7W77

cryo-EM structure of human NaV1.3/beta1/beta2-bulleyaconitineA

Summary for 7W77

• Entry DOI: 10.2210/pdb7w77/pdb
• EMDB information: 32341
• Descriptor: Sodium channel subunit beta-1, Sodium channel subunit beta-2, Sodium channel protein type 3 subunit alpha, ... (9 entities in total)
• Functional Keywords: ion channel, drug, antagonist, membrane protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 285991.70

Authors

Jiang, D.,Li, X. (deposition date: 2021-12-03, release date: 2022-04-06)

• Primary citation: Li, X.,Xu, F.,Xu, H.,Zhang, S.,Gao, Y.,Zhang, H.,Dong, Y.,Zheng, Y.,Yang, B.,Sun, J.,Zhang, X.C.,Zhao, Y.,Jiang, D.; Structural basis for modulation of human Na V 1.3 by clinical drug and selective antagonist.; Nat Commun, 13:1286-1286, 2022; PubMed: 35277491; DOI: 10.1038/s41467-022-28808-5

Experimental method

ELECTRON MICROSCOPY (3.3 Å)