7W77

cryo-EM structure of human NaV1.3/beta1/beta2-bulleyaconitineA

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (B)	Sodium channel subunit beta-1	polymer	218	24732.1	1	UniProt (Q07699) Pfam (PF07686)	Homo sapiens (human)
2	B (C)	Sodium channel subunit beta-2	polymer	215	24355.9	1	UniProt (O60939) Pfam (PF07686)	Homo sapiens (human)	Nav1.7 beta2 subunit
3	C (D)	Sodium channel protein type 3 subunit alpha	polymer	1951	221036.6	1	UniProt (Q9NY46) Pfam (PF00520) Pfam (PF11933) Pfam (PF06512)	Homo sapiens (human)	Sodium channel protein brain III subunit alpha,Sodium channel protein type III subunit alpha,Voltage-gated sodium channel subtype III,Voltage-gated sodium channel subunit alpha Nav1.3
4	D (E)	beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		586.5	1	In PDB GlyTouCan (G15407YE)
5	E (F)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	1	In PDB GlyTouCan (G42666HT)
6	F, G, H, I, J (B, D)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	5	Chemie (NAG)
7	K, L, V (D)	(3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en	non-polymer		544.8	3	Chemie (9Z9)
8	AA, BA, CA, M, N... (D)	[(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate	non-polymer		718.0	16	Chemie (6OU)
9	DA (D)	[(1S,2R,3R,4R,5R,6S,8R,9S,13S,16S,17R,18R)-11-ethyl-5-hydroxy-6,16,18-trimethoxy-4-(4-methoxybenzoyl)-13-(methoxymethyl)-11-azahexacyclo[7.7.2.12,5.01,10.03,8.013,17]nonadecan-8-yl] acetate	non-polymer		627.8	1	Chemie (966)

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	270124.6
Branched	Number of molecules	2
	Total formula weight	1010.9
Non-Polymers*	Number of molecules	25
	Total formula weight	14856.2
All*	Total formula weight	285991.7

*Water molecules are not included.