{[(1r,2R,3S,4S,5R,6S)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propan-2-yl tridecanoate, (9R,12R)-15-amino-12-hydroxy-6,12-dioxo-7,11,13-trioxa-12lambda~5~-phosphapentadecan-9-yl undecanoate, SODIUM ION, ... | 著者 | Zhang, K, Julius, D, Cheng, Y. | 登録日 | 2020-12-17 | 公開日 | 2021-09-22 | 最終更新日 | 2021-10-13 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Structural snapshots of TRPV1 reveal mechanism of polymodal functionality. Cell, 184, 2021
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5E1J
| Structure of voltage-gated two-pore channel TPC1 from Arabidopsis thaliana | 分子名称: | BARIUM ION, CALCIUM ION, Two pore calcium channel protein 1 | 著者 | Guo, J, Zeng, W, Chen, Q, Lee, C, Chen, L, Yang, Y, Jiang, Y. | 登録日 | 2015-09-29 | 公開日 | 2015-12-16 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (3.308 Å) | 主引用文献 | Structure of the voltage-gated two-pore channel TPC1 from Arabidopsis thaliana. Nature, 531, 2016
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4P30
| Structure of NavMS mutant in presence of PI1 compound | 分子名称: | DODECAETHYLENE GLYCOL, HEGA-10, Ion transport protein, ... | 著者 | Bagneris, C, Naylor, C.E, Wallace, B.A. | 登録日 | 2014-03-05 | 公開日 | 2014-06-04 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (3.31 Å) | 主引用文献 | Prokaryotic NavMs channel as a structural and functional model for eukaryotic sodium channel antagonism. Proc.Natl.Acad.Sci.USA, 111, 2014
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7RHI
| Cryo-EM structure of human rod CNGA1/B1 channel in cGMP-bound openII state | 分子名称: | CYCLIC GUANOSINE MONOPHOSPHATE, Cyclic nucleotide-gated cation channel beta-1, cGMP-gated cation channel alpha-1 | 著者 | Xue, J, Han, Y, Jiang, Y. | 登録日 | 2021-07-17 | 公開日 | 2021-11-03 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (3.31 Å) | 主引用文献 | Structural mechanisms of assembly, permeation, gating, and pharmacology of native human rod CNG channel. Neuron, 110, 2022
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7RHH
| Cryo-EM structure of human rod CNGA1/B1 channel in cGMP-bound openI state | 分子名称: | CYCLIC GUANOSINE MONOPHOSPHATE, Cyclic nucleotide-gated cation channel beta-1, cGMP-gated cation channel alpha-1 | 著者 | Xue, J, Han, Y, Jiang, Y. | 登録日 | 2021-07-17 | 公開日 | 2021-11-03 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (3.31 Å) | 主引用文献 | Structural mechanisms of assembly, permeation, gating, and pharmacology of native human rod CNG channel. Neuron, 110, 2022
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5WO6
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7SIT
| Crystal structure of Voltage gated potassium ion channel, Kv 1.2 chimera-3m | 分子名称: | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, OXYGEN ATOM, POTASSIUM ION, ... | 著者 | Reddi, R, Matulef, K, Riederer, E.A, Whorton, M.R, Valiyaveetil, F.I. | 登録日 | 2021-10-14 | 公開日 | 2022-05-04 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (3.32 Å) | 主引用文献 | Structural basis for C-type inactivation in a Shaker family voltage-gated K + channel. Sci Adv, 8, 2022
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8SDA
| CryoEM structure of rat Kv2.1(1-598) L403A mutant in nanodiscs | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, POTASSIUM ION, Potassium voltage-gated channel subfamily B member 1 | 著者 | Tan, X, Swartz, K.J. | 登録日 | 2023-04-06 | 公開日 | 2023-09-27 | 最終更新日 | 2023-10-25 | 実験手法 | ELECTRON MICROSCOPY (3.32 Å) | 主引用文献 | Inactivation of the Kv2.1 channel through electromechanical coupling. Nature, 622, 2023
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8E4L
| The open state mouse TRPM8 structure in complex with the cooling agonist C3, AITC, and PI(4,5)P2 | 分子名称: | 3-isothiocyanatoprop-1-ene, CALCIUM ION, Transient receptor potential cation channel subfamily M member 8, ... | 著者 | Yin, Y, Zhang, F, Feng, S, Butay, K.J, Borgnia, M.J, Im, W, Lee, S.-Y. | 登録日 | 2022-08-18 | 公開日 | 2022-10-26 | 実験手法 | ELECTRON MICROSCOPY (3.32 Å) | 主引用文献 | Activation mechanism of the mouse cold-sensing TRPM8 channel by cooling agonist and PIP 2. Science, 378, 2022
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7RQZ
| Cryo-EM structure of the full-length TRPV1 with RTx at 48 degrees Celsius, in an open state, class alpha | 分子名称: | 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, Transient receptor potential cation channel subfamily V member 1, [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate, ... | 著者 | Kwon, D.H, Suo, Y, Lee, S.-Y. | 登録日 | 2021-08-08 | 公開日 | 2022-06-01 | 実験手法 | ELECTRON MICROSCOPY (3.32 Å) | 主引用文献 | Vanilloid-dependent TRPV1 opening trajectory from cryoEM ensemble analysis. Nat Commun, 13, 2022
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8SLY
| Rat TRPV2 bound with 2 CBD ligands in nanodiscs | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, SODIUM ION, Transient receptor potential cation channel subfamily V member 2, ... | 著者 | Tan, X, Swartz, K.J. | 登録日 | 2023-04-24 | 公開日 | 2023-05-31 | 最終更新日 | 2023-07-05 | 実験手法 | ELECTRON MICROSCOPY (3.32 Å) | 主引用文献 | Cannabidiol sensitizes TRPV2 channels to activation by 2-APB. Elife, 12, 2023
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6DQN
| Class 1 IP3-bound human type 3 1,4,5-inositol trisphosphate receptor | 分子名称: | D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE, Inositol 1,4,5-trisphosphate receptor type 3, ZINC ION | 著者 | Hite, R.K, Paknejad, N. | 登録日 | 2018-06-11 | 公開日 | 2018-08-01 | 最終更新日 | 2019-11-20 | 実験手法 | ELECTRON MICROSCOPY (3.33 Å) | 主引用文献 | Structural basis for the regulation of inositol trisphosphate receptors by Ca2+and IP3. Nat. Struct. Mol. Biol., 25, 2018
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8EVA
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8EV9
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8EVC
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5IWO
| Bacterial sodium channel pore domain, low bromide | 分子名称: | BROMIDE ION, Ion transport protein | 著者 | Shaya, D, Findeisen, F, Rohaim, A, Minor, D.L. | 登録日 | 2016-03-22 | 公開日 | 2016-03-30 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (3.33 Å) | 主引用文献 | Unfolding of a Temperature-Sensitive Domain Controls Voltage-Gated Channel Activation. Cell, 164, 2016
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7MZ7
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8T1D
| Open-state cryo-EM structure of full-length human TRPV4 in complex with agonist 4a-PDD | 分子名称: | (1aR,1bS,4aS,7aS,7bS,8R,9R,9aS)-9a-(decanoyloxy)-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-1H-cyclopropa[3,4]benzo[1,2-e]azulen-9-yl decanoate, Transient receptor potential cation channel subfamily V member 4/Enhanced green fluorescent protein chimera | 著者 | Talyzina, I.A, Nadezhdin, K.D, Neuberger, A, Sobolevsky, A.I. | 登録日 | 2023-06-02 | 公開日 | 2023-07-05 | 実験手法 | ELECTRON MICROSCOPY (3.35 Å) | 主引用文献 | Structure of human TRPV4 in complex with GTPase RhoA. Nat Commun, 14, 2023
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